DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and AT4G19520

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_193687.3	Gene:	AT4G19520 / 827694	AraportID:	AT4G19520	Length:	1744	Species:	Arabidopsis thaliana

Alignment Length:	1210	Identity:	241/1210 - (19%)
Similarity:	397/1210 - (32%)	Gaps:	440/1210 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 QTSP--QKLSLKGSQLGGSILIGNYNYLTQLEVCENEMEVLDLSSLAQLETLKCSRNKLMELIIN 107
            |.||  :|:.||     |.:.:.::....||:    .:.::|||:..::::.......:.:|.:.
plant   623 QYSPNIEKIDLK-----GCLELQSFPDTGQLQ----HLRIVDLSTCKKIKSFPKVPPSIRKLHLQ 678

  Fly   108 GTNLQTLVA-DHN--------YLHNISTTNTHPVPLKLQRIDISHNNFSELPNWV---------- 153
            ||.::.|.: :|:        .|.|:|::|.......|:..|.||  ...||:.|
plant   679 GTGIRDLSSLNHSSESQRLTRKLENVSSSNQDHRKQVLKLKDSSH--LGSLPDIVIFESLEVLDF 741

  Fly   154 GACASLTAINA---SHNRLNNVAVLLRN------YRITELVSLDLAYNDLKQLDQFPEGFSSIRS 209
            ..|:.|..|..   :..||......::.      :.|::||.||:  .:.::|...|.|.|:::.
plant   742 SGCSELEDIQGFPQNLKRLYLAKTAIKEVPSSLCHHISKLVKLDM--ENCERLRDLPMGMSNMKY 804

  Fly   210 LQLQ-----SN-----ELP-SLPDNFFAVTHAR------LETLN-------VSCNKLSTLPRYEQ 250
            |.:.     ||     ||| :|.:.:.|.|..:      ||||:       .:|.||..||. ..
plant   805 LAVLKLSGCSNLENIKELPRNLKELYLAGTAVKEFPSTLLETLSEVVLLDLENCKKLQGLPT-GM 868

  Fly   251 NNHAALVNLSLAG-NHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSG-NM 313
            :....||.|.|:| :.|...:..||:    |..|:||...|..||.: :.:...|:.|.|.. |.
plant   869 SKLEFLVMLKLSGCSKLEIIVDLPLN----LIELYLAGTAIRELPPS-IGDLALLDTLDLKNCNR 928

  Fly   314 LQQLPEEVATLGQLRVLRC--CNNLLLCTPQLAK------------------------------- 345
            |:.||.|:..|..|:||..  |:.|.:.|..|.|
plant   929 LRHLPMEMHNLNPLKVLDLSNCSELEVFTSSLPKVRELRPAPTVMLLRSKLPFCFFIFYEHRVTL 993

  Fly   346 ----------------LAMLKVLDLSHNHLDRV--------NLLAL----------VPS--RNLK 374
                            :..||.||||.|....|        .||:|          :|.  |:|:
plant   994 SLYKARLQYIPEEIRWMPSLKTLDLSRNGFTEVPVSIKDFSKLLSLRLRYCENLRSLPQLPRSLQ 1058

  Fly   375 YLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSA------------QR 427
            .|:..|...||:....||    |..|:::.     :|...||:..:.:|.|            |.
plant  1059 LLNAHGCSSLQLITPDFK----QLPRYYTF-----SNCFGLPSHMVSEVLANAPAIVECRKPQQG 1114

  Fly   428 NQNKTS-------------------GPWTM------------GFA------------ETPGSG-- 447
            .:|..:                   |..||            |||            :|.|.|
plant  1115 LENALACSFCLPSPTSRDSKLYLQPGSSTMIILNPKTRSTLVGFAILVEVSFSKDFHDTAGLGFR 1179

  Fly   448 -DCR----------KLSVYQLRAANYGG------SDEALYGMFE-------ALEGRGRAAQEMSH 488
             .||          :.:::...|.   |      :|:.::..|:       ..||      ::..
plant  1180 CVCRWNDKKGHAHKRDNIFHCWAP---GEVVPKINDDHMFVFFDLKMHPSILFEG------DVFG 1235

  Fly   489 LVPDLM--------KQEQMVKDS---------AVRDYMKFTLLAA--------QQQCGSV----- 523
            ::.||:        |||..|.||         .:.|       ||        ..||.|:
plant  1236 ILADLVVFEIFPVNKQEMHVGDSCTITKCGVYVIND-------AAGSSSGNTMTPQCSSMDSLKL 1293

  Fly   524 ------------------RSAALF-----HLTRTRAPSKVRPLKSKRYVLRMASTGGLDAYLIRR 565
                              |..|||     .|...:|....:.|.|..:|:..........|||..
plant  1294 LDGKGKKRLRVNYAGLKQREKALFLYIACLLGGEKADLLAQFLASTDFVIESTLEDLAGRYLIDI 1358

  Fly   566 TSQLRLTKPDV---IQKDQIHSMPDPHVLELIL--------SNDDEYLVVGNAQLWSVMDIDRAA 619
            :|...:..|.:   ..::.||.:| ....||:.        .|:|.:             :....
plant  1359 SSNGEVMMPPLQRNFSREIIHMLP-ASTKELVSMASGSPCNRNNDVF-------------VSFHG 1409

  Fly   620 REIRKEENSLLAAKRLV---------------DIAQSFAAAESLSVIVVRFRHLGT--------D 661
            ::.||:..|.. .|:||               .:........|::|:|....:..:        :
plant  1410 KDFRKQFISDF-LKKLVYKGIRICIGDKILSRSLINKVIKESSIAVVVFSENYASSSLCLLQLME 1473

  Fly   662 VDHLIRELKQSVRK---KPQPVSLPLSSG-------SVCKRTCCDRSNACRHRAIEQEPLAGRSS 716
            :.....||.|.|..   |..|..:...||       ..||:|..|..........:...:||..|
plant  1474 IMKCWEELGQVVMPIFYKVNPSDIRNQSGHFGKGFKKTCKKTINDERQRWSRALTDAASIAGECS 1538

  Fly   717 PSGQSDRDLLAKDKDDEFVLAHARVLQEEQQLEMLDETESVSESVLSEEQFKCWEYMLEQNTQLL 781
            .:..||.|::.|..:|    ...:::..::..:.:...:...::....|..||    :|:..||.
plant  1539 LNWASDADMIEKVAND----IRKKLISSKKLGKQIQRVDCDHDNPWETEFNKC----IERFFQLP 1595

  Fly   782 FD----------------------KELNTISKSFTKQRTVP----NAIMAATVL----PERNDFT 816
            :|                      ||:..|:|...|...|.    |.|....:|    .||:.|.
plant  1596 YDGNHDESLVSLTTEKVIDMKQTLKEIYQITKVKLKNNLVGRRHINNICFMHILYEKCEERSSFN 1660

  Fly   817 SNLMRTVTNKFISTSTPQLPQPITTSVPLGSYHQVK-------QAPPGHFGSALSFQQAHSYGYN 874
            ...:.|:.:               ..:|...|.:.|       :||.|  |....|....:.|..
plant  1661 PTSLHTLYD---------------NGIPYQVYTKRKKHMSGEEKAPIG--GCVGCFYMGQNQGIT 1708

  Fly   875 LFDAKPRPKFHGGTVKRSAGP-----NSAYFGSLQRLMPY 909
                    |..||....:|.|     |..|....|   ||
plant  1709 --------KAGGGRTMPTAYPAAPQANQGYNAGAQ---PY 1737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	2/18 (11%)
		LRR_8	109..169	CDD:290566	17/81 (21%)
		leucine-rich repeat	111..135	CDD:275380	6/32 (19%)
		leucine-rich repeat	136..158	CDD:275380	8/31 (26%)
		leucine-rich repeat	159..183	CDD:275380	5/32 (16%)
		leucine-rich repeat	184..209	CDD:275380	8/24 (33%)
		LRR_8	205..266	CDD:290566	24/85 (28%)
		leucine-rich repeat	210..230	CDD:275380	9/30 (30%)
		leucine-rich repeat	232..255	CDD:275380	9/29 (31%)
		LRR_RI	<256..410	CDD:238064	54/224 (24%)
		leucine-rich repeat	256..276	CDD:275380	8/20 (40%)
		LRR_8	279..359	CDD:290566	31/129 (24%)
		leucine-rich repeat	280..303	CDD:275380	7/22 (32%)
		leucine-rich repeat	304..348	CDD:275380	17/93 (18%)
		leucine-rich repeat	349..372	CDD:275380	12/42 (29%)
		PP2Cc	461..655	CDD:294085	49/285 (17%)
AT4G19520	NP_193687.3	LRR_3	6..>885	CDD:332712	65/275 (24%)
		leucine-rich repeat	602..627	CDD:275381	2/3 (67%)
		leucine-rich repeat	651..671	CDD:275380	3/19 (16%)
		leucine-rich repeat	672..699	CDD:275380	5/26 (19%)
		leucine-rich repeat	701..756	CDD:275380	14/56 (25%)
		LRR	748..>1062	CDD:227223	77/321 (24%)
		leucine-rich repeat	757..780	CDD:275380	3/22 (14%)
		leucine-rich repeat	781..804	CDD:275380	8/24 (33%)
		leucine-rich repeat	826..849	CDD:275380	7/22 (32%)
		leucine-rich repeat	850..894	CDD:275380	12/44 (27%)
		leucine-rich repeat	895..934	CDD:275380	13/39 (33%)
		leucine-rich repeat	942..965	CDD:275380	8/22 (36%)
		leucine-rich repeat	966..1012	CDD:275380	0/45 (0%)
		leucine-rich repeat	1013..1035	CDD:275380	8/21 (38%)
		leucine-rich repeat	1036..1060	CDD:275380	6/23 (26%)
		LRR_3	<1294..>1380	CDD:332712	15/85 (18%)
		LRR_3	1391..>1562	CDD:332712	31/188 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000