DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and AT4G19500

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_193685.6	Gene:	AT4G19500 / 827691	AraportID:	AT4G19500	Length:	1309	Species:	Arabidopsis thaliana

Alignment Length:	260	Identity:	68/260 - (26%)
Similarity:	110/260 - (42%)	Gaps:	60/260 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 CENEMEVLDLSSLAQLETLK--CSR--NKLMELIINGTNLQTLVADHNYLHNISTTNTHPV---- 132
            ||....|  ...:..|..||  ||.  |:....:.:|  |.||..:.:.||    ...:|:
plant  1083 CELSPTV--FGKMYNLRLLKFYCSTSGNQCKLTLPHG--LDTLPDELSLLH----WENYPLVYLP 1139

  Fly   133 ----PLKLQRIDISHNNFSELPNWVGA--CASLTAINASHNRLNNVAVLLRNYRITELVSLDLAY 191
                |:.|..:::.::|..:|  |.|.  ...|..|..||:|           .:|:::.|..|.
plant  1140 QKFNPVNLVELNMPYSNMEKL--WEGKKNLEKLKNIKLSHSR-----------ELTDILMLSEAL 1191

  Fly   192 NDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNV-SCNKLSTLPRYEQNNHAA 255
            | |:.:|.  ||.:|:..:.:      |:|      ...:|.:||: .|::|.:||.........
plant  1192 N-LEHIDL--EGCTSLIDVSM------SIP------CCGKLVSLNMKDCSRLRSLPSMVDLTTLK 1241

  Fly   256 LVNLSLAGNHLNDSIFEPLHN-AAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSG-NMLQQLP 318
            |:|||      ..|.||.:.: |..|..::||...|..||.: :||..||..|.|.. ..||::|
plant  1242 LLNLS------GCSEFEDIQDFAPNLEEIYLAGTSIRELPLS-IRNLTELVTLDLENCERLQEMP 1299

Fly 319 318
plant 1300 1299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	7/22 (32%)
		LRR_8	109..169	CDD:290566	16/69 (23%)
		leucine-rich repeat	111..135	CDD:275380	7/31 (23%)
		leucine-rich repeat	136..158	CDD:275380	5/23 (22%)
		leucine-rich repeat	159..183	CDD:275380	5/23 (22%)
		leucine-rich repeat	184..209	CDD:275380	8/24 (33%)
		LRR_8	205..266	CDD:290566	14/61 (23%)
		leucine-rich repeat	210..230	CDD:275380	2/19 (11%)
		leucine-rich repeat	232..255	CDD:275380	7/23 (30%)
		LRR_RI	<256..410	CDD:238064	23/65 (35%)
		leucine-rich repeat	256..276	CDD:275380	7/19 (37%)
		LRR_8	279..359	CDD:290566	15/41 (37%)
		leucine-rich repeat	280..303	CDD:275380	8/22 (36%)
		leucine-rich repeat	304..348	CDD:275380	6/16 (38%)
		leucine-rich repeat	349..372	CDD:275380
		PP2Cc	461..655	CDD:294085
AT4G19500	NP_193685.6	LRR_3	1..>414	CDD:332712
		DUF640	496..571	CDD:309816
		LRR_3	581..>1291	CDD:332712	65/250 (26%)
		leucine-rich repeat	1147..1169	CDD:275381	5/23 (22%)
		leucine-rich repeat	1170..1192	CDD:275381	8/32 (25%)
		leucine-rich repeat	1193..1216	CDD:275381	7/36 (19%)
		leucine-rich repeat	1261..1283	CDD:275381	8/22 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000