DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and RPP4

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_193420.2	Gene:	RPP4 / 827395	AraportID:	AT4G16860	Length:	1147	Species:	Arabidopsis thaliana

Alignment Length:	412	Identity:	103/412 - (25%)
Similarity:	152/412 - (36%)	Gaps:	119/412 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 SLKGSQLGGSILIGNYNYLTQLEVCENEMEVLDLSSLAQLETLKCS-RN--KLMELIINGT---- 109
            |||...||.|   .|...:..|.:..| :|.|:||....|.||..| :|  ||..|..:|.
plant   631 SLKKMDLGCS---NNLKEIPDLSLAIN-LEELNLSKCESLVTLPSSIQNAIKLRTLYCSGVLLID 691

  Fly   110 --------NLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINASH 166
                    ||:.|..|.:.:.  .|.....:|.||:|:            |...|.
plant   692 LKSLEGMCNLEYLSVDWSSME--GTQGLIYLPRKLKRL------------WWDYCP--------- 733

  Fly   167 NRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQ-SNELPSLPDNFFAVTHA 230
                 |..|..|::...||.|.:..:||::|....:...|::.:.|. |..|..:||...|:...
plant   734 -----VKRLPSNFKAEYLVELRMENSDLEKLWDGTQPLGSLKEMYLHGSKYLKEIPDLSLAINLE 793

  Fly   231 RLETLNVSCNKLSTLPRYEQN----------------------NHAALVNLSLAG---------N 264
            ||...  .|..|.|||...||                      |..:|..|:|.|         .
plant   794 RLYLF--GCESLVTLPSSIQNATKLINLDMRDCKKLESFPTDLNLESLEYLNLTGCPNLRNFPAI 856

  Fly   265 HLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAA-----CVRNW------PE-LEILVLSGNMLQQL 317
            .:..|.||.|.:..::.|....:|:  .|||.     |:...      || |..|.:||...::|
plant   857 KMGCSYFEILQDRNEIEVEDCFWNK--NLPAGLDYLDCLMRCMPCEFRPEYLTFLDVSGCKHEKL 919

  Fly   318 PEEVATLGQLRVLRCCNNLLLC-TPQLAKLAMLKVLDLSH--------------NHLDRVNL--- 364
            .|.:.:||.|:.:....:..|. .|.|:|...||.|.|:.              :.|.|:.:
plant   920 WEGIQSLGSLKRMDLSESENLTEIPDLSKATNLKRLYLNGCKSLVTLPSTIGNLHRLVRLEMKEC 984

  Fly   365 --LALVPS----RNLKYLDLSG 380
              |.|:|:    .:|..|||||
plant   985 TGLELLPTDVNLSSLIILDLSG 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	9/33 (27%)
		LRR_8	109..169	CDD:290566	11/71 (15%)
		leucine-rich repeat	111..135	CDD:275380	5/23 (22%)
		leucine-rich repeat	136..158	CDD:275380	4/21 (19%)
		leucine-rich repeat	159..183	CDD:275380	3/23 (13%)
		leucine-rich repeat	184..209	CDD:275380	7/24 (29%)
		LRR_8	205..266	CDD:290566	21/92 (23%)
		leucine-rich repeat	210..230	CDD:275380	6/20 (30%)
		leucine-rich repeat	232..255	CDD:275380	9/44 (20%)
		LRR_RI	<256..410	CDD:238064	44/170 (26%)
		leucine-rich repeat	256..276	CDD:275380	8/28 (29%)
		LRR_8	279..359	CDD:290566	25/106 (24%)
		leucine-rich repeat	280..303	CDD:275380	6/33 (18%)
		leucine-rich repeat	304..348	CDD:275380	13/44 (30%)
		leucine-rich repeat	349..372	CDD:275380	9/45 (20%)
		PP2Cc	461..655	CDD:294085
RPP4	NP_193420.2	PLN03210	13..>1081	CDD:215633	103/412 (25%)
		TIR	13..175	CDD:279864
		AAA_22	206..306	CDD:290137
		LRR_3	608..626	CDD:285026
		leucine-rich repeat	609..631	CDD:275380	103/412 (25%)
		leucine-rich repeat	632..654	CDD:275380	7/24 (29%)
		leucine-rich repeat	655..678	CDD:275380	9/22 (41%)
		leucine-rich repeat	679..700	CDD:275380	3/20 (15%)
		leucine-rich repeat	724..768	CDD:275380	13/69 (19%)
		LRR_3	745..764	CDD:285026	6/18 (33%)
		leucine-rich repeat	746..763	CDD:275380	6/16 (38%)
		leucine-rich repeat	769..791	CDD:275380	6/21 (29%)
		leucine-rich repeat	792..815	CDD:275380	9/24 (38%)
		leucine-rich repeat	816..838	CDD:275380	1/21 (5%)
		leucine-rich repeat	906..928	CDD:275380	7/21 (33%)
		leucine-rich repeat	929..951	CDD:275380	5/21 (24%)
		leucine-rich repeat	952..975	CDD:275380	4/22 (18%)
		leucine-rich repeat	976..998	CDD:275380	5/21 (24%)
		leucine-rich repeat	1021..1042	CDD:275380
		leucine-rich repeat	1043..1066	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000