DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and AT4G12010

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_192938.1	Gene:	AT4G12010 / 826809	AraportID:	AT4G12010	Length:	1219	Species:	Arabidopsis thaliana

Alignment Length:	605	Identity:	133/605 - (21%)
Similarity:	204/605 - (33%)	Gaps:	201/605 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 LKGSQLGGSILIGNYNYLTQLEV--------CENEMEVLDLSSLAQLETLKCSRNKLMELIINGT 109
            |:..:|......|.|| |..|::        ||.|.::.....|:.|.      |:|..|..:|.
plant   551 LRAMRLSAKAFQGMYN-LKYLKIYDSHCSRGCEAEFKLHLRRGLSFLP------NELTYLHWHGY 608

  Fly   110 NLQTLVAD------------HNYLHNISTTNTHPVPLKLQRIDISH-------------NNFSEL 149
            .||::..|            |:.|..|.........||.  :|:||             :|...|
plant   609 PLQSIPLDFDPKNLVDLKLPHSQLEEIWDDEKDVGMLKW--VDLSHSINLRQCLGLANAHNLERL 671

  Fly   150 PNWVGACASLTAINASHNRLNNVAVLLRNYR-ITELVSL----------DLAYNDLKQLDQFPEG 203
             |..| |.||..:.::.|.|..:..|  |.| .|.|.||          .|..:....|.:||..
plant   672 -NLEG-CTSLKKLPSTINCLEKLIYL--NLRDCTSLRSLPKGIKTQSLQTLILSGCSSLKKFPLI 732

  Fly   204 FSSIRSLQLQSNELPSLPDNFFAVTHARLETLNV-------------------------SCNKLS 243
            ..::..|.|....:.|||::.  .|..||..||:                         .|::|.
plant   733 SENVEVLLLDGTVIKSLPESI--QTFRRLALLNLKNCKKLKHLSSDLYKLKCLQELILSGCSQLE 795

  Fly   244 TLPRYEQNNHAALVNL---------------------SLAG--NHLNDSIF--EPLHNAAKLRVL 283
            ..|..:::..:..:.|                     ||.|  :|::.|:|  .|....::|..|
plant   796 VFPEIKEDMESLEILLMDDTSITEMPKMMHLSNIKTFSLCGTSSHVSVSMFFMPPTLGCSRLTDL 860

  Fly   284 HLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAM 348
            :|:...:..||.. :.....|:.|.||||.::.|||....|..|:..    :|..|       .|
plant   861 YLSRCSLYKLPDN-IGGLSSLQSLCLSGNNIENLPESFNQLNNLKWF----DLKFC-------KM 913

  Fly   349 LKVLDLSHNHLDRVNLLALVPSRNLKYLD---------LSGNL-QLQVDEQ-----QFKVCQSQS 398
            ||.|.              |..:||:|||         |:..| .|.|.|:     .|..|...:
plant   914 LKSLP--------------VLPQNLQYLDAHECESLETLANPLTPLTVGERIHSMFIFSNCYKLN 964

  Fly   399 Q-RHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANY 462
            | ...|||   |:.|          :.:|...|.::..:..||...|..|.|            |
plant   965 QDAQASLV---GHAR----------IKSQLMANASAKRYYRGFVPEPLVGIC------------Y 1004

  Fly   463 GGSDEALYGMFEALEGRGRAAQEMSH--------LVPDLMKQEQMVKDSAVRDYMK--------- 510
            ..::...:...:.| ||........|        |...::...:..:|||.|..:|
plant  1005 PATEIPSWFCHQRL-GRSLEIPLPPHWCDINFVGLALSVVVSFKDYEDSAKRFSVKCCGNFENKD 1068

  Fly   511 -------FTLLAAQQQCGSV 523
                   |||....:.|||:
plant  1069 SSFTRFDFTLAGWNEPCGSL 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	5/18 (28%)
		LRR_8	109..169	CDD:290566	19/84 (23%)
		leucine-rich repeat	111..135	CDD:275380	6/35 (17%)
		leucine-rich repeat	136..158	CDD:275380	8/34 (24%)
		leucine-rich repeat	159..183	CDD:275380	6/24 (25%)
		leucine-rich repeat	184..209	CDD:275380	7/34 (21%)
		LRR_8	205..266	CDD:290566	17/108 (16%)
		leucine-rich repeat	210..230	CDD:275380	6/19 (32%)
		leucine-rich repeat	232..255	CDD:275380	6/47 (13%)
		LRR_RI	<256..410	CDD:238064	47/194 (24%)
		leucine-rich repeat	256..276	CDD:275380	8/44 (18%)
		LRR_8	279..359	CDD:290566	22/79 (28%)
		leucine-rich repeat	280..303	CDD:275380	5/22 (23%)
		leucine-rich repeat	304..348	CDD:275380	13/43 (30%)
		leucine-rich repeat	349..372	CDD:275380	4/22 (18%)
		PP2Cc	461..655	CDD:294085	17/87 (20%)
AT4G12010	NP_192938.1	LRR_3	1..1143	CDD:332712	133/605 (22%)
		leucine-rich repeat	600..621	CDD:275380	6/20 (30%)
		leucine-rich repeat	645..667	CDD:275380	5/23 (22%)
		leucine-rich repeat	668..691	CDD:275380	8/24 (33%)
		leucine-rich repeat	692..714	CDD:275380	7/23 (30%)
		leucine-rich repeat	715..758	CDD:275380	10/44 (23%)
		leucine-rich repeat	759..782	CDD:275380	3/22 (14%)
		leucine-rich repeat	783..806	CDD:275380	3/22 (14%)
		leucine-rich repeat	807..856	CDD:275380	8/48 (17%)
		leucine-rich repeat	857..879	CDD:275380	5/22 (23%)
		leucine-rich repeat	880..902	CDD:275380	10/21 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000