DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and RLP45

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001325565.1	Gene:	RLP45 / 824491	AraportID:	AT3G53240	Length:	927	Species:	Arabidopsis thaliana

Alignment Length:	467	Identity:	119/467 - (25%)
Similarity:	189/467 - (40%)	Gaps:	127/467 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LSLKGSQLGGSI--LIGNYNYLTQLEVCENEME-VLDLSSLAQLETLK----CSRNKLMELI--- 105
            |.|..:.|.|.|  .|.::..:..|.:.:|:.| :..|..:.:|..||    .||:.:::::
plant   243 LDLSSNHLSGKIPYFISDFKSMEYLSLLDNDFEGLFSLGLITELTELKVFKLSSRSGMLQIVETN 307

  Fly   106 INGTNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRLN 170
            ::| .||:                     :|..|.:||.|..::|.::.....|..|:.|:|.|:
plant   308 VSG-GLQS---------------------QLSSIMLSHCNLGKIPGFLWYQQELRVIDLSNNILS 350

  Fly   171 NV--AVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLE 233
            .|  ..||.|.  |||.:|.|..|..|.|                     :||.     |..||:
plant   351 GVFPTWLLENN--TELQALLLQNNSFKTL---------------------TLPR-----TMRRLQ 387

  Fly   234 TLNVSCNKLST-LPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRI-GVLP-- 294
            .|::|.|..:. ||:......|:|.:|:|:.|....::...:.....:..:.|:||.. |.||
plant   388 ILDLSVNNFNNQLPKDVGLILASLRHLNLSNNEFLGNMPSSMARMENIEFMDLSYNNFSGKLPRN 452

  Fly   295 --AACVR-NWPELE-------------------ILVLSGNMLQ-QLPEEVATLGQLRVLRCCNNL 336
              ..|.. :|.:|.                   .|::..||.. ::|..:..|..|.|:...|||
plant   453 LFTGCYSLSWLKLSHNRFSGPIIRKSSDETSLITLIMDNNMFTGKIPRTLLNLRMLSVIDLSNNL 517

  Fly   337 LLCT-PQLAKLAMLKVLDLSHNHLDRVNLLALVPSR-NLKY---LDLSGN-----LQLQVDEQQF 391
            |..| |:......|:||.:|:|.|..    |:.||. |:.|   ||||||     |.|:
plant   518 LTGTIPRWLGNFFLEVLRISNNRLQG----AIPPSLFNIPYLWLLDLSGNFLSGSLPLR------ 572

  Fly   392 KVCQSQSQRHWSLVDVSGNN-RAALPTT---KIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKL 452
                 .|..:..::|:..|| ..::|.|   .:|.:.. || ||.||...: |..||      .:
plant   573 -----SSSDYGYILDLHNNNLTGSIPDTLWYGLRLLDL-RN-NKLSGNIPL-FRSTP------SI 623

  Fly   453 SVYQLRAANYGG 464
            ||..||..|..|
plant   624 SVVLLRENNLTG 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	6/25 (24%)
		LRR_8	109..169	CDD:290566	12/59 (20%)
		leucine-rich repeat	111..135	CDD:275380	2/23 (9%)
		leucine-rich repeat	136..158	CDD:275380	6/21 (29%)
		leucine-rich repeat	159..183	CDD:275380	9/25 (36%)
		leucine-rich repeat	184..209	CDD:275380	6/24 (25%)
		LRR_8	205..266	CDD:290566	15/61 (25%)
		leucine-rich repeat	210..230	CDD:275380	3/19 (16%)
		leucine-rich repeat	232..255	CDD:275380	6/23 (26%)
		LRR_RI	<256..410	CDD:238064	47/189 (25%)
		leucine-rich repeat	256..276	CDD:275380	4/19 (21%)
		LRR_8	279..359	CDD:290566	27/106 (25%)
		leucine-rich repeat	280..303	CDD:275380	8/28 (29%)
		leucine-rich repeat	304..348	CDD:275380	14/64 (22%)
		leucine-rich repeat	349..372	CDD:275380	9/23 (39%)
		PP2Cc	461..655	CDD:294085	2/4 (50%)
RLP45	NP_001325565.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910