DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and BRL3

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_187946.1	Gene:	BRL3 / 820538	AraportID:	AT3G13380	Length:	1164	Species:	Arabidopsis thaliana

Alignment Length:	525	Identity:	134/525 - (25%)
Similarity:	215/525 - (40%)	Gaps:	126/525 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KLKVSASHSGPHPLPVEVT--AAEEEQAATFGQTSPQKLSLKGSQLGGSILIGNYNYLTQLEVCE 77
            |||.|.|.|......|:::  ...:|...||....|.  |||...|.|:.:.|:::.|: ..:||
plant   165 KLKSSPSASNKRITTVDLSNNRFSDEIPETFIADFPN--SLKHLDLSGNNVTGDFSRLS-FGLCE 226

  Fly    78 NEMEVLDLSSLAQ-----------------LETLKCSRNKLMELII------NGTNLQTLVADHN 119
            |    |.:.||:|                 ||||..|||.|:..|.      |..||:.|...||
plant   227 N----LTVFSLSQNSISGDRFPVSLSNCKLLETLNLSRNSLIGKIPGDDYWGNFQNLRQLSLAHN 287

  Fly   120 -YLHNISTTNTHPVPLK-----LQRIDISHNNFS-ELPNWVGACASLTAINASHNRLNNVAVLLR 177
             |...|      |..|.     |:.:|:|.|:.: :||....:|.||.::|..:|:|:...:...
plant   288 LYSGEI------PPELSLLCRTLEVLDLSGNSLTGQLPQSFTSCGSLQSLNLGNNKLSGDFLSTV 346

  Fly   178 NYRITELVSLDLAYNDLKQLDQFP---EGFSSIRSLQLQSNELP-SLPDNFFAV-THARLETLNV 237
            ..:::.:.:|.|.:|::.  ...|   ...|::|.|.|.|||.. .:|..|.:: :.:.||.|.:
plant   347 VSKLSRITNLYLPFNNIS--GSVPISLTNCSNLRVLDLSSNEFTGEVPSGFCSLQSSSVLEKLLI 409

  Fly   238 SCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHL-AYNRIGVLPAACVRNW 301
            :.|.||.....|.....:|..:.|:.|.|...|.:.:....||..|.: |.|..|.:|.:...:.
plant   410 ANNYLSGTVPVELGKCKSLKTIDLSFNALTGLIPKEIWTLPKLSDLVMWANNLTGGIPESICVDG 474

  Fly   302 PELEILVLSGNMLQ-QLPEEVATLGQLRVLRCCNNLLLCTPQ----LAKLAMLKVLDLSHNHLDR 361
            ..||.|:|:.|:|. .|||.::....:..:...:|||  |.:    :.||..|.:|.|.:|
plant   475 GNLETLILNNNLLTGSLPESISKCTNMLWISLSSNLL--TGEIPVGIGKLEKLAILQLGNN---- 533

  Fly   362 VNLLALVPS-----RNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIR 421
             :|...:||     :||.:|||:.|                        :::||    ||    .
plant   534 -SLTGNIPSELGNCKNLIWLDLNSN------------------------NLTGN----LP----G 565

  Fly   422 QVSAQRN---QNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAA 483
            ::::|..   ....||. ...|....|..|||          ..||          .:|..|..|
plant   566 ELASQAGLVMPGSVSGK-QFAFVRNEGGTDCR----------GAGG----------LVEFEGIRA 609

  Fly   484 QEMSH 488
            :.:.|
plant   610 ERLEH 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	10/24 (42%)
		LRR_8	109..169	CDD:290566	20/66 (30%)
		leucine-rich repeat	111..135	CDD:275380	7/24 (29%)
		leucine-rich repeat	136..158	CDD:275380	7/22 (32%)
		leucine-rich repeat	159..183	CDD:275380	4/23 (17%)
		leucine-rich repeat	184..209	CDD:275380	5/27 (19%)
		LRR_8	205..266	CDD:290566	19/62 (31%)
		leucine-rich repeat	210..230	CDD:275380	7/21 (33%)
		leucine-rich repeat	232..255	CDD:275380	7/22 (32%)
		LRR_RI	<256..410	CDD:238064	40/164 (24%)
		leucine-rich repeat	256..276	CDD:275380	5/19 (26%)
		LRR_8	279..359	CDD:290566	26/85 (31%)
		leucine-rich repeat	280..303	CDD:275380	6/23 (26%)
		leucine-rich repeat	304..348	CDD:275380	15/48 (31%)
		leucine-rich repeat	349..372	CDD:275380	7/27 (26%)
		PP2Cc	461..655	CDD:294085	6/28 (21%)
BRL3	NP_187946.1	PLN00113	32..1123	CDD:215061	134/525 (26%)
		leucine-rich repeat	81..102	CDD:275380
		leucine-rich repeat	126..151	CDD:275380
		leucine-rich repeat	152..176	CDD:275380	6/10 (60%)
		leucine-rich repeat	177..202	CDD:275380	5/26 (19%)
		leucine-rich repeat	203..227	CDD:275380	7/24 (29%)
		leucine-rich repeat	228..252	CDD:275380	4/23 (17%)
		leucine-rich repeat	279..303	CDD:275380	8/29 (28%)
		leucine-rich repeat	304..327	CDD:275380	7/22 (32%)
		leucine-rich repeat	328..352	CDD:275380	4/23 (17%)
		leucine-rich repeat	353..376	CDD:275380	4/24 (17%)
		leucine-rich repeat	377..400	CDD:275380	8/22 (36%)
		leucine-rich repeat	404..427	CDD:275380	7/22 (32%)
		leucine-rich repeat	428..451	CDD:275380	5/22 (23%)
		leucine-rich repeat	452..476	CDD:275380	6/23 (26%)
		leucine-rich repeat	477..500	CDD:275380	9/22 (41%)
		leucine-rich repeat	501..524	CDD:275380	6/24 (25%)
		leucine-rich repeat	525..546	CDD:275380	7/25 (28%)
		leucine-rich repeat	549..640	CDD:275380	23/119 (19%)
		leucine-rich repeat	641..664	CDD:275380
		leucine-rich repeat	665..688	CDD:275380
		leucine-rich repeat	689..712	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910