DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and PIRL9

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_187741.2	Gene:	PIRL9 / 820306	AraportID:	AT3G11330	Length:	499	Species:	Arabidopsis thaliana

Alignment Length:	633	Identity:	123/633 - (19%)
Similarity:	218/633 - (34%)	Gaps:	224/633 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KQADPYKSKLKVSASHSGPHPLPVEVTAAEEEQAATFGQT--------------SPQKLSLKGSQ 57
            :|..|..|...:......||....:|.|:.....:...:|              |..|...|.|:
plant    38 EQPPPSSSSSSIEIVTQMPHLTQPDVLASMTSAISDVAETRSILRTLGPRPDHESVDKARAKLSE 102

  Fly    58 LGGSILIGNYNYLTQLEVC--------ENEMEVLDLSSLAQLETLKCSRNKLM----ELII---- 106
            : .|.|..::..:...:..        |.:.|.....|:.:|:.:..|..||:    |.::
plant   103 I-ESFLSESFEDIALTDAAAKDEKRRQEMDQEKTWCESILKLDEVHASYEKLLKEAEERLVRIYE 166

  Fly   107 --------NGTNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAIN 163
                    :..|:..:..:...:..:...:.:||    .|:|:|......||...|....|..:|
plant   167 SAEKNAAEDEENVAAVEVNEEVVGILQHASANPV----DRVDLSGRKLRLLPEAFGRIQGLLVLN 227

  Fly   164 ASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPE---GFSSIRSLQLQSNELPSLPDNFF 225
            .|:|:|.::                            |:   |..|:..|.:.:|.|.:|||:..
plant   228 LSNNKLESI----------------------------PDSIAGLHSLVELDVSTNSLETLPDSIG 264

  Fly   226 AVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRI 290
            .:  ::|:.||||.|||::||                     |||.    ....|.:|.:::||:
plant   265 LL--SKLKILNVSTNKLTSLP---------------------DSIC----RCGSLVILDVSFNRL 302

  Fly   291 GVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLS 355
            ..||.........||.|::..|.::..|   .::|::|                   .||.||.
plant   303 TYLPTNIGPELVNLEKLLVQYNKIRSFP---TSIGEMR-------------------SLKHLDA- 344

  Fly   356 HNHLDRVNLL--ALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTT 418
              |.:.:|.|  :.|...||:||:||.|.. .:.:..|...:..|.:.   :|:|.|...|||
plant   345 --HFNELNGLPDSFVLLTNLEYLNLSSNFS-DLKDLPFSFGELISLQE---LDLSNNQIHALP-- 401

  Fly   419 KIRQVSAQRNQNKTSGPWTMGFAETPGSGD-CRKLSVYQLRAANYGGSDEALYGMFEALEGRGRA 482
                                   :|.|:.| ..||:|.|
plant   402 -----------------------DTFGTLDSLTKLNVDQ-------------------------- 417

  Fly   483 AQEMSHLVPDLMKQEQMVKD--SAVRDYM---KFTLLAAQQQCGSVRSAALFHLTRTRAPSKVRP 542
                   .|.::..|::||:  .||:.||   :.::|..:::
plant   418 -------NPLVVPPEEVVKEGVEAVKTYMGQRRISMLEEEEK----------------------- 452

  Fly   543 LKSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHV 590
             |.....:..|:.|    :|.|.||:|:....||.:....:|..||::
plant   453 -KKMEEEMEQANAG----WLTRTTSKLKTYVADVSEYLGSNSPRDPYL 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	5/34 (15%)
		LRR_8	109..169	CDD:290566	13/59 (22%)
		leucine-rich repeat	111..135	CDD:275380	2/23 (9%)
		leucine-rich repeat	136..158	CDD:275380	6/21 (29%)
		leucine-rich repeat	159..183	CDD:275380	5/23 (22%)
		leucine-rich repeat	184..209	CDD:275380	3/27 (11%)
		LRR_8	205..266	CDD:290566	17/60 (28%)
		leucine-rich repeat	210..230	CDD:275380	6/19 (32%)
		leucine-rich repeat	232..255	CDD:275380	10/22 (45%)
		LRR_RI	<256..410	CDD:238064	35/155 (23%)
		leucine-rich repeat	256..276	CDD:275380	3/19 (16%)
		LRR_8	279..359	CDD:290566	17/79 (22%)
		leucine-rich repeat	280..303	CDD:275380	6/22 (27%)
		leucine-rich repeat	304..348	CDD:275380	7/43 (16%)
		leucine-rich repeat	349..372	CDD:275380	8/24 (33%)
		PP2Cc	461..655	CDD:294085	22/135 (16%)
PIRL9	NP_187741.2	leucine-rich repeat	202..222	CDD:275380	6/19 (32%)
		LRR_RI	205..397	CDD:238064	64/275 (23%)
		LRR_8	222..279	CDD:290566	20/86 (23%)
		leucine-rich repeat	223..245	CDD:275380	7/49 (14%)
		leucine-rich repeat	246..268	CDD:275380	6/23 (26%)
		leucine-rich repeat	269..291	CDD:275380	13/46 (28%)
		leucine-rich repeat	292..315	CDD:275380	6/22 (27%)
		LRR_8	315..370	CDD:290566	21/79 (27%)
		leucine-rich repeat	316..338	CDD:275380	7/43 (16%)
		leucine-rich repeat	339..361	CDD:275380	8/24 (33%)
		LRR_8	360..420	CDD:290566	22/121 (18%)
		leucine-rich repeat	362..386	CDD:275380	7/24 (29%)
		leucine-rich repeat	387..409	CDD:275380	8/49 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45752
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100