DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and RLP32

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_187216.1	Gene:	RLP32 / 819732	AraportID:	AT3G05650	Length:	868	Species:	Arabidopsis thaliana

Alignment Length:	646	Identity:	132/646 - (20%)
Similarity:	219/646 - (33%)	Gaps:	248/646 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 AATFGQTSPQKLSLKGSQLGGSILIGNY---NYLTQLEVCEN--------------EMEVLDLS- 86
            ::.|...|...::|:.:||.|::..||.   :.||.|::..|              .::.||||
plant   256 SSLFTIASLTSINLRNNQLNGTLEFGNISSPSTLTVLDISNNNFIGPIPKSISKFINLQDLDLSH 320

  Fly    87 -------------SLAQLETLKCSR---------NKLMELIINGTNLQTLVADH-NYLHNISTTN 128
                         :|..|:.|..|.         |.|....:|......|..:| :....||..:
plant   321 LNTQGPVDFSIFTNLKSLQLLNLSHLNTTTTIDLNALFSSHLNSIYSMDLSGNHVSATTKISVAD 385

  Fly   129 THPVPL----------------------KLQRIDISHNNF-SELPNWVGACASLTAINASHNRL- 169
            .||..|                      |:..:|||:|.. .::|.|:.....|..::.|:|..
plant   386 HHPTQLISQLYLSGCGITEFPELLRSQHKMTNLDISNNKIKGQVPGWLWTLPKLIFVDLSNNIFT 450

  Fly   170 -------------------------NNVAVLLRNY--RITELVSLDLAYNDLK------------ 195
                                     ||....:.::  .:..|::|||:.|:|.
plant   451 GFERSTEHGLSLITKPSMQYLVGSNNNFTGKIPSFICALRSLITLDLSDNNLNGSIPPCMGNLKS 515

  Fly   196 -----QLDQFPEG-------FSSIRSLQLQSNEL-PSLPDNFFAVTHARLETLNVSCNKLSTLPR 247
                 .|.|...|       |.|:|||.:..|:| ..||.:|..:  :.||.|||..|:::....
plant   516 TLSFLNLRQNRLGGGLPRSIFKSLRSLDVGHNQLVGKLPRSFIRL--SALEVLNVENNRINDTFP 578

  Fly   248 YEQNNHAALVNLSLAGNHLNDSIFEPLHNAA--KLRVLHLAYNRI-GVLPAACVRNWP------- 302
            :..::...|..|.|..|    :...|:|:|:  .||:::|::|:. |.|||....||.
plant   579 FWLSSLKKLQVLVLRSN----AFHGPIHHASFHTLRIINLSHNQFSGTLPANYFVNWNAMSSLMA 639

  Fly   303 ----------------------------ELEI---------LVLSGNMLQ-QLPEEVATLGQLRV 329
                                        |:|:         |..|.|.|: ::|..:..|.:|.|
plant   640 TEDRSQEKYMGDSFRYYHDSVVLMNKGLEMELVRILKIYTALDFSENKLEGEIPRSIGLLKELHV 704

  Fly   330 LRCCNNLLL--CTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSR--NLKYLDLSGNLQLQVDEQQ 390
            |...:|...  ....:..|..|:.||:|.|.|.     ..:|..  ||.||
plant   705 LNLSSNAFTGHIPSSMGNLRELESLDVSQNKLS-----GEIPQELGNLSYL-------------- 750

  Fly   391 FKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVY 455
                        :.::.|.|....|    :...:..|.||.:|      |.:.||.
plant   751 ------------AYMNFSHNQLGGL----VPGGTQFRRQNCSS------FKDNPGL--------- 784

  Fly   456 QLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAA 516
                  ||.|.|.:     .|:....|.|:  |..|:|.::::.|          |:.:||
plant   785 ------YGSSLEEV-----CLDIHAPAPQQ--HEPPELEEEDREV----------FSWIAA 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	6/27 (22%)
		LRR_8	109..169	CDD:290566	17/83 (20%)
		leucine-rich repeat	111..135	CDD:275380	7/46 (15%)
		leucine-rich repeat	136..158	CDD:275380	6/22 (27%)
		leucine-rich repeat	159..183	CDD:275380	5/51 (10%)
		leucine-rich repeat	184..209	CDD:275380	11/48 (23%)
		LRR_8	205..266	CDD:290566	19/61 (31%)
		leucine-rich repeat	210..230	CDD:275380	6/20 (30%)
		leucine-rich repeat	232..255	CDD:275380	6/22 (27%)
		LRR_RI	<256..410	CDD:238064	42/205 (20%)
		leucine-rich repeat	256..276	CDD:275380	5/19 (26%)
		LRR_8	279..359	CDD:290566	28/127 (22%)
		leucine-rich repeat	280..303	CDD:275380	10/58 (17%)
		leucine-rich repeat	304..348	CDD:275380	12/55 (22%)
		leucine-rich repeat	349..372	CDD:275380	7/24 (29%)
		PP2Cc	461..655	CDD:294085	14/56 (25%)
RLP32	NP_187216.1	LRRNT_2	42..86	CDD:311940
		PLN00113	70..>787	CDD:331614	119/592 (20%)
		leucine-rich repeat	121..144	CDD:275380
		leucine-rich repeat	145..168	CDD:275380
		leucine-rich repeat	169..191	CDD:275380
		leucine-rich repeat	192..215	CDD:275380
		leucine-rich repeat	216..263	CDD:275380	1/6 (17%)
		leucine-rich repeat	264..288	CDD:275380	6/23 (26%)
		leucine-rich repeat	289..312	CDD:275380	4/22 (18%)
		leucine-rich repeat	313..337	CDD:275380	5/23 (22%)
		leucine-rich repeat	367..390	CDD:275380	6/22 (27%)
		leucine-rich repeat	391..414	CDD:275380	1/22 (5%)
		leucine-rich repeat	415..438	CDD:275380	6/22 (27%)
		leucine-rich repeat	439..467	CDD:275380	3/27 (11%)
		leucine-rich repeat	468..491	CDD:275380	2/22 (9%)
		leucine-rich repeat	492..515	CDD:275380	6/22 (27%)
		leucine-rich repeat	517..538	CDD:275380	4/20 (20%)
		leucine-rich repeat	539..562	CDD:275380	8/24 (33%)
		leucine-rich repeat	563..586	CDD:275380	6/22 (27%)
		leucine-rich repeat	609..636	CDD:275380	10/26 (38%)
		leucine-rich repeat	637..701	CDD:275380	8/63 (13%)
		leucine-rich repeat	702..725	CDD:275380	5/22 (23%)
		leucine-rich repeat	726..749	CDD:275380	9/27 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910