DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and RLP28

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_180867.1	Gene:	RLP28 / 817870	AraportID:	AT2G33080	Length:	740	Species:	Arabidopsis thaliana

Alignment Length:	492	Identity:	106/492 - (21%)
Similarity:	169/492 - (34%)	Gaps:	169/492 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LSLKGSQLGGSILIGNYNYLTQLEVCENEMEVLDLSSLAQLETLKCSRNKLMELIIN---GTNLQ 112
            |:|.|:...|||.:...:.|..|.:.....|...|..:::|..||  |.:|..|.|:   ..||.
plant   201 LNLYGNHFTGSIEVSTSSKLEILYLGLKPFEGQILEPISKLINLK--RLELSFLNISYPLDLNLF 263

  Fly   113 TLVADHNYLHNISTTNTHP--------VPL-----------------------KLQRIDISHNNF 146
            :.:....|| ::|..:..|        :||                       ||:.||:|:|..
plant   264 SSLKSLTYL-DLSGNSISPRSLRSDLYIPLTLEKLLLEQCGIIEFPNILKTLQKLEYIDMSNNRI 327

  Fly   147 S-ELPNWVGACASLTAINASHNRL----------------------NNVAVLLRNYRI------- 181
            : ::|.|:.....|.:::.::|..                      ||:...|.|..:
plant   328 NGKIPEWLWRLPRLRSMSLANNSFNGFEGSTDVLVNSSMEILFMHSNNIQGALPNLPLSIKAFSA 392

  Fly   182 ----------------TELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELP-SLPDNFFAVTH 229
                            :.|.:|.|.||:.  ..:.|:..|::..:.|:.|.|. |:||...|  .
plant   393 GYNNFSGEIPLSICNRSSLAALSLPYNNF--TGKIPQCLSNLTFVHLRKNNLEGSIPDTLCA--G 453

  Fly   230 ARLETLNVSCNKLS-TLPRYEQNNHAALVNLSLAGNHLNDSI----------------------- 270
            ..|:||::..|.:| |||| ...|.::|..||:..|.:.|:.
plant   454 DSLQTLDIGFNLISGTLPR-SLLNCSSLEFLSVDNNRIKDTFPFWLKALPNLQVLILSSNKLYGP 517

  Fly   271 FEPLHNA----AKLRVLHLAYNRI-GVLPAACVRNWPELEILV---------------------- 308
            ..|.|.:    .:||:..:|.|.. |.|......||....:.|
plant   518 IAPPHQSPLAFPELRIFEIADNMFTGTLSPRYFVNWKTSSLTVNEDGDLYMVYKNNAFGIDSYVY 582

  Fly   309 --------------------------LSGNMLQ-QLPEEVATLGQLRVLRCCNNLLLC-TP-QLA 344
                                      .|||.|: |:|:.:..|.:|..|...||...| .| .||
plant   583 RDTIDMKYKGLSMEQQMVLNSYSAIDFSGNRLEGQIPKSIGLLKELIALNLSNNAFTCHIPLSLA 647

  Fly   345 KLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGN 381
            ....|:.||||.|.|.......|.....|.|:::|.|
plant   648 NATELESLDLSRNQLSGTIPNGLKTLSFLAYINVSHN 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	7/21 (33%)
		LRR_8	109..169	CDD:290566	18/91 (20%)
		leucine-rich repeat	111..135	CDD:275380	7/54 (13%)
		leucine-rich repeat	136..158	CDD:275380	7/22 (32%)
		leucine-rich repeat	159..183	CDD:275380	6/68 (9%)
		leucine-rich repeat	184..209	CDD:275380	7/24 (29%)
		LRR_8	205..266	CDD:290566	22/62 (35%)
		leucine-rich repeat	210..230	CDD:275380	7/20 (35%)
		leucine-rich repeat	232..255	CDD:275380	10/23 (43%)
		LRR_RI	<256..410	CDD:238064	43/205 (21%)
		leucine-rich repeat	256..276	CDD:275380	6/42 (14%)
		LRR_8	279..359	CDD:290566	30/131 (23%)
		leucine-rich repeat	280..303	CDD:275380	8/23 (35%)
		leucine-rich repeat	304..348	CDD:275380	16/94 (17%)
		leucine-rich repeat	349..372	CDD:275380	8/22 (36%)
		PP2Cc	461..655	CDD:294085
RLP28	NP_180867.1	LRR_8	101..161	CDD:290566
		leucine-rich repeat	102..126	CDD:275380
		LRR_RI	<118..279	CDD:238064	22/80 (28%)
		leucine-rich repeat	127..150	CDD:275380
		LRR_8	149..208	CDD:290566	3/6 (50%)
		leucine-rich repeat	151..173	CDD:275380
		leucine-rich repeat	174..197	CDD:275380
		leucine-rich repeat	198..243	CDD:275380	11/41 (27%)
		leucine-rich repeat	244..268	CDD:275380	8/25 (32%)
		leucine-rich repeat	269..292	CDD:275380	4/23 (17%)
		LRR_8	293..351	CDD:290566	10/57 (18%)
		leucine-rich repeat	294..316	CDD:275380	0/21 (0%)
		leucine-rich repeat	317..340	CDD:275380	7/22 (32%)
		LRR_RI	<332..514	CDD:238064	37/186 (20%)
		leucine-rich repeat	432..455	CDD:275380	7/24 (29%)
		LRR_8	455..514	CDD:290566	15/59 (25%)
		leucine-rich repeat	456..479	CDD:275380	10/23 (43%)
		leucine-rich repeat	480..501	CDD:275380	5/20 (25%)
		leucine-rich repeat	531..603	CDD:275380	9/71 (13%)
		leucine-rich repeat	604..627	CDD:275380	7/22 (32%)
		leucine-rich repeat	628..651	CDD:275380	8/22 (36%)
		leucine-rich repeat	652..675	CDD:275380	8/22 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010