DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and AT2G17050

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001324491.1	Gene:	AT2G17050 / 816210	AraportID:	AT2G17050	Length:	1386	Species:	Arabidopsis thaliana

Alignment Length:	805	Identity:	154/805 - (19%)
Similarity:	270/805 - (33%)	Gaps:	301/805 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 QKLSLKGSQLGGSILIGNYNYLTQLEVCENEMEV--LDLSSL---AQLETLKCSRNKLMELIING 108
            ::..|||...|.:                .::||  ||:|:|   .:.:..| |.:.|..|.|..
plant   347 EETKLKGESKGTT----------------EDIEVIFLDMSNLKFFVKPDAFK-SMHNLRFLKIYS 394

  Fly   109 TN------------LQTLVADHNYLH----NISTTNTHPVPLKLQRIDISHNNFSELPNWVGA-- 155
            :|            ||:|..:...||    .:.:...|..|..|..:::.::...:|  |.|.
plant   395 SNPGKHQRIRFREALQSLPNELRLLHWEDYPLQSLPQHFDPTHLVELNMPYSKLQKL--WGGTKN 457

  Fly   156 CASLTAINASHNR-LNNVAVLLRNYRITELVSLDLAYNDLKQLDQFP-------------EGFSS 206
            ...|..:..||:: |..:..|:::..| |::.|    ....::..||             .|...
plant   458 LEMLKMVRLSHSQDLVEIEELIKSKNI-EVIDL----QGCTKIQSFPATRHLQHLRVINLSGCVE 517

  Fly   207 IRSLQLQSNELPSLPDN----FFAVTHAR----------LETLNVS-CNKLSTLPRYEQNNHAAL 256
            |:|.||:  |....|.|    :.:.|..|          ||.|::| |.:|..|| ..:.|.|:|
plant   518 IKSTQLE--EFQGFPRNLKELYLSGTGIREVTSSIHLSSLEVLDLSNCKRLQNLP-MGKGNLASL 579

  Fly   257 VNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAA--------------CVR-------- 299
            :.|.|:|.....:|.:...|   |:.|:||...|..:|::              |.:
plant   580 IKLMLSGCSKLQNIQDLPTN---LKELYLAGTSIREVPSSICHLTQLVVFDAENCKKLQDLPMGM 641

  Fly   300 -NWPELEILVLSG-NMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLA-----MLKVLDLSHN 357
             |...|.:|:||| :.|:.:|:....|..|.:..        || :.||.     :.|::.|..|
plant   642 GNLISLTMLILSGCSELRSIPDLPRNLRHLNLAE--------TP-IKKLPSSFEDLTKLVSLDLN 697

  Fly   358 HLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQ 422
            |.:|:..|.:....::..:||||.|:|:
plant   698 HCERLQHLQMESFESVVRVDLSGCLELK------------------------------------- 725

  Fly   423 VSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEA-LYG--------MFEALEG 478
                         :.:||            |:..:...:..|:|:. |:|        :.|....
plant   726 -------------YILGF------------SLQDITQLHEDGTDKVMLHGTPPCNVTLILETWRT 765

  Fly   479 RGRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAALFHLTRTRAPSKVRPL 543
            |        |:.|        ::.|..:.|:|............::|:.:|     |..:.|...
plant   766 R--------HVTP--------MEKSGSKFYLKLMPFVTTPYRSKLQSSLVF-----RMYAMVSLF 809

  Fly   544 KSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHVLELILSNDDEYLVVGNAQ 608
            .||.|:|                                    |.|:.:.|            ..
plant   810 LSKAYLL------------------------------------DIHIPQEI------------CN 826

  Fly   609 LWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFRHLGTDVDHLIRELKQSV 673
            |.|:..:|.:.....|...|:          :.|...|||  |:...::|            :|:
plant   827 LLSLKTLDLSGNNFGKLPESI----------KQFRNLESL--ILCHCKNL------------ESL 867

  Fly   674 RKKPQPVSLPLSSGSVCKRTCCDRSNACRHRAIEQEPLAGRSSPSGQSDRDLLAKDKDDEFVLAH 738
            .:.||.:....:.|.||.:..        ||:.:|.|.....|...:...|::.:       :..
plant   868 PELPQSLEFLNAHGCVCLKNI--------HRSFQQFPRHCTFSNCFEISPDIVRE-------ILE 917

  Fly   739 ARVLQE--EQQLEMLDETESVSESV 761
            |||.|.  :..|:.|.|..:.|.||
plant   918 ARVAQMVIDHTLQKLIEAPAFSFSV 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	5/18 (28%)
		LRR_8	109..169	CDD:290566	15/78 (19%)
		leucine-rich repeat	111..135	CDD:275380	7/27 (26%)
		leucine-rich repeat	136..158	CDD:275380	4/23 (17%)
		leucine-rich repeat	159..183	CDD:275380	6/24 (25%)
		leucine-rich repeat	184..209	CDD:275380	5/37 (14%)
		LRR_8	205..266	CDD:290566	23/75 (31%)
		leucine-rich repeat	210..230	CDD:275380	6/23 (26%)
		leucine-rich repeat	232..255	CDD:275380	9/23 (39%)
		LRR_RI	<256..410	CDD:238064	39/182 (21%)
		leucine-rich repeat	256..276	CDD:275380	5/19 (26%)
		LRR_8	279..359	CDD:290566	24/108 (22%)
		leucine-rich repeat	280..303	CDD:275380	8/45 (18%)
		leucine-rich repeat	304..348	CDD:275380	13/49 (27%)
		leucine-rich repeat	349..372	CDD:275380	6/22 (27%)
		PP2Cc	461..655	CDD:294085	32/202 (16%)
AT2G17050	NP_001324491.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000