DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and SHOC2

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_001311265.1 Gene:SHOC2 / 8036 HGNCID:15454 Length:582 Species:Homo sapiens


Alignment Length:542 Identity:128/542 - (23%)
Similarity:191/542 - (35%) Gaps:180/542 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 NYNYLTQLEVC--ENEMEVLDLS------------SLAQLETLKCSRNKLMELIING---TNLQT 113
            |...:.:|..|  ||.|. ||||            .|.||..|....|||..|....   .||.|
Human    87 NAEVIKELNKCREENSMR-LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMT 150

  Fly   114 LVADHNYLHNI--STTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLL 176
            |....|.|.::  |..|..    ||:.:|:.||...|:|:.|....|||.:....||:..|...:
Human   151 LALSENSLTSLPDSLDNLK----KLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDI 211

  Fly   177 RNY---------------------RITELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSL 220
            :|.                     .:..|::||:|:|.|:.|.:.....:.|.:|.||.|||..|
Human   212 KNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDL 276

  Fly   221 PD---NFFAVTH------------------ARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGN 264
            ||   |..:::.                  :.||.||:..|.:||||....::...|.:|:||.|
Human   277 PDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARN 341

  Fly   265 HL------NDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVR-----------------------N 300
            ..      ..|.|..:::      |::.:|||..:|.....                       .
Human   342 CFQLYPVGGPSQFSTIYS------LNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGT 400

  Fly   301 WPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQ-LAKLAMLKVLDLSHNHLDRV-- 362
            |..:..|.|:.|.|.::||:|:.|..|.||...||||...|. |..|..|:.|||..|.|:.:  
Human   401 WTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPN 465

  Fly   363 ---------------NLLALVPS-----RNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDV 407
                           |.|..:|.     .||.:|.|..||...:.|:               :..
Human   466 EIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEE---------------IGT 515

  Fly   408 SGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGM 472
            ..|         :.::....|.|..|.|:.:..        |.|||:..:...            
Human   516 LEN---------LEELYLNDNPNLHSLPFELAL--------CSKLSIMSIENC------------ 551

  Fly   473 FEALEGRGRAAQEMSHLVPDLM 494
                        .:|||.|.::
Human   552 ------------PLSHLPPQIV 561

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380 6/21 (29%)
LRR_8 109..169 CDD:290566 20/61 (33%)
leucine-rich repeat 111..135 CDD:275380 7/25 (28%)
leucine-rich repeat 136..158 CDD:275380 7/21 (33%)
leucine-rich repeat 159..183 CDD:275380 6/44 (14%)
leucine-rich repeat 184..209 CDD:275380 8/24 (33%)
LRR_8 205..266 CDD:290566 25/81 (31%)
leucine-rich repeat 210..230 CDD:275380 10/40 (25%)
leucine-rich repeat 232..255 CDD:275380 9/22 (41%)
LRR_RI <256..410 CDD:238064 47/205 (23%)
leucine-rich repeat 256..276 CDD:275380 7/25 (28%)
LRR_8 279..359 CDD:290566 29/103 (28%)
leucine-rich repeat 280..303 CDD:275380 6/45 (13%)
leucine-rich repeat 304..348 CDD:275380 18/44 (41%)
leucine-rich repeat 349..372 CDD:275380 9/44 (20%)
PP2Cc 461..655 CDD:294085 4/34 (12%)