DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and si:dkey-37g12.1

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_021333677.1	Gene:	si:dkey-37g12.1 / 796669	ZFINID:	ZDB-GENE-090312-145	Length:	882	Species:	Danio rerio

Alignment Length:	884	Identity:	163/884 - (18%)
Similarity:	297/884 - (33%)	Gaps:	281/884 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 QTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLL 176
            ||..|:||   ||:......:...|.:  .|.:|:|.:.|.:...|.:..|:| |.::  |..||
Zfish    32 QTYQAEHN---NITVAKYQDIHSSLSQ--GSTSNWSRVLNEMAQVARIIVISA-HGKV--VRSLL 88

  Fly   177 RNYRITELVSLDLAY--------------NDLKQLDQF----PEGFSSIRSLQL---QSNELPSL 220
            .......|.:.|..:              .|.:|.|.:    .:.:.::..|.|   ......:.
Zfish    89 IEAHKKGLTNGDFVFFCFEPYKQKVLFGSFDWEQGDSYDSMAKQAYQALFFLSLYKPSDKRYQAF 153

  Fly   221 PDNF-------FAVTHARLETLNVSCNKLSTLPRYEQNNHAALVN--LSLAGNHLNDSIFEPLHN 276
            .:|.       |..|:|:.|       |:|.|        ||:.:  :.|..:.||:::.|..:.
Zfish   154 SENVISRSKIDFGYTYAQTE-------KVSVL--------AAIAHDTVWLYAHALNETLAENGNP 203

  Fly   277 AAKLRVLHLAYNRI--GV-----LPAACVRNWPELEILVL----SGNMLQQLPEEVATLGQLRVL 330
            ...|.|....:||.  |:     :.|:..|   ||..::.    |.|..|.:.....|...::.:
Zfish   204 YDGLAVTRRMWNRTIKGIQGDVTIDASGDR---ELNYMMKQIRGSNNQCQVVANYFGTYKAVKGV 265

  Fly   331 R----------------CCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLS 379
            :                |.....||.                 :|:|..|:||   ..:..|..:
Zfish   266 QILWPGGLTSPPKDSPDCGFRGELCI-----------------NLERKFLIAL---GIIAGLMAA 310

  Fly   380 GNLQLQVDEQQFKVCQSQSQRHWSL----VDVSGNNRAALPTTKIRQVSAQRN--------QNKT 432
            |.|.:.|..:::|:.:..|:..|::    |.:..::.:.:|....|....|.:        |:|.
Zfish   311 GTLAICVLYRKYKLPEEASKMLWTINANDVIMMEHHSSTVPEKSHRSKPLQASLESIICSMQDKP 375

  Fly   433 SGPWTMGFAETPGSGDCRKLSVYQLRAANYGGS---------DEALYGMFEALEGRGRAAQE--M 486
            |...|..:     .|....:|...||:.:....         |...|.:.:.:......:|.  :
Zfish   376 SAHRTAVY-----KGTICSVSFVNLRSTHLNSELLAELKQFRDLTHYNLCKFIGAALETSQPFIL 435

  Fly   487 SHLVPDLMKQEQMVKDSAVRDY-MKFTLL------------AAQQQCGSVRSAALFHLTRTRAPS 538
            :...|....|:.:..:|...|: .||:|:            :..|..|.:.|::.
Zfish   436 TEYCPKGSLQDILQNESIKLDWTFKFSLMLDIVKGMDYLHHSPLQYHGHLSSSSC---------- 490

  Fly   539 KVRPLKSKRYVLRMASTG-------------GLD---AYLIRRTSQLRLTKP-DVIQKDQIHSMP 586
                :...|:||::...|             |.|   |.|.|....||.:.| :..||..::|.
Zfish   491 ----VVDSRFVLKVTDFGLNSVRRLDTEQSPGSDPWTALLWRAPELLRQSIPANGTQKGDVYSF- 550

  Fly   587 DPHVLELILSNDDEY----LVVGNAQLWSVMDIDRAAREI--RKEENSLLAAKRLVDIAQSFAAA 645
                  .|::.:..|    ..:.|:..        :.|||  |........::..:|.|:.....
Zfish   551 ------AIIAQEVVYRRGPFYIPNSHF--------SPREIVERVRAGGCSPSRPYIDRAECVEEL 601

  Fly   646 ESLSVIVVRFRHLGTDVDHLIRELKQSVRKKPQPVSLPLSSGSVCKRTCCDRSNACRHR-AIEQE 709
            |||.|                                     |..:.|..:|.:....| ||:
Zfish   602 ESLVV-------------------------------------SCWRETPAERPDFSYIRTAIK-- 627

  Fly   710 PLAGRSSPSGQSDR---DLLAKDKD-----DEFVLAHARVLQEEQQLEMLDETESVSESVLSE-- 764
                ::||.|.|:.   |||::.:.     :|.|......||||::......|:.:..||.|:
Zfish   628 ----KNSPHGVSENILDDLLSRMEQYACNLEEIVSERTAELQEEKKRAEGLLTQMLPRSVASQLI 688

  Fly   765 -------EQFKC-------WEYMLEQNTQLLFDKELNTISKSFT------------KQRTVPNAI 803
                   |.:.|       .|.....:..|...:.:|.::..:|            |..|:.:|.
Zfish   689 AGKTVRAETYDCVTIYFSDIEGFTAMSASLTPMQVVNVLNDLYTYFDNIIDYHNVYKVETIGDAY 753

  Fly   804 MAATVLPERN--DFTSNLMR---TVTNKFISTSTPQLPQ 837
            |..:.||.||  |....:.|   .:.....|..:|.:|:
Zfish   754 MVVSGLPIRNGDDHAKEIARMSLAIVQGLRSFHSPHVPE 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566	16/56 (29%)
		leucine-rich repeat	111..135	CDD:275380	7/22 (32%)
		leucine-rich repeat	136..158	CDD:275380	5/21 (24%)
		leucine-rich repeat	159..183	CDD:275380	6/23 (26%)
		leucine-rich repeat	184..209	CDD:275380	5/42 (12%)
		LRR_8	205..266	CDD:290566	13/72 (18%)
		leucine-rich repeat	210..230	CDD:275380	5/29 (17%)
		leucine-rich repeat	232..255	CDD:275380	4/22 (18%)
		LRR_RI	<256..410	CDD:238064	33/186 (18%)
		leucine-rich repeat	256..276	CDD:275380	4/21 (19%)
		LRR_8	279..359	CDD:290566	16/106 (15%)
		leucine-rich repeat	280..303	CDD:275380	7/29 (24%)
		leucine-rich repeat	304..348	CDD:275380	8/63 (13%)
		leucine-rich repeat	349..372	CDD:275380	5/22 (23%)
		PP2Cc	461..655	CDD:294085	41/240 (17%)
si:dkey-37g12.1	XP_021333677.1	Periplasmic_Binding_Protein_Type_1	<59..258	CDD:324556	43/219 (20%)
		PKc_like	355..628	CDD:328722	57/349 (16%)
		HNOBA	<641..687	CDD:311573	13/45 (29%)
		CYCc	666..850	CDD:214485	25/127 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900