Protein Alignment Phlpp and LRRC2

DIOPT Version :9

• Sequence 1: NP_001260558.1
• Gene: Phlpp / 35178
• FlyBaseID: FBgn0032749
• Length: 954
• Species: Drosophila melanogaster
• Sequence 2: NP_078788.2
• Gene: LRRC2 / 79442
• HGNCID: 14676
• Length: 371
• Species: Homo sapiens
• Alignment Length: 261
• Identity: 73/261 - (27%)
• Similarity: 111/261 - (42%)
• Gaps: 64/261 - (24%)

  Fly   223 NFFAVTHARL------ETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNH---LNDSIFEPLH--- 275
            |.|..|..||      .||    .:.|:||:......:|.| ..|:|.|   |.||:.|..|
Human    66 NGFIDTSVRLLDKIERNTL----TRQSSLPKDRGKRSSAFV-FELSGEHWTELPDSLKEQTHLRE 125

  Fly   276 ----NA------------AKLRVLHLAYNRIGVLPA--ACVRNWPELEILVLSGNMLQQLPEEVA 322
                |.            ..:|:|.|..|:|..|||  .|::|..||.:   ..|.|:.:|.|:.
Human   126 WYISNTLIQIIPTYIQLFQAMRILDLPKNQISHLPAEIGCLKNLKELNV---GFNYLKSIPPELG 187

  Fly   323 TLGQLRVLRCCNNL-LLCTP-QLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGN---- 381
            ....|..|.|..|| |:..| :|:.|..:..:|:|.|....|.:..|..| ||::||:|.|
Human   188 DCENLERLDCSGNLELMELPFELSNLKQVTFVDISANKFSSVPICVLRMS-NLQWLDISSNNLTD 251

  Fly   382 LQLQVDE----QQFKVCQSQ---------SQRHWSLVDVSGNNRAALPT------TKIRQVSAQR 427
            |...:|.    |.|.:.:::         :.:..:|:.|||::...|||      |.::.||...
Human   252 LPQDIDRLEELQSFLLYKNKLTYLPYSMLNLKKLTLLVVSGDHLVELPTALCDSSTPLKFVSLMD 316

  Fly   428 N 428
            |
Human   317 N 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380
		leucine-rich repeat	184..209	CDD:275380
		LRR_8	205..266	CDD:290566	15/51 (29%)
		leucine-rich repeat	210..230	CDD:275380	3/6 (50%)
		leucine-rich repeat	232..255	CDD:275380	6/28 (21%)
		LRR_RI	<256..410	CDD:238064	54/196 (28%)
		leucine-rich repeat	256..276	CDD:275380	9/29 (31%)
		LRR_8	279..359	CDD:290566	28/83 (34%)
		leucine-rich repeat	280..303	CDD:275380	10/24 (42%)
		leucine-rich repeat	304..348	CDD:275380	14/45 (31%)
		leucine-rich repeat	349..372	CDD:275380	6/22 (27%)
		PP2Cc	461..655	CDD:294085
LRRC2	NP_078788.2	LRR 1	122..143		2/20 (10%)
		leucine-rich repeat	123..145	CDD:275380	1/21 (5%)
		LRR 2	145..166		8/20 (40%)
		leucine-rich repeat	146..168	CDD:275380	9/21 (43%)
		LRR_8	147..201	CDD:290566	19/56 (34%)
		LRR_4	167..>201	CDD:289563	10/36 (28%)
		LRR 3	168..189		7/23 (30%)
		leucine-rich repeat	169..191	CDD:275380	6/24 (25%)
		LRR 4	191..214		8/22 (36%)
		leucine-rich repeat	192..215	CDD:275380	9/22 (41%)
		LRR 5	215..235		4/19 (21%)
		leucine-rich repeat	216..238	CDD:275380	6/22 (27%)
		LRR_8	237..295	CDD:290566	15/58 (26%)
		LRR 6	238..260		8/21 (38%)
		leucine-rich repeat	239..261	CDD:275380	7/21 (33%)
		LRR 7	261..283		2/21 (10%)
		leucine-rich repeat	262..284	CDD:275380	2/21 (10%)
		LRR 8	284..305		7/20 (35%)
		leucine-rich repeat	285..308	CDD:275380	7/22 (32%)
		LRR 9	308..329		3/10 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45752
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100