DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Phlpp and LRFN3

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_078785.1 Gene:LRFN3 / 79414 HGNCID:28370 Length:628 Species:Homo sapiens


Alignment Length:592 Identity:137/592 - (23%)
Similarity:196/592 - (33%) Gaps:168/592 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   209 SLQLQSNELPSLPDNFFAVTHAR-------LETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHL 266
            ||..::.|| .|.|||.|....|       |..|::|.|.:..:......:..||..|.|.||.|
Human    56 SLDRRAAEL-RLADNFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRL 119

  Fly   267 NDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPE-LEILVLSGNMLQQLP-EEVATLGQLRV 329
            .......|.....||.|.|:.|::..|.|..:.:..| ||.|.||.|.|:||| |.:..||.:..
Human   120 TSLGEGQLRGLVNLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNT 184

  Fly   330 LRCCNNLLLCTP--QLAKLAMLKVLDLSHNHL---------DRVNLLA----------------- 366
            |...:|||...|  ..::|..|..||::.|.|         .|:.|||                 
Human   185 LGLDHNLLASVPAGAFSRLHKLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGN 249

  Fly   367 -------LVPSRNLKYLD----------LSGNLQLQVDEQQFKVCQSQSQRHWS-LVDVSGNNRA 413
                   ||..|.|...|          |.|.....|.|::| ||:.....|.| .:.|.....|
Human   250 PLHCNCELVWLRRLAREDDLEACASPPALGGRYFWAVGEEEF-VCEPPVVTHRSPPLAVPAGRPA 313

  Fly   414 AL-------PTTKIRQVSAQ--------RNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYG 463
            ||       |..::|.||.|        |.:...:|...:...| ||.|     .::...|||  
Human   314 ALRCRAVGDPEPRVRWVSPQGRLLGNSSRARAFPNGTLELLVTE-PGDG-----GIFTCIAAN-- 370

  Fly   464 GSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAAL 528
                        ..|...||.|:: :.|....|                 ||....|...|..  
Human   371 ------------AAGEATAAVELT-VGPPPPPQ-----------------LANSTSCDPPRDG-- 403

  Fly   529 FHLTRTRAPSKVRPLKSKRYVLRMASTG------------GLDAYLIRRTSQLRLTKPDVIQKDQ 581
                   .|..:.|..:.....::|.||            |..|.|::...|..:....:.|...
Human   404 -------DPDALTPPSAASASAKVADTGPPTDRGVQVTEHGATAALVQWPDQRPIPGIRMYQIQY 461

  Fly   582 IHSMPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAE 646
            ..|..|..|..:|.:....:|:   ..|.|....|.....:.::..:.|.|.|.|..|: |:...
Human   462 NSSADDILVYRMIPAESRSFLL---TDLASGRTYDLCVLAVYEDSATGLTATRPVGCAR-FSTEP 522

  Fly   647 SL-------------------------SVIVVRFRHLGTDVDHLIRELKQSVRKKPQPVSLPLSS 686
            :|                         ||:|..|        .|:...|....:.|....:|...
Human   523 ALRPCGAPHAPFLGGTMIIALGGVIVASVLVFIF--------VLLMRYKVHGGQPPGKAKIPAPV 579

  Fly   687 GSVCKRT 693
            .|||.:|
Human   580 SSVCSQT 586

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380
LRR_8 109..169 CDD:290566
leucine-rich repeat 111..135 CDD:275380
leucine-rich repeat 136..158 CDD:275380
leucine-rich repeat 159..183 CDD:275380
leucine-rich repeat 184..209 CDD:275380 137/592 (23%)
LRR_8 205..266 CDD:290566 20/63 (32%)
leucine-rich repeat 210..230 CDD:275380 8/19 (42%)
leucine-rich repeat 232..255 CDD:275380 4/22 (18%)
LRR_RI <256..410 CDD:238064 58/201 (29%)
leucine-rich repeat 256..276 CDD:275380 7/19 (37%)
LRR_8 279..359 CDD:290566 31/83 (37%)
leucine-rich repeat 280..303 CDD:275380 7/22 (32%)
leucine-rich repeat 304..348 CDD:275380 19/46 (41%)
leucine-rich repeat 349..372 CDD:275380 11/55 (20%)
PP2Cc 461..655 CDD:294085 39/230 (17%)
LRFN3NP_078785.1 LRR_8 59..119 CDD:290566 18/60 (30%)
LRR 1 60..83 8/23 (35%)
LRR_RI <63..168 CDD:238064 34/105 (32%)
leucine-rich repeat 63..84 CDD:275380 8/21 (38%)
LRR 2 84..105 4/20 (20%)
leucine-rich repeat 85..108 CDD:275380 4/22 (18%)
LRR 3 108..129 8/20 (40%)
leucine-rich repeat 109..132 CDD:275380 7/22 (32%)
LRR 4 132..153 7/20 (35%)
leucine-rich repeat 133..157 CDD:275380 7/23 (30%)
LRR_8 157..216 CDD:290566 23/58 (40%)
LRR 5 157..178 11/20 (55%)
leucine-rich repeat 158..181 CDD:275380 12/22 (55%)
LRR 6 181..202 5/20 (25%)
leucine-rich repeat 182..205 CDD:275380 6/22 (27%)
LRR 7 205..226 5/20 (25%)
leucine-rich repeat 206..230 CDD:275380 6/23 (26%)
leucine-rich repeat 242..253 CDD:275378 0/10 (0%)
TPKR_C2 249..>281 CDD:301599 6/31 (19%)
IG_like 302..383 CDD:214653 23/101 (23%)
Ig 310..383 CDD:299845 21/93 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 382..430 11/74 (15%)
fn3 424..502 CDD:278470 14/80 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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