DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and Gucy2d

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_077356.1	Gene:	Gucy2d / 79222	RGDID:	620438	Length:	1108	Species:	Rattus norvegicus

Alignment Length:	593	Identity:	115/593 - (19%)
Similarity:	201/593 - (33%)	Gaps:	193/593 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   354 LSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTT 418
            |:|....|:..:.:|...|        .:.|.:::..|...|..|.|  .:...|.::.|...|:
  Rat   486 LAHYLRHRLLHMQMVSGPN--------KIILTLEDVTFLHPQGGSSR--KVAQGSRSSLATRSTS 540

  Fly   419 KIRQVSAQRNQNKT----SGPWTMGFAETPGS-----GDCRKLSVYQLRAANYGGSDEALY-GMF 473
            .||.|.:|..::..    .|.| :...:.||.     ....|::..:||...:  .:.||| |:|
  Rat   541 DIRSVPSQPQESTNIGLYEGDW-VWLKKFPGEHHMAIRPATKMAFSKLRELRH--ENVALYLGLF 602

  Fly   474 -------EALEGRGRAAQEMSHL----VPDLMKQ-----EQMVKDSAVRDYMKFTLLAAQQQCGS 522
                   .|..|.|..|....|.    :.||:.|     :.|.|.|.:.|.:|           .
  Rat   603 LAGTADSPATPGEGILAVVSEHCARGSLHDLLAQRDIKLDWMFKSSLLLDLIK-----------G 656

  Fly   523 VRSAALFHLTRTRAPSKVRPLKSK------RYVLRMASTGG---LDAYLIRRTSQLRLTKPDVIQ 578
            :|  .|.|    |..:..| |||:      |:||::...|.   |:|..:
  Rat   657 MR--YLHH----RGVAHGR-LKSRNCVVDGRFVLKVTDHGHGRLLEAQRV--------------- 699

  Fly   579 KDQIHSMPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFA 643
                  :|:|.      |.:|        |||:..::   .|:...|....||.    |:   |:
  Rat   700 ------LPEPP------SAED--------QLWTAPEL---LRDPALERRGTLAG----DV---FS 734

  Fly   644 AAESLSVIVVR---FRHLGTDVDHLIRELKQSVRKKPQPVSLPLSSGSVCKRTCCDRSNAC--RH 703
            ....:..:|.|   :..|....:.:|:.:     :.|.|:..||.|.......|......|  .|
  Rat   735 LGIIMQEVVCRSTPYAMLELTPEEVIQRV-----RSPPPLCRPLVSMDQAPMECIQLMAQCWAEH 794

  Fly   704 RAIEQEPLAGRSSPSGQSDRDL---LAKDKDDEFVLAHARVLQE---------EQQLEMLDETES 756
            ..:.         ||.....||   :.|.:....:.:..|:|::         .::.|.|::.:.
  Rat   795 PELR---------PSMDLTFDLFKGINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELEQEKQ 850

  Fly   757 VSESVLSE-------EQFKCW-----EYMLE---------------------------QNTQLLF 782
            .::.:|::       |..|..     ||..|                           .:...||
  Rat   851 KTDRLLTQMLPPSVAEALKMGTSVEPEYFEEVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLF 915

  Fly   783 DKELNTISKSFTKQRTVPNAIMAATVLPERN---------DFTSNLMRTVTNKFISTSTPQLPQP 838
            |..:.  |....|..|:.:|.|.|:.||:||         :.:.:::..| ..|.....|::|..
  Rat   916 DAIIG--SHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAV-GSFRMRHMPEVPVR 977

  Fly   839 ITTSVPLG 846
            |...:..|
  Rat   978 IRIGLHSG 985

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380
		leucine-rich repeat	184..209	CDD:275380
		LRR_8	205..266	CDD:290566
		leucine-rich repeat	210..230	CDD:275380
		leucine-rich repeat	232..255	CDD:275380
		LRR_RI	<256..410	CDD:238064	11/55 (20%)
		leucine-rich repeat	256..276	CDD:275380
		LRR_8	279..359	CDD:290566	2/4 (50%)
		leucine-rich repeat	280..303	CDD:275380
		leucine-rich repeat	304..348	CDD:275380
		leucine-rich repeat	349..372	CDD:275380	4/17 (24%)
		PP2Cc	461..655	CDD:294085	47/222 (21%)
Gucy2d	NP_077356.1	PBP1_sensory_GC_DEF-like	58..434	CDD:380594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	520..552		9/33 (27%)
		PK_GC-2D	540..814	CDD:270945	72/353 (20%)
		HNOBA	<823..868	CDD:400168	6/44 (14%)
		CYCc	848..1039	CDD:214485	25/141 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1069..1108
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900