DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and Lrrc2

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:XP_006512427.1 Gene:Lrrc2 / 74249 MGIID:1921499 Length:379 Species:Mus musculus


Alignment Length:300 Identity:77/300 - (25%)
Similarity:126/300 - (42%) Gaps:57/300 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   140 DISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGF 204
            ::|...:.|||                :.|.....|...|..:.|:.:...|.:|         |
Mouse   112 ELSGTQWKELP----------------DSLKEQTHLKEWYIHSTLIQIIPTYIEL---------F 151

  Fly   205 SSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGN-HLND 268
            .:::.|.|..|::..||.....:.:  |:.||||.|.|.::|. |..:...|..|..:|| .|.|
Mouse   152 QAMKILDLPKNQITCLPAEIGRLKN--LKELNVSFNHLKSIPP-ELGDCEHLERLDCSGNLDLMD 213

  Fly   269 SIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCC 333
            ..|| |.|..::..:.::.|:...:| .||.....|:.|.:|.|.|..||:::..|.:|:.....
Mouse   214 LPFE-LSNLKQVTFVDISANKFSSVP-ICVLRMCRLQWLDISSNNLSDLPQDIDRLEELQGFLLY 276

  Fly   334 NNLLLCTPQ-LAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQS- 396
            .|.|...|| :..|..|.:|.:|.:||..|.......|..||::.|..|   .:|:..   ||. 
Mouse   277 KNKLTYLPQAMLNLKKLTLLVVSGDHLVEVPTALCDASTPLKFVSLVDN---PIDKTG---CQDT 335

  Fly   397 ----QSQR---HWS-------LVDVSGNNRAALP--TTKI 420
                :|:|   |:.       :.|:  ..|.|:|  |||:
Mouse   336 EDTVESERDRQHFDKEFMKAYIEDL--KEREAVPSYTTKV 373

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380
LRR_8 109..169 CDD:290566 4/28 (14%)
leucine-rich repeat 111..135 CDD:275380
leucine-rich repeat 136..158 CDD:275380 4/17 (24%)
leucine-rich repeat 159..183 CDD:275380 3/23 (13%)
leucine-rich repeat 184..209 CDD:275380 4/24 (17%)
LRR_8 205..266 CDD:290566 18/61 (30%)
leucine-rich repeat 210..230 CDD:275380 5/19 (26%)
leucine-rich repeat 232..255 CDD:275380 9/22 (41%)
LRR_RI <256..410 CDD:238064 46/170 (27%)
leucine-rich repeat 256..276 CDD:275380 9/20 (45%)
LRR_8 279..359 CDD:290566 21/80 (26%)
leucine-rich repeat 280..303 CDD:275380 4/22 (18%)
leucine-rich repeat 304..348 CDD:275380 14/44 (32%)
leucine-rich repeat 349..372 CDD:275380 7/22 (32%)
PP2Cc 461..655 CDD:294085
Lrrc2XP_006512427.1 LRR <107..376 CDD:227223 77/299 (26%)
leucine-rich repeat 131..153 CDD:275380 6/30 (20%)
leucine-rich repeat 154..176 CDD:275380 5/21 (24%)
leucine-rich repeat 177..199 CDD:275380 9/22 (41%)
leucine-rich repeat 200..223 CDD:275380 10/23 (43%)
leucine-rich repeat 224..245 CDD:275380 4/21 (19%)
leucine-rich repeat 247..269 CDD:275380 8/21 (38%)
leucine-rich repeat 270..292 CDD:275380 6/21 (29%)
leucine-rich repeat 293..316 CDD:275380 7/22 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45752
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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