DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and Gucy2g

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001074545.1	Gene:	Gucy2g / 73707	MGIID:	106025	Length:	1100	Species:	Mus musculus

Alignment Length:	388	Identity:	72/388 - (18%)
Similarity:	123/388 - (31%)	Gaps:	132/388 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   448 DCRKLSVYQLRAANYG------GSDEALYGMFEALEGRGRAAQEMSHLVPDLMK-QEQMVKDSAV 505
            :|...|..||:.:.:|      ||....|.. ||.:     ..|:....|:|:: :|.....:..
Mouse   685 NCLVDSHMQLKLSGFGLWEFKHGSTWRSYNQ-EATD-----HSELYWTAPELLRLRESPCSGTPQ 743

  Fly   506 RDYMKFTLLAA----QQQCG------SVRSAALFHLTRTRAPSKVRPLKSKRYVLRMASTGGLDA 560
            .|...|.:|..    ||..|      :.....:..:...|||..:||     .:|.....|.:.|
Mouse   744 GDVYSFAILLRDLIHQQAHGPFEDLEAAPEEIISRIKDPRAPVPLRP-----SLLEDKGDGRIVA 803

  Fly   561 YLIR----RTSQLRLTKPDVIQKDQIHSMPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAARE 621
             |:|    .:.:||...|. |:|....:.|..||                    |::|
Mouse   804 -LVRECWDESPELRPIFPS-IKKTLREASPRGHV--------------------SILD------- 839

  Fly   622 IRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFRHLGTDVDHLIRELKQSVRKKPQPVSLPLSS 686
                        .::...:::|            .||...|:...|||....||..:.:|..|.|
Mouse   840 ------------SMMGKLETYA------------NHLEEVVEERTRELVAEKRKVEKLLSTMLPS 880

  Fly   687 GSVCKRTCCDRSNACRHRAIEQEPLAGRS-SPSGQSDRDLLAKDKDDEFVLAHARVLQEEQQLEM 750
                              .:.::.:||:| .|.......:...|     ::...::......|::
Mouse   881 ------------------FVGEQLIAGKSVEPEHFESVTIFFSD-----IVGFTKLCSLSSPLQV 922

  Fly   751 LDETESVSESVLSEEQFKCWEYMLEQNTQLLFDKELNTISKSFTKQRTVPNAIMAATVLPERN 813
            :                     .|..:...|||..:.  |....|..|:.:|.|.|:.||.||
Mouse   923 V---------------------KLLNDLYSLFDHTIQ--SHDVYKVETIGDAYMVASGLPIRN 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380
		leucine-rich repeat	184..209	CDD:275380
		LRR_8	205..266	CDD:290566
		leucine-rich repeat	210..230	CDD:275380
		leucine-rich repeat	232..255	CDD:275380
		LRR_RI	<256..410	CDD:238064
		leucine-rich repeat	256..276	CDD:275380
		LRR_8	279..359	CDD:290566
		leucine-rich repeat	280..303	CDD:275380
		leucine-rich repeat	304..348	CDD:275380
		leucine-rich repeat	349..372	CDD:275380
		PP2Cc	461..655	CDD:294085	37/214 (17%)
Gucy2g	NP_001074545.1	PBP1_GC_G-like	47..436	CDD:380595
		PK_GC	555..829	CDD:270894	35/156 (22%)
		CYCc	865..1055	CDD:214485	25/144 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900