DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and TPBG

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001159864.1	Gene:	TPBG / 7162	HGNCID:	12004	Length:	420	Species:	Homo sapiens

Alignment Length:	323	Identity:	80/323 - (24%)
Similarity:	115/323 - (35%)	Gaps:	92/323 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 GACASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELP 218
            |.|:...|......||..:|::|..:     ||.....:............:|..|.|      |
Human     3 GGCSRGPAAGDGRLRLARLALVLLGW-----VSSSSPTSSASSFSSSAPFLASAVSAQ------P 56

  Fly   219 SLPDNFFAVTHARLETLNVSC-NKLST-----LPRYEQNNHAALVNLSLAGNH---LNDSIFEPL 274
            .|||...|:.........|.| |:..|     ||.|.:       ||.|.||.   |....|...
Human    57 PLPDQCPALCECSEAARTVKCVNRNLTEVPTDLPAYVR-------NLFLTGNQLAVLPAGAFARR 114

  Fly   275 HNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQL---------------------- 317
            ...|:|..|:|:.:|:..:.|....:.|.|..|.||.|.|..|
Human   115 PPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELI 179

  Fly   318 ------PEE-----------VATL--GQ----LRVLRCCNNLLLCTPQ--LAKLAMLKVLDLSHN 357
                  ||:           ||.|  |:    ||.|...:|..|..|:  ||:|..|:.||||:|
Human   180 LNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNN 244

  Fly   358 HLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKI 420
            .|..   |..|..|||.:|:     .|.:::...||.     .:.:|.::.|     ||..::
Human   245 SLVS---LTYVSFRNLTHLE-----SLHLEDNALKVL-----HNGTLAELQG-----LPHIRV 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566	3/14 (21%)
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380	2/3 (67%)
		leucine-rich repeat	159..183	CDD:275380	5/23 (22%)
		leucine-rich repeat	184..209	CDD:275380	3/24 (13%)
		LRR_8	205..266	CDD:290566	20/69 (29%)
		leucine-rich repeat	210..230	CDD:275380	6/19 (32%)
		leucine-rich repeat	232..255	CDD:275380	7/28 (25%)
		LRR_RI	<256..410	CDD:238064	53/203 (26%)
		leucine-rich repeat	256..276	CDD:275380	7/22 (32%)
		LRR_8	279..359	CDD:290566	34/126 (27%)
		leucine-rich repeat	280..303	CDD:275380	5/22 (23%)
		leucine-rich repeat	304..348	CDD:275380	22/90 (24%)
		leucine-rich repeat	349..372	CDD:275380	9/22 (41%)
		PP2Cc	461..655	CDD:294085
TPBG	NP_001159864.1	LRRNT	61..95	CDD:214470	8/40 (20%)
		leucine-rich repeat	73..95	CDD:275380	7/28 (25%)
		LRR 1. /evidence=ECO:0000269\|PubMed:24582434	92..113		8/27 (30%)
		LRR_8	93..154	CDD:338972	19/67 (28%)
		leucine-rich repeat	96..119	CDD:275380	6/22 (27%)
		LRR 2. /evidence=ECO:0000269\|PubMed:24582434	116..139		6/22 (27%)
		leucine-rich repeat	120..143	CDD:275380	5/22 (23%)
		LRR 3. /evidence=ECO:0000269\|PubMed:24582434	141..163		8/21 (38%)
		leucine-rich repeat	144..167	CDD:275380	7/22 (32%)
		LRR 4. /evidence=ECO:0000269\|PubMed:24582434	172..204		4/31 (13%)
		leucine-rich repeat	175..211	CDD:275380	6/35 (17%)
		LRR 5. /evidence=ECO:0000269\|PubMed:24582434	209..232		7/22 (32%)
		LRR_8	211..270	CDD:338972	23/66 (35%)
		leucine-rich repeat	212..235	CDD:275380	9/22 (41%)
		LRR 6. /evidence=ECO:0000269\|PubMed:24582434	233..255		10/24 (42%)
		leucine-rich repeat	236..259	CDD:275380	12/25 (48%)
		LRR 7. /evidence=ECO:0000269\|PubMed:24582434	256..275		6/28 (21%)
		leucine-rich repeat	260..283	CDD:275380	5/32 (16%)
		LRRCT	294..345	CDD:214507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910