DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and Lrriq4

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_011248011.1	Gene:	Lrriq4 / 68307	MGIID:	1915557	Length:	599	Species:	Mus musculus

Alignment Length:	565	Identity:	127/565 - (22%)
Similarity:	207/565 - (36%)	Gaps:	172/565 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 VSASHSGPHPLPVEVTAAEE--------EQAATFGQTSPQKLSLKGSQLGGSIL------IGNYN 68
            :..|:.|...:|.|:.|.:|        .|.|...|...|..:.|...|..:.|      :|..:
Mouse    69 IDGSNQGLKTIPSEILALKELEEVHLENNQIAEIPQGIQQLQNTKVLYLHNNSLQDLCPELGALS 133

  Fly    69 YLTQLEVCENEMEVLDLSSLAQLETLK----------------C-----------SRN---KLME 103
            .|..|::..|.:.:..|..:::|.||:                |           |.|   .|.|
Mouse   134 SLESLDLSGNPLVISSLHVVSRLRTLRELRLYRTGLTEIPTGICKSLHHLELFGLSENFLESLPE 198

  Fly   104 LIINGT-----------------------NLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNN 145
            .|:|.|                       ||:.:..|.|.|.:|.....|.|  :||:..::.|:
Mouse   199 EIVNQTKLREIYLKQNHFEVFPCDLCVLYNLEVIDLDENKLKSIPGDIGHLV--RLQKFYVASNH 261

  Fly   146 FSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRSL 210
            ...||..:..|:.|:.::.:||.::::...|.  .:|||..:.|:.|.|:::.:....:.|:..|
Mouse   262 LMSLPESLSQCSKLSVLDLTHNSIHSLPSSLE--LLTELTEVGLSGNRLEKVPRLLCSWVSLHLL 324

  Fly   211 QLQSNELPSLPDNFFAVTHAR---------------------LETLNVSCNKLSTLPRYEQNNHA 254
            .|::..|..|.|:|..:.:.|                     ||.|.:..||:..||    .:.:
Mouse   325 YLRNTSLHGLRDSFKRLINLRFLDLSQNHIEHFPVQICALKNLEILALDDNKVRQLP----PSIS 385

  Fly   255 ALVNLSLAGNHLND----------------------------SIFEPLHNAAKLRVLHLAYNRIG 291
            .|.||.:.|...||                            |:.|.:.....|:.|::..||:.
Mouse   386 LLSNLKILGLTGNDLLSFPEEIFSLISLEKLYIGQDQGSKLSSLPENIKRLMNLKELYIENNRLE 450

  Fly   292 VLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQ-LAKLAMLKVLDLS 355
            .|||: :...|.||:|....|:|:|||:.:.....||.|...:|||.|.|: |..|..||||.|.
Mouse   451 QLPAS-LGLMPNLEVLDCRHNLLKQLPDAICRTRNLRELLLEDNLLCCLPENLDHLVNLKVLTLM 514

  Fly   356 HNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKI 420
            :|.:                          ||...: ||...::..|.          .|...:|
Mouse   515 NNPM--------------------------VDPPIY-VCNQGNEAIWK----------HLKENRI 542

  Fly   421 RQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGS 465
            |::.|     .|...|..|.....|.|...:|    |:|...|.|
Mouse   543 RKMMA-----TTIQAWWRGIMVRKGYGSYEEL----LKARKKGKS 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	11/71 (15%)
		LRR_8	109..169	CDD:290566	18/82 (22%)
		leucine-rich repeat	111..135	CDD:275380	7/23 (30%)
		leucine-rich repeat	136..158	CDD:275380	6/21 (29%)
		leucine-rich repeat	159..183	CDD:275380	4/23 (17%)
		leucine-rich repeat	184..209	CDD:275380	5/24 (21%)
		LRR_8	205..266	CDD:290566	19/81 (23%)
		leucine-rich repeat	210..230	CDD:275380	6/19 (32%)
		leucine-rich repeat	232..255	CDD:275380	7/22 (32%)
		LRR_RI	<256..410	CDD:238064	45/182 (25%)
		leucine-rich repeat	256..276	CDD:275380	8/47 (17%)
		LRR_8	279..359	CDD:290566	32/80 (40%)
		leucine-rich repeat	280..303	CDD:275380	7/22 (32%)
		leucine-rich repeat	304..348	CDD:275380	18/44 (41%)
		leucine-rich repeat	349..372	CDD:275380	6/22 (27%)
		PP2Cc	461..655	CDD:294085	2/5 (40%)
Lrriq4	XP_011248011.1	LRR_RI	48..309	CDD:393385	52/243 (21%)
		leucine-rich repeat	89..111	CDD:275380	4/21 (19%)
		leucine-rich repeat	112..135	CDD:275380	4/22 (18%)
		leucine-rich repeat	183..205	CDD:275380	6/21 (29%)
		leucine-rich repeat	206..228	CDD:275380	0/21 (0%)
		LRR	228..521	CDD:227223	80/327 (24%)
		leucine-rich repeat	229..251	CDD:275380	7/23 (30%)
		leucine-rich repeat	252..274	CDD:275380	6/21 (29%)
		leucine-rich repeat	275..297	CDD:275380	4/23 (17%)
		leucine-rich repeat	298..320	CDD:275380	4/21 (19%)
		leucine-rich repeat	321..343	CDD:275380	6/21 (29%)
		leucine-rich repeat	344..366	CDD:275380	1/21 (5%)
		leucine-rich repeat	367..389	CDD:275380	8/25 (32%)
		leucine-rich repeat	390..438	CDD:275380	6/47 (13%)
		leucine-rich repeat	413..436	CDD:275380	2/22 (9%)
		leucine-rich repeat	439..461	CDD:275380	7/22 (32%)
		leucine-rich repeat	462..484	CDD:275380	8/21 (38%)
		leucine-rich repeat	485..507	CDD:275380	10/21 (48%)
		IQ	543..563	CDD:197470	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910