DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and Lrrc40

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_077156.2 Gene:Lrrc40 / 67144 MGIID:1914394 Length:602 Species:Mus musculus


Alignment Length:442 Identity:116/442 - (26%)
Similarity:181/442 - (40%) Gaps:85/442 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 GQTSPQKLSLKGSQLGGSILIGNYN--------YLTQLEVCENEMEVLDLSSLAQLETLKCSRNK 100
            |.:.||.| ||.::..|.:.:...|        :...:::.|...:.|..||..:.    ..:..
Mouse    24 GPSVPQGL-LKAARSSGQLNLAGRNLGEVPQCVWRINVDIPEEANQNLSFSSTERW----WDQTD 83

  Fly   101 LMELIINGTNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINAS 165
            |.:|||:...||:|..|...|..::.            :||..|..:.||:.:....:|..:|.|
Mouse    84 LTKLIISSNKLQSLSDDLRLLPALTV------------LDIHDNQLTSLPSAIRELDNLQKLNVS 136

  Fly   166 HNRLN---NVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGF---SSIRSLQLQSNELPSLPDNF 224
            ||:|.   .....|:|.|     :|.|.:|:|..:   ||||   |.:..|.|.||.|.::|.:|
Mouse   137 HNKLKILPEEITSLKNLR-----TLHLQHNELTCI---PEGFEHLSCLEDLDLSSNRLATVPADF 193

  Fly   225 FAVTHARLETLNVSCNKLSTLP----RYEQNNH------------------AALVNLSLAGNHLN 267
            ..:  :.|..||:|.|:|..||    |.::..|                  .:|..|.|..|.|.
Mouse   194 ALL--SSLLRLNLSSNQLKNLPAEISRMKRLKHLDCDANLLETVPPDVGSMESLELLYLRRNKLR 256

  Fly   268 DSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRC 332
              :.....:..:|:.||||.|:|..|.|..:::...:.:|.|.||.|:.:|||:|.|..|..|..
Mouse   257 --VLPEFPSCRQLKELHLAENQIEKLGAEHLQHLQAILVLDLRGNKLRSVPEEMALLQSLERLDL 319

  Fly   333 CNNLLLCTPQLAKLAMLKVLDLSHNHLD--RVNLLALVPSRNLKYL-----DLSGNLQLQVDEQQ 390
            .||.:...|.......||.|.|..|.|.  |..::|......||||     |...|....|.|..
Mouse   320 SNNDISSLPCSLGNLHLKFLALEGNPLRTIRREIIAKGTQEVLKYLRSKIKDDRTNQNDSVPETA 384

  Fly   391 FKV-CQSQSQRH----WSLVDVSGNNRAALP--------TTKIRQVSAQRNQ 429
            ..: .:::...|    ..|:|.|......:|        ||.|..::..:||
Mouse   385 MTLPSEARVNIHAIATLKLLDYSDKQATLIPDDLFDATKTTLITSINFSKNQ 436

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380 4/18 (22%)
LRR_8 109..169 CDD:290566 15/59 (25%)
leucine-rich repeat 111..135 CDD:275380 5/23 (22%)
leucine-rich repeat 136..158 CDD:275380 5/21 (24%)
leucine-rich repeat 159..183 CDD:275380 9/26 (35%)
leucine-rich repeat 184..209 CDD:275380 9/27 (33%)
LRR_8 205..266 CDD:290566 22/82 (27%)
leucine-rich repeat 210..230 CDD:275380 7/19 (37%)
leucine-rich repeat 232..255 CDD:275380 10/44 (23%)
LRR_RI <256..410 CDD:238064 49/165 (30%)
leucine-rich repeat 256..276 CDD:275380 5/19 (26%)
LRR_8 279..359 CDD:290566 29/79 (37%)
leucine-rich repeat 280..303 CDD:275380 9/22 (41%)
leucine-rich repeat 304..348 CDD:275380 15/43 (35%)
leucine-rich repeat 349..372 CDD:275380 8/24 (33%)
PP2Cc 461..655 CDD:294085
Lrrc40NP_077156.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26 1/1 (100%)
LRR 1 35..58 2/22 (9%)
leucine-rich repeat 38..83 CDD:275380 6/48 (13%)
LRR 2 81..103 8/21 (38%)
LRR_8 84..140 CDD:290566 19/67 (28%)
leucine-rich repeat 84..106 CDD:275380 9/21 (43%)
LRR_RI 101..368 CDD:238064 82/290 (28%)
LRR 3 104..126 6/33 (18%)
leucine-rich repeat 107..129 CDD:275380 5/33 (15%)
LRR 4 127..149 6/21 (29%)
LRR_8 129..186 CDD:290566 22/64 (34%)
leucine-rich repeat 130..152 CDD:275380 7/21 (33%)
LRR 5 150..172 11/29 (38%)
leucine-rich repeat 153..175 CDD:275380 9/29 (31%)
LRR 6 174..195 8/20 (40%)
leucine-rich repeat 176..221 CDD:275380 16/46 (35%)
LRR 7 196..219 8/24 (33%)
LRR_8 220..277 CDD:290566 12/58 (21%)
LRR 8 221..241 1/19 (5%)
leucine-rich repeat 222..244 CDD:275380 1/21 (5%)
LRR 9 242..266 5/25 (20%)
leucine-rich repeat 245..266 CDD:275380 5/22 (23%)
LRR_RI 248..505 CDD:238064 54/191 (28%)
LRR_8 265..324 CDD:290566 23/58 (40%)
leucine-rich repeat 267..290 CDD:275380 9/22 (41%)
LRR 10 268..287 8/18 (44%)
LRR 11 288..310 8/21 (38%)
leucine-rich repeat 291..313 CDD:275380 10/21 (48%)
LRR 12 311..334 6/22 (27%)
LRR 13 336..356 7/19 (37%)
leucine-rich repeat 365..473 CDD:275380 15/72 (21%)
LRR 14 398..421 4/22 (18%)
LRR 15 424..447 5/13 (38%)
LRR 16 449..470
LRR_8 454..507 CDD:290566
LRR 17 471..494
LRR 18 496..517
leucine-rich repeat 497..519 CDD:275380
LRR_8 518..577 CDD:290566
LRR 19 519..540
leucine-rich repeat 520..543 CDD:275380
LRR 20 541..564
LRR 21 566..587
leucine-rich repeat 567..578 CDD:275378
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR45752
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.100

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