DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Phlpp and Gucy1a2

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_076446.1 Gene:Gucy1a2 / 66012 RGDID:621655 Length:730 Species:Rattus norvegicus


Alignment Length:537 Identity:106/537 - (19%)
Similarity:169/537 - (31%) Gaps:166/537 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   142 SHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSS 206
            :..||..:.|   .|:|  |.:::...:.:|:.:|   |.|..| |.|.:.:::  ::|.|.|..
  Rat   124 AEKNFHNISN---RCSS--ADHSNKEEIEDVSGIL---RCTANV-LGLKFQEIQ--ERFGEEFFK 177

  Fly   207 I------RSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNH 265
            |      |.|:...:.|    .:||....|.||.:..|..|.:||      ...:.:...|....
  Rat   178 ICFDENERVLRAVGSTL----QDFFNGFDALLEHIRTSFGKQATL------ESPSFLCKELPEGT 232

  Fly   266 LNDSIFEPLH----------NAAKLRVLHL--------------------AYNRIGVLPAAC--- 297
            |....|.|.|          .||..|:.||                    .|:.:..|...|   
  Rat   233 LKLHYFHPHHTVGFAMLGMIKAAGKRIYHLNVEVEQIENEKFCSDGSTPSNYSCLTFLIKECETT 297

  Fly   298 --VRNWP--------ELEI------------LVLSGNM-LQQLPEEVATLGQLRVLRCCNNLLLC 339
              .:|.|        :|.|            |:...|| :.||.|     |..:.|||.|:.:|.
  Rat   298 QITKNIPQGTSQIPTDLRISINTFCRTFPFHLMFDPNMVVLQLGE-----GLRKQLRCDNHKVLK 357

  Fly   340 TPQLAKLAMLKVLDLSHNHLDRVNLLALVP------------SRNLKYLDLSGNLQLQVDEQQF- 391
            .....::...||    :...|||.|....|            ....|.:::.|.: :.|.|... 
  Rat   358 FEDCFEIVSPKV----NATFDRVLLRLSTPFVIRTKPEASGTDNEDKVMEIKGQM-IHVPESNAI 417

  Fly   392 ----KVCQSQSQR------HWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGS 446
                ..|..:...      |.|.:.:....|..:...:  |..||....|..........:|..:
  Rat   418 LFLGSPCVDKLDELIGRGLHLSDIPIHDATRDVILVGE--QAKAQDGLKKRMDKLKATLEKTHQA 480

  Fly   447 GDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVK----DSAV-- 505
            .:..|.....|           ||.:|.     |..||:        :.|.|.|:    |...  
  Rat   481 LEEEKKKTVDL-----------LYSIFP-----GDVAQQ--------LWQRQQVQARKFDDVTML 521

  Fly   506 -RDYMKFTLLAAQQQCGSVRSAALFHLTRTRAPSKVRPLKSKRYVLRMASTGGLDAYLIRRTSQL 569
             .|.:.||.:.|  ||               .|.:|..:.::.|.......|.||.|.:......
  Rat   522 FSDIVGFTAICA--QC---------------TPMQVISMLNELYTRFDHQCGFLDIYKVETIGDA 569

  Fly   570 RLTKPDVIQKDQIHSMP 586
            ......:.:|...|:.|
  Rat   570 YCVASGLHRKSLCHAKP 586

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380
LRR_8 109..169 CDD:290566 6/26 (23%)
leucine-rich repeat 111..135 CDD:275380
leucine-rich repeat 136..158 CDD:275380 4/15 (27%)
leucine-rich repeat 159..183 CDD:275380 4/23 (17%)
leucine-rich repeat 184..209 CDD:275380 7/30 (23%)
LRR_8 205..266 CDD:290566 14/66 (21%)
leucine-rich repeat 210..230 CDD:275380 4/19 (21%)
leucine-rich repeat 232..255 CDD:275380 6/22 (27%)
LRR_RI <256..410 CDD:238064 43/232 (19%)
leucine-rich repeat 256..276 CDD:275380 5/29 (17%)
LRR_8 279..359 CDD:290566 24/125 (19%)
leucine-rich repeat 280..303 CDD:275380 8/55 (15%)
leucine-rich repeat 304..348 CDD:275380 14/56 (25%)
leucine-rich repeat 349..372 CDD:275380 7/34 (21%)
PP2Cc 461..655 CDD:294085 26/133 (20%)
Gucy1a2NP_076446.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..53
HNOB <157..268 CDD:285002 29/123 (24%)
HNOBA 314..501 CDD:285003 40/214 (19%)
CYCc 483..672 CDD:214485 28/145 (19%)
Guanylate_cyc 512..696 CDD:278633 17/92 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.