DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and Adcy5

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_072122.2	Gene:	Adcy5 / 64532	RGDID:	71014	Length:	1262	Species:	Rattus norvegicus

Alignment Length:	338	Identity:	59/338 - (17%)
Similarity:	116/338 - (34%)	Gaps:	96/338 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 VLSGNMLQQL---------PEEVATLGQL----RVLRCCNNLLLCTPQLAKLAMLKVLDLSHN-- 357
            ||||.:|..|         .::...|.||    .:..|.|.:.:||...|:::..:....:..
  Rat   352 VLSGVLLSALHLAISLHTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECI 416

  Fly   358 ----HLDRVN------LLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLV--DVSGN 410
                |..|.|      ||:::| |::. :::..::..:.::..|.....|...:.|::  |:.|.
  Rat   417 QARLHSQRENQQQERLLLSVLP-RHVA-MEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGF 479

  Fly   411 NRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEA 475
                  |:...|.:|| ....|.......|.:......|.::.:       .|.....:.|:.||
  Rat   480 ------TSLASQCTAQ-ELVMTLNELFARFDKLAAENHCLRIKI-------LGDCYYCVSGLPEA 530

  Fly   476 LEGRGRAAQEMSHLVPDLMKQEQMVKD-SAVRDYMKFTLLAAQQQCGSV---------------- 523
            .........||.   .|:::...:|:: :.|...|:..:.:.:..||.:
  Rat   531 RADHAHCCVEMG---MDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTL 592

  Fly   524 -------RSAALFHLTRT-----RAPSKVRPLKSKRYVLRMASTGG----------LDAYLIRRT 566
                   ..|...|:|:.     ....:|.|           ..||          ::.:||.|.
  Rat   593 ANHMEAGGKAGRIHITKATLNYLNGDYEVEP-----------GCGGERNAYLKEHSIETFLILRC 646

  Fly   567 SQLRLTKPDVIQK 579
            :|.|..:..:|.|
  Rat   647 TQKRKEEKAMIAK 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380
		leucine-rich repeat	184..209	CDD:275380
		LRR_8	205..266	CDD:290566
		leucine-rich repeat	210..230	CDD:275380
		leucine-rich repeat	232..255	CDD:275380
		LRR_RI	<256..410	CDD:238064	25/128 (20%)
		leucine-rich repeat	256..276	CDD:275380
		LRR_8	279..359	CDD:290566	14/69 (20%)
		leucine-rich repeat	280..303	CDD:275380
		leucine-rich repeat	304..348	CDD:275380	14/52 (27%)
		leucine-rich repeat	349..372	CDD:275380	6/34 (18%)
		PP2Cc	461..655	CDD:294085	26/158 (16%)
Adcy5	NP_072122.2	AC_N	1..459	CDD:318454	21/108 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..196
		Guanylate_cyc	461..634	CDD:306677	30/200 (15%)
		DUF1053	669..761	CDD:399378
		Guanylate_cyc	1063..1257	CDD:306677
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900