DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and Adcy3

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_570135.2 Gene:Adcy3 / 64508 RGDID:71009 Length:1144 Species:Rattus norvegicus


Alignment Length:559 Identity:114/559 - (20%)
Similarity:194/559 - (34%) Gaps:201/559 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   296 ACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLD 360
            :||     :..|||...:.||..:|:..:..||.:.....|.||.        :.|..:|:...|
  Rat   197 SCV-----VHTLVLGVTVAQQQQDELEGMQLLREILANVFLYLCA--------IIVGIMSYYMAD 248

  Fly   361 RVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWS---LVDVSGNNRAALPTTKIRQ 422
            |.:..|.:.:|  :.|::..||:.| .:||..:..|...:|.:   |.|             :::
  Rat   249 RKHRKAFLEAR--QSLEVKMNLEEQ-SQQQENLMLSILPKHVADEMLKD-------------MKK 297

  Fly   423 VSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMS 487
            ..:|::|.:.:                   ::|..|..|.......:.| |..|.. ..:|||:.
  Rat   298 DESQKDQQQFN-------------------TMYMYRHENVSILFADIVG-FTQLSS-ACSAQELV 341

  Fly   488 HLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAALFHLTRTRAPSKVRPLKSKRYVLRM 552
            .|:.:|              :.:|..|||:           :|..|      ::.|....|.:  
  Rat   342 KLLNEL--------------FARFDKLAAK-----------YHQLR------IKILGDCYYCI-- 373

  Fly   553 ASTGGLDAY--------------LIRRTSQLR-LTKPDVIQKDQIHSMPDPHVLELILSNDDEYL 602
               .||..|              ::...|.:| .||..|..:..:|:       ..:|..     
  Rat   374 ---CGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHT-------GTVLGG----- 423

  Fly   603 VVGNAQ----LWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFRHLGTDVD 663
            |:|..:    :||. |:..|    .|.|...:..:  |.|:||     ::..:...|     ||:
  Rat   424 VLGQKRWQYDVWST-DVTVA----NKMEAGGIPGR--VHISQS-----TMDCLKGEF-----DVE 471

  Fly   664 ------------------HLIRELKQSVRKKPQ------------PVSLPLS---------SGSV 689
                              :||...|..|:|..|            |.|.|.|         :|| 
  Rat   472 PGDGGSRCDYLDEKGIETYLIIASKPEVKKTAQNGLNGSALPNGAPASKPSSPALIETKEPNGS- 535

  Fly   690 CKRTCCDRSNACRHRAIEQEPLAGRSS-PSGQSDRDLLAKDKDDEFVLAHARVLQEEQQLEMLDE 753
                 ...|.:....|.|||..|...| |:.:  |.|..:|..|..|.|.    ::|.:|..|  
  Rat   536 -----AHASGSTSEEAEEQEAQADNPSFPNPR--RRLRLQDLADRVVDAS----EDEHELNQL-- 587

  Fly   754 TESVSESVLSEEQFKCWEYMLEQNTQLL----FDKELNT 788
               ::|::|..|..   :.:.::||.||    .|.|:.|
  Rat   588 ---LNEALLERESA---QVVKKRNTFLLTMRFMDPEMET 620

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380
LRR_8 109..169 CDD:290566
leucine-rich repeat 111..135 CDD:275380
leucine-rich repeat 136..158 CDD:275380
leucine-rich repeat 159..183 CDD:275380
leucine-rich repeat 184..209 CDD:275380
LRR_8 205..266 CDD:290566
leucine-rich repeat 210..230 CDD:275380
leucine-rich repeat 232..255 CDD:275380
LRR_RI <256..410 CDD:238064 29/116 (25%)
leucine-rich repeat 256..276 CDD:275380
LRR_8 279..359 CDD:290566 15/62 (24%)
leucine-rich repeat 280..303 CDD:275380 2/6 (33%)
leucine-rich repeat 304..348 CDD:275380 11/43 (26%)
leucine-rich repeat 349..372 CDD:275380 5/22 (23%)
PP2Cc 461..655 CDD:294085 39/212 (18%)
Adcy3NP_570135.2 AC_N <44..303 CDD:318454 30/134 (22%)
Guanylate_cyc 310..494 CDD:306677 46/250 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 504..563 15/66 (23%)
Guanylate_cyc 914..1121 CDD:306677
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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