DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and Lrrc4

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001032413.1	Gene:	Lrrc4 / 641521	RGDID:	1560026	Length:	652	Species:	Rattus norvegicus

Alignment Length:	686	Identity:	128/686 - (18%)
Similarity:	232/686 - (33%)	Gaps:	216/686 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SASHSGPHPLPVEVTAAEEEQAATFGQTSPQKLSLKGSQLGGSILIGNYNYLTQLEVCENEMEVL 83
            :|:.:||...|...:.:.:     |.:....:..|.....|   :..|..|   |.:.||.::::
  Rat    36 AAASAGPQNCPSVCSCSNQ-----FSKVVCTRRGLSEVPQG---IPSNTRY---LNLMENNIQMI 89

  Fly    84 DLSS---LAQLETLKCSRNKLMELIINGTN----LQTLVADHNYLHNISTTNTHPVPLKLQRIDI 141
            ...:   |..||.|:..||.:.::.:...|    |.||....|:| .:..:.......||:.:.:
  Rat    90 QADTFRHLHHLEVLQLGRNAIRQIEVGAFNGLASLNTLELFDNWL-TVIPSGAFEYLSKLRELWL 153

  Fly   142 SHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPEG--- 203
            .:|....:|::        |.|                |:..|:.|||  .:||:|:...||
  Rat   154 RNNPIESIPSY--------AFN----------------RVPSLMRLDL--GELKKLEYISEGAFE 192

  Fly   204 -----------------------FSSIRSLQLQSNELPSL-PDNFFAVTHARLETLNVSCNKLST 244
                                   ...:..|::..|..|.: |.:|..:  :.|:.|.|..:::|.
  Rat   193 GLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGL--SSLKKLWVMNSQVSL 255

  Fly   245 LPRYEQNNHAALVNLSLAGNHLND---SIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEI 306
            :.|...:..|:||.|:||.|:|:.   .:|.||....:   |||.:|     |..|     :.:|
  Rat   256 IERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVE---LHLHHN-----PWNC-----DCDI 307

  Fly   307 LVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSR 371
            |.|:..:.:.:|....         ||..   |...:.......|      .:|:.:.....|.
  Rat   308 LWLAWWLREYIPTNST---------CCGR---CHAPMHMRGRYLV------EVDQASFQCSAPF- 353

  Fly   372 NLKYLDLSGNLQLQVDEQQFKVCQS--QSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSG 434
               .:|...:|.:..|......|::  .|...|           .||...:...:::..:.....
  Rat   354 ---IMDAPRDLNISEDRMAELKCRTPPMSSVKW-----------LLPNGTVLSHASRHPRISVLN 404

  Fly   435 PWTMGFAETPGSGDCRKL----SVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMK 495
            ..|:.|:        |.|    .||.....|..|:..|
  Rat   405 DGTLNFS--------RVLLIDTGVYTCMVTNVAGNSNA--------------------------- 434

  Fly   496 QEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAAL------FHLTRTRAPSKVRP--LKSKRYVLRM 552
                   ||   |:            :|.||.|      |..|.|...:::.|  :..|...:..
  Rat   435 -------SA---YL------------NVSSAELNTPNFSFFTTVTVETTEISPEDITRKYKPVPT 477

  Fly   553 ASTGGLDAYLIRRTSQLRLTK-PDVIQKDQIHSMPDPHVLELILSNDDEY-----LVVGNAQLWS 611
            .|||...||....|..::.|: |..:      .:|.....:.:.::.||.     :::|   .:.
  Rat   478 TSTGYQPAYTTSTTVLIQTTRVPKQV------PVPSTDTTDKMQTSLDEVMKTTKIIIG---CFV 533

  Fly   612 VMDIDRAAREI-------RKEENSLLAAKRLVDIAQ 640
            .:.:..||..|       |.::.|.:.|.|.|:|.|
  Rat   534 AVTLLAAAMLIVFYKLRKRHQQRSTVTAARTVEIIQ 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	5/18 (28%)
		LRR_8	109..169	CDD:290566	12/63 (19%)
		leucine-rich repeat	111..135	CDD:275380	5/23 (22%)
		leucine-rich repeat	136..158	CDD:275380	3/21 (14%)
		leucine-rich repeat	159..183	CDD:275380	3/23 (13%)
		leucine-rich repeat	184..209	CDD:275380	9/50 (18%)
		LRR_8	205..266	CDD:290566	17/61 (28%)
		leucine-rich repeat	210..230	CDD:275380	5/20 (25%)
		leucine-rich repeat	232..255	CDD:275380	5/22 (23%)
		LRR_RI	<256..410	CDD:238064	32/158 (20%)
		leucine-rich repeat	256..276	CDD:275380	10/22 (45%)
		LRR_8	279..359	CDD:290566	14/79 (18%)
		leucine-rich repeat	280..303	CDD:275380	6/22 (27%)
		leucine-rich repeat	304..348	CDD:275380	7/43 (16%)
		leucine-rich repeat	349..372	CDD:275380	3/22 (14%)
		PP2Cc	461..655	CDD:294085	37/201 (18%)
Lrrc4	NP_001032413.1	LRRNT	45..78	CDD:214470	5/40 (13%)
		LRR_8	74..132	CDD:404697	15/60 (25%)
		LRR 1	75..96		5/23 (22%)
		leucine-rich repeat	76..99	CDD:275380	5/25 (20%)
		PPP1R42	96..300	CDD:411060	53/240 (22%)
		LRR 2	99..120		5/20 (25%)
		leucine-rich repeat	100..123	CDD:275380	6/22 (27%)
		LRR 3	123..144		5/21 (24%)
		leucine-rich repeat	124..147	CDD:275380	5/23 (22%)
		LRR 4	147..168		6/44 (14%)
		leucine-rich repeat	148..171	CDD:275380	6/46 (13%)
		LRR 5	171..193		9/23 (39%)
		leucine-rich repeat	172..196	CDD:275380	9/25 (36%)
		LRR 6	196..217		0/20 (0%)
		leucine-rich repeat	197..218	CDD:275380	0/20 (0%)
		LRR 7	218..239		5/20 (25%)
		leucine-rich repeat	219..242	CDD:275380	5/24 (21%)
		LRR 8	242..263		5/20 (25%)
		leucine-rich repeat	243..266	CDD:275380	5/22 (23%)
		LRR 9	266..287		8/20 (40%)
		leucine-rich repeat	267..288	CDD:275380	8/20 (40%)
		LRRCT	299..350	CDD:214507	12/78 (15%)
		IG_like	358..440	CDD:214653	19/149 (13%)
		Ig strand B	369..373	CDD:409353	0/3 (0%)
		Ig strand C	380..384	CDD:409353	1/14 (7%)
		Ig strand E	406..410	CDD:409353	1/3 (33%)
		Ig strand F	420..425	CDD:409353	2/4 (50%)
		Ig strand G	433..436	CDD:409353	1/36 (3%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000