DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and LRRC4

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_071426.1	Gene:	LRRC4 / 64101	HGNCID:	15586	Length:	653	Species:	Homo sapiens

Alignment Length:	573	Identity:	118/573 - (20%)
Similarity:	217/573 - (37%)	Gaps:	124/573 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 KLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNV-AVLLRNYRITELVSLDLAYNDLKQLD 198
            :..::..:....||:|.  |..::...:|...|.:..: |...|:....|:  |.|..|.::|::
Human    55 QFSKVVCTRRGLSEVPQ--GIPSNTRYLNLMENNIQMIQADTFRHLHHLEV--LQLGRNSIRQIE 115

  Fly   199 --QFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSL 261
              .| .|.:|:.:|:|..|.|..:|...|... ::|..|.:..|.:.::|.|..|...:|:.|.|
Human   116 VGAF-NGLASLNTLELFDNWLTVIPSGAFEYL-SKLRELWLRNNPIESIPSYAFNRVPSLMRLDL 178

  Fly   262 AG----NHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAAC-VRNWPE------LEILVLSGNMLQ 315
            ..    .::::..||.|.|        |.|..:|:    | :::.|.      ||.|.:|||...
Human   179 GELKKLEYISEGAFEGLFN--------LKYLNLGM----CNIKDMPNLTPLVGLEELEMSGNHFP 231

  Fly   316 QL-PEEVATLGQLRVLRCCNNLLLCTPQLA--KLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLD 377
            :: |.....|..|:.|...|:.:....:.|  .||.|..|:|:||:|..:......|.|.|..|.
Human   232 EIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELH 296

  Fly   378 LSGN--------------LQLQVDEQQFKVCQSQSQRHWS---LVDVSGNNRAALPTTKIRQVSA 425
            |..|              |:..:........:..:..|..   ||:|   ::|:...:....:.|
Human   297 LHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEV---DQASFQCSAPFIMDA 358

  Fly   426 QRNQNKTSGPWTMGFAETPGSGDCR----------------KLSVYQLRAANYGG---SDEALYG 471
            .|:.|.:.|........||.....:                ::||......|:..   ||..:|.
Human   359 PRDLNISEGRMAELKCRTPPMSSVKWLLPNGTVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYT 423

  Fly   472 -MFEALEGRGRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAALFHLTRTR 535
             |...:.|...|:..::....:|          ...:|..||.:       :|.:..:.....||
Human   424 CMVTNVAGNSNASAYLNVSTAEL----------NTSNYSFFTTV-------TVETTEISPEDTTR 471

  Fly   536 APSKVRPLKSKRYVLRMASTGGLDAYLIRRTSQLRLTK-PDVIQKDQIHSMPDPHVLELILSNDD 599
               |.:|:.:       .|||...||....|..::.|: |..:      ::|.....:.:.::.|
Human   472 ---KYKPVPT-------TSTGYQPAYTTSTTVLIQTTRVPKQV------AVPATDTTDKMQTSLD 520

  Fly   600 EY-----LVVGNAQLWSVMDIDRAAREI-------RKEENSLLAAKRLVDIAQ 640
            |.     :::|   .:..:.:..||..|       |.::.|.:.|.|.|:|.|
Human   521 EVMKTTKIIIG---CFVAVTLLAAAMLIVFYKLRKRHQQRSTVTAARTVEIIQ 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566	6/33 (18%)
		leucine-rich repeat	111..135	CDD:275380	118/573 (21%)
		leucine-rich repeat	136..158	CDD:275380	4/21 (19%)
		leucine-rich repeat	159..183	CDD:275380	4/24 (17%)
		leucine-rich repeat	184..209	CDD:275380	7/26 (27%)
		LRR_8	205..266	CDD:290566	16/64 (25%)
		leucine-rich repeat	210..230	CDD:275380	6/19 (32%)
		leucine-rich repeat	232..255	CDD:275380	6/22 (27%)
		LRR_RI	<256..410	CDD:238064	43/184 (23%)
		leucine-rich repeat	256..276	CDD:275380	6/23 (26%)
		LRR_8	279..359	CDD:290566	24/89 (27%)
		leucine-rich repeat	280..303	CDD:275380	4/23 (17%)
		leucine-rich repeat	304..348	CDD:275380	13/46 (28%)
		leucine-rich repeat	349..372	CDD:275380	7/22 (32%)
		PP2Cc	461..655	CDD:294085	38/197 (19%)
LRRC4	NP_071426.1	LRRNT	46..79	CDD:214470	4/25 (16%)
		LRR	<74..291	CDD:227223	57/232 (25%)
		LRR 1	76..97		3/20 (15%)
		leucine-rich repeat	77..100	CDD:275380	4/22 (18%)
		LRR 2	100..121		6/23 (26%)
		leucine-rich repeat	101..124	CDD:275380	7/25 (28%)
		LRR 3	124..145		7/20 (35%)
		leucine-rich repeat	125..148	CDD:275380	6/23 (26%)
		LRR 4	148..169		5/20 (25%)
		leucine-rich repeat	149..172	CDD:275380	6/22 (27%)
		LRR 5	172..194		4/21 (19%)
		leucine-rich repeat	173..197	CDD:275380	6/23 (26%)
		LRR 6	197..218		6/32 (19%)
		leucine-rich repeat	198..219	CDD:275380	5/24 (21%)
		LRR 7	219..240		7/20 (35%)
		leucine-rich repeat	220..243	CDD:275380	8/22 (36%)
		LRR 8	243..264		4/20 (20%)
		leucine-rich repeat	244..267	CDD:275380	5/22 (23%)
		LRR 9	267..288		6/20 (30%)
		leucine-rich repeat	268..289	CDD:275380	6/20 (30%)
		LRRCT	300..351	CDD:214507	7/53 (13%)
		IG	359..441	CDD:214652	14/81 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000