DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and Gucy1a1

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001343916.1	Gene:	Gucy1a1 / 60596	MGIID:	1926562	Length:	691	Species:	Mus musculus

Alignment Length:	434	Identity:	82/434 - (18%)
Similarity:	133/434 - (30%)	Gaps:	157/434 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   569 LRLTKPDVIQKDQIHSMPDPHVL-------ELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEE 626
            ::.|||.:.......|:..|..|       ..:|..|...|.:||.....|...|...:...:|.
Mouse   259 VKSTKPSLSPGKPQSSLVIPASLFCKTFPFHFMLDRDLAILQLGNGIRRLVNKRDFQGKPNFEEF 323

  Fly   627 NSLLAAKRLVDIAQSFAAAESL--SVIVVRFRHLGTDVDHLIRELKQSVRKKPQPVSLPLSS--- 686
            ..:|..|    |.|:|:...::  ...|:|.|..    |:.:::..:.:..|.|.:.:..||
Mouse   324 FEILTPK----INQTFSGIMTMLNMQFVIRVRRW----DNSVKKSSRVMDLKGQMIYIVESSAIL 380

  Fly   687 --GSVCKRTCCDR-----------SNACRHRAIEQEPLAGRSSPSGQSDRDLLAKDKDDEFVLAH 738
              ||    .|.||           |:...|.|:....|.|..:.:....:..|.|.|   ..|.|
Mouse   381 FLGS----PCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLK---ATLEH 438

  Fly   739 ARVLQEEQQLEMLDETESVSESVLSEEQFKCWEYMLEQN------TQLLFD-------------- 783
            |....||::...:|...|:..|.::::   .|:..:.|.      |.|..|
Mouse   439 AHQALEEEKKRTVDLLCSIFPSEVAQQ---LWQGQIVQAKKFSEVTMLFSDIVGFTAICSQCSPL 500

  Fly   784 ---KELNTISKSFTKQ----------------------------RTVPNAIMAATVLPERND--- 814
               ..||.:...|.:|                            ..|..|:||..::...|:
Mouse   501 QVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHRESDTHAVQIALMALKMMELSNEVMS 565

  Fly   815 -------------------------------FTSNLMRTVTNKFISTSTPQLPQPITTSVPLGSY 848
                                           |.:|:  |:.|||.|.|.|:     ..:|...:|
Mouse   566 PHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNV--TLANKFESCSVPR-----KINVSPTTY 623

  Fly   849 HQVKQAP--------------------PG--HFGSALSFQQAHS 870
            ..:|..|                    ||  ||..|...|..:|
Mouse   624 RLLKDCPGFVFTPRSREELPPNFPSDIPGICHFLDAYHHQGPNS 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380
		leucine-rich repeat	184..209	CDD:275380
		LRR_8	205..266	CDD:290566
		leucine-rich repeat	210..230	CDD:275380
		leucine-rich repeat	232..255	CDD:275380
		LRR_RI	<256..410	CDD:238064
		leucine-rich repeat	256..276	CDD:275380
		LRR_8	279..359	CDD:290566
		leucine-rich repeat	280..303	CDD:275380
		leucine-rich repeat	304..348	CDD:275380
		leucine-rich repeat	349..372	CDD:275380
		PP2Cc	461..655	CDD:294085	20/94 (21%)
Gucy1a1	NP_001343916.1	HNOBA	277..466	CDD:311573	44/206 (21%)
Gucy1a1	NP_001343916.1	Guanylate_cyc	472..643	CDD:306677	26/177 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900