DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Phlpp and LGR6

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_001017403.1 Gene:LGR6 / 59352 HGNCID:19719 Length:967 Species:Homo sapiens


Alignment Length:588 Identity:134/588 - (22%)
Similarity:204/588 - (34%) Gaps:179/588 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 ASHSGPHPLPVEVTAAEEEQAATFGQTSPQKLSLKGSQLGGSILIGNYNYLTQLEVCENEMEVLD 84
            |...||.|     ||.   .|....|.....||...|:||.|.:.|:.:.||         ..||
Human    25 APQPGPGP-----TAC---PAPCHCQEDGIMLSADCSELGLSAVPGDLDPLT---------AYLD 72

  Fly    85 LSSLAQLETLKCSRNKLMELIINGTNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSEL 149
            |           |.|.|.||            .....|::..         |:.:.:|.|:.|.:
Human    73 L-----------SMNNLTEL------------QPGLFHHLRF---------LEELRLSGNHLSHI 105

  Fly   150 PNWV-GACASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFP----EGFSSIRS 209
            |... ....||..:...:|:|..:..    ..:.||.||.....|...:...|    ||.||:|.
Human   106 PGQAFSGLYSLKILMLQNNQLGGIPA----EALWELPSLQSLRLDANLISLVPERSFEGLSSLRH 166

  Fly   210 LQLQSNELPSLP----DNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGN---HLN 267
            |.|..|.|..:|    :|..|     |:.:.::.|::|.:|.|...|..:||.|.|..|   ||.
Human   167 LWLDDNALTEIPVRALNNLPA-----LQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLG 226

  Fly   268 DSIFEPLHNAAKLRVLHLAYNRIGVLPAA------------------------------------ 296
            ...||.|||   |..|.|.||::...|.|                                    
Human   227 THSFEGLHN---LETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHF 288

  Fly   297 -----------CVRNWPELEILVLSGNM-LQQLPE-------EVAT----------------LGQ 326
                       ..:..|:|..|.|:|.| :|:.|:       |:.|                |.:
Human   289 YDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPR 353

  Fly   327 LRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQF 391
            ||||...:|.:...|.|.:...|:.:.|.||.:..:.........:|:.||||.|....:..:.|
Human   354 LRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAF 418

  Fly   392 KVCQSQSQRHWSLVDVSGNNRAALPTT--------KIR-QVSAQRNQNKTSGPWTMGFAETPGSG 447
            ....|..:     :|::.|....||..        |:: .::..:..:|.|.| .:...|.|.:.
Human   419 STLHSLVK-----LDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFP-KLRILEVPYAY 477

  Fly   448 DCRKLSVYQLRAANYGGSDEALYGMFEA-------LEGRGR-----AAQEMSHLVPDLMKQEQMV 500
            .|   ..|.:.|:.:..|     |.:||       .|...|     |.|..:|...||.:.:..:
Human   478 QC---CPYGMCASFFKAS-----GQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEM 534

  Fly   501 KDS 503
            :||
Human   535 EDS 537

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380 5/18 (28%)
LRR_8 109..169 CDD:290566 9/60 (15%)
leucine-rich repeat 111..135 CDD:275380 1/23 (4%)
leucine-rich repeat 136..158 CDD:275380 5/22 (23%)
leucine-rich repeat 159..183 CDD:275380 3/23 (13%)
leucine-rich repeat 184..209 CDD:275380 9/28 (32%)
LRR_8 205..266 CDD:290566 21/67 (31%)
leucine-rich repeat 210..230 CDD:275380 7/23 (30%)
leucine-rich repeat 232..255 CDD:275380 6/22 (27%)
LRR_RI <256..410 CDD:238064 50/227 (22%)
leucine-rich repeat 256..276 CDD:275380 10/22 (45%)
LRR_8 279..359 CDD:290566 29/150 (19%)
leucine-rich repeat 280..303 CDD:275380 7/69 (10%)
leucine-rich repeat 304..348 CDD:275380 17/67 (25%)
leucine-rich repeat 349..372 CDD:275380 4/22 (18%)
PP2Cc 461..655 CDD:294085 13/55 (24%)
LGR6NP_001017403.1 LRRNT 34..68 CDD:214470 10/36 (28%)
LRR_RI <57..199 CDD:238064 42/191 (22%)
leucine-rich repeat 70..91 CDD:275380 9/43 (21%)
LRR 1 91..112 5/29 (17%)
LRR_8 92..150 CDD:290566 14/61 (23%)
leucine-rich repeat 92..115 CDD:275380 5/22 (23%)
LRR 2 115..136 4/24 (17%)
leucine-rich repeat 116..139 CDD:275380 5/26 (19%)
LRR_RI 131..392 CDD:238064 65/272 (24%)
LRR 3 139..160 4/20 (20%)
leucine-rich repeat 140..163 CDD:275380 5/22 (23%)
LRR 4 163..186 8/22 (36%)
leucine-rich repeat 164..187 CDD:275380 7/22 (32%)
LRR_8 186..246 CDD:290566 24/67 (36%)
LRR 5 187..208 6/25 (24%)
leucine-rich repeat 188..211 CDD:275380 6/22 (27%)
LRR 6 211..232 8/20 (40%)
leucine-rich repeat 212..235 CDD:275380 10/22 (45%)
LRR 7 235..256 8/23 (35%)
leucine-rich repeat 236..258 CDD:275380 7/21 (33%)
LRR_8 258..314 CDD:290566 4/55 (7%)
LRR 8 258..279 0/20 (0%)
leucine-rich repeat 259..282 CDD:275380 0/22 (0%)
LRR 9 282..303 0/20 (0%)
leucine-rich repeat 283..304 CDD:275380 0/20 (0%)
LRR 10 306..328 7/21 (33%)
LRR 11 329..350 2/20 (10%)
leucine-rich repeat 330..344 CDD:275378 2/13 (15%)
LRR 12 353..374 7/20 (35%)
leucine-rich repeat 354..399 CDD:275380 11/44 (25%)
LRR_8 375..434 CDD:290566 14/63 (22%)
LRR 13 375..396 4/20 (20%)
leucine-rich repeat 376..390 CDD:275378 4/13 (31%)
LRR 14 399..420 7/20 (35%)
leucine-rich repeat 400..423 CDD:275380 7/22 (32%)
LRR 15 423..443 5/24 (21%)
leucine-rich repeat 424..444 CDD:275380 4/24 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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