DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and Phlpp1

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_038946976.1	Gene:	Phlpp1 / 59265	RGDID:	621308	Length:	1718	Species:	Rattus norvegicus

Alignment Length:	938	Identity:	228/938 - (24%)
Similarity:	375/938 - (39%)	Gaps:	217/938 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 YLTQLEVCENEMEVLDLSSLAQLETLKCSRNKLMELIINGTNLQTLVADHNYLHNISTTNTHPVP 133
            ::|||::.:|::..||......:|.|.|.||:|:.|.|.|..|:.|.|..|.|..:   :.:|||
  Rat   795 HVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLNICGYFLKALYASSNELVQL---DVYPVP 856

  Fly   134 LKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNV-AVLLRNYRITELVSLDLAYNDLKQL 197
            ..|..:|:|.|....:|.||.....|..::..||::..: |.|..|..:.:|::   .:|.|.:|
  Rat   857 NYLSYMDVSRNCLESVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLA---GHNRLARL 918

  Fly   198 DQFPEGF--SSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLP--RYEQNNHAALVN 258
               ||..  :|:..|.:|.|::..||.|......: |..||.|.|||.|||  ...:...:.|..
  Rat   919 ---PERLERTSVEVLDVQHNQIIELPPNLLMKADS-LRFLNASANKLETLPPATLSEETSSILQE 979

  Fly   259 LSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVAT 323
            |.|..|.|.|.....|....:|::||:||||:...||:.:....|||.:.:|||.|:.:|..:..
  Rat   980 LYLTNNSLTDKCVPLLTGHPRLKILHMAYNRLQSFPASKMAKLEELEEIDISGNKLKAIPTTIMN 1044

  Fly   324 LGQLRVLRCCNNLLLCTPQLAKLAMLK--------------------VLDLSHNHLDRVNLLALV 368
            ..::..:...:|.:...|::.:|..:|                    .:|||.|.|..:.|...:
  Rat  1045 CRRMHTVIAHSNCIEVFPEVMQLPEVKSTEGNGSLSRSSFLFPLFHQCVDLSCNELSEITLPENL 1109

  Fly   369 PSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTS 433
            |.: |:.|||:||.:|.:|.:..::.               ||   :...||.|.||    ...|
  Rat  1110 PPK-LQELDLTGNPRLALDHKSLELL---------------NN---IRCFKIDQPSA----GDAS 1151

  Fly   434 GP---WTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMK 495
            |.   |:.|:.|  .||...||.|..|...|:..:.|||||:|:     |....|:.:|:...|.
  Rat  1152 GAPAVWSHGYTE--ASGVKNKLCVAALSVNNFRDNREALYGVFD-----GDRNVEVPYLLQCTMS 1209

  Fly   496 Q---EQMVKDSAVRDYMKFTLLAAQQQCGSV-----RSAALFHLTRTRAPSKVRPLK-SKRYVLR 551
            .   |::.|.....:||..|.:..|::.|:.     .:|.|.|:...       |:. ...:.|.
  Rat  1210 DILAEELQKTKNEEEYMVNTFIVMQRKLGTAGQKLGGAAVLCHIRHD-------PVDLGGSFTLT 1267

  Fly   552 MASTGGLDAYLIRRTSQLRLTK----------------PDVIQKDQ----------------IHS 584
            .|:.|.....|.|....|.|::                ..:|.:|.                :|.
  Rat  1268 SANVGKCQTVLCRNGKPLSLSRSYTMSCEEERKRIKQHKAIITEDGKVNGVTESTRILGYTFLHP 1332

  Fly   585 --MPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAES 647
              :|.|||..::|:..||:.::|:..||..:.|:.|...:|...::|.|||:|..:|||:...:|
  Rat  1333 SVVPRPHVQSVLLTPQDEFFILGSKGLWDSLSIEEAVEAVRNVPDALAAAKKLCTLAQSYGCHDS 1397

  Fly   648 LSVIVVRFRHLGTDVDHLI-------------------RELKQSVRKKPQP-VSLPLSSGSVCKR 692
            :|.:||:   |....|...                   ..:...::.:|.. :.:|.||..:...
  Rat  1398 ISAVVVQ---LSVTEDSFCCCELSVGGSMPPPSPGIFPPSVSMVIKDRPSDGLGVPSSSSGMASE 1459

  Fly   693 TCCDRSNACRHRAI----EQEPLAG---RSSP-----------------------------SGQS 721
            ...:.|.:.....:    ..||.:|   .|||                             |..|
  Rat  1460 ISSELSTSEMSSEVGSTASDEPPSGALSESSPAYPSEQRCMLHPVCLSNSFQRQLSSATFSSAFS 1524

  Fly   722 DRDLLAKDKDDE---------------FVLAH-ARVLQEEQQLEMLDETESVSES--VLSEEQFK 768
            |..|   |.|||               .|..| :|..::|:|..:|......|:.  |:|..:.
  Rat  1525 DNGL---DSDDEEPIEGVFSNGSRVEVEVDIHCSRAKEKERQQHLLQVPAEASDEGIVISANED- 1585

  Fly   769 CWEYMLEQNTQLLFDKELNTISK-----SFTKQRTVPNAIMAATVLPERND---FTSNLMRTVTN 825
              |..|.:.|.:   ..:.||.:     |...|....|.|..||..|.|..   |.:.......:
  Rat  1586 --ESGLSKKTDI---SAVGTIGRRRANGSVAPQERSHNVIEVATDAPLRKPGGYFAAPAQPDPDD 1645

  Fly   826 KFISTSTPQLPQPITTSVPLGSYHQVKQ 853
            :||  ..|:|.:.:.   .:..:||.:|
  Rat  1646 QFI--IPPELEEEVK---EIMKHHQEQQ 1668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	9/18 (50%)
		LRR_8	109..169	CDD:290566	18/59 (31%)
		leucine-rich repeat	111..135	CDD:275380	8/23 (35%)
		leucine-rich repeat	136..158	CDD:275380	7/21 (33%)
		leucine-rich repeat	159..183	CDD:275380	6/24 (25%)
		leucine-rich repeat	184..209	CDD:275380	7/26 (27%)
		LRR_8	205..266	CDD:290566	21/62 (34%)
		leucine-rich repeat	210..230	CDD:275380	6/19 (32%)
		leucine-rich repeat	232..255	CDD:275380	10/24 (42%)
		LRR_RI	<256..410	CDD:238064	43/173 (25%)
		leucine-rich repeat	256..276	CDD:275380	7/19 (37%)
		LRR_8	279..359	CDD:290566	25/99 (25%)
		leucine-rich repeat	280..303	CDD:275380	9/22 (41%)
		leucine-rich repeat	304..348	CDD:275380	10/43 (23%)
		leucine-rich repeat	349..372	CDD:275380	8/42 (19%)
		PP2Cc	461..655	CDD:294085	57/236 (24%)
Phlpp1	XP_038946976.1	Ubiquitin_like_fold	176..>224	CDD:421700
		PHA03247	<237..443	CDD:223021
		RA_PHLPP1	<424..491	CDD:340760
		PH_PHLPP-like	498..594	CDD:270131
		PLN00113	602..>1109	CDD:215061	93/323 (29%)
		leucine-rich repeat	604..624	CDD:275380
		leucine-rich repeat	625..655	CDD:275380
		leucine-rich repeat	679..701	CDD:275380
		leucine-rich repeat	702..724	CDD:275380
		leucine-rich repeat	725..771	CDD:275380
		leucine-rich repeat	772..795	CDD:275380	228/938 (24%)
		leucine-rich repeat	796..816	CDD:275380	6/19 (32%)
		leucine-rich repeat	817..858	CDD:275380	17/43 (40%)
		leucine-rich repeat	859..881	CDD:275380	7/21 (33%)
		leucine-rich repeat	882..904	CDD:275380	6/21 (29%)
		leucine-rich repeat	905..926	CDD:275380	6/26 (23%)
		leucine-rich repeat	927..950	CDD:275380	6/22 (27%)
		leucine-rich repeat	951..974	CDD:275380	10/22 (45%)
		leucine-rich repeat	977..1000	CDD:275380	7/22 (32%)
		leucine-rich repeat	1001..1024	CDD:275380	9/22 (41%)
		leucine-rich repeat	1067..1112	CDD:275380	9/44 (20%)
		PP2Cc	1151..1403	CDD:214625	66/265 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9293
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	194	1.000	Inparanoid score	I3757
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172467at2759
OrthoFinder	1	1.000	-	-		FOG0003647
OrthoInspector	1	1.000	-	-		otm45597
orthoMCL	1	0.900	-	-		OOG6_102913
Panther	1	1.100	-	-	O	PTHR45752
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830