DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and LRFN1

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_065913.1	Gene:	LRFN1 / 57622	HGNCID:	29290	Length:	771	Species:	Homo sapiens

Alignment Length:	762	Identity:	154/762 - (20%)
Similarity:	247/762 - (32%)	Gaps:	229/762 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 RLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPA 295
            |:..|.::.|.::.:.|.:..|..:||:|:|:.|.:.........:...||.|||..||:..:..
Human    66 RVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRG 130

  Fly   296 ACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLD 360
            ..:|....|..|:|..|.::::  |.|...                  |.|:.::.||||:|:|:
Human   131 DQLRGLGNLRHLILGNNQIRRV--ESAAFD------------------AFLSTVEDLDLSYNNLE 175

  Fly   361 RVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLV--DVSGNNRAALPTTKIRQV 423
            .:...|:....||..|.|..||...:.|..|      .|.| .||  |::.|....||...: .:
Human   176 ALPWEAVGQMVNLNTLTLDHNLIDHIAEGTF------VQLH-KLVRLDMTSNRLHKLPPDGL-FL 232

  Fly   424 SAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQL------------------------------- 457
            .:|....|...|.|:.|...|...:|..|.:.:|
Human   233 RSQGTGPKPPTPLTVSFGGNPLHCNCELLWLRRLTREDDLETCATPEHLTDRYFWSIPEEEFLCE 297

  Fly   458 -----RAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKDSA------------- 504
                 |.|  ||  .||....:|:..|.||..:...:|..:....:::.:|:
Human   298 PPLITRQA--GG--RALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGTLDVT 358

  Fly   505 ---VRDYMKFTLLAAQ---------QQCGSVRSAALFHLTRTRAPSKVRPLKSKRYVLRMASTGG 557
               :||...||.:|:.         :.|  |....|........|....|..|.  :......|.
Human   359 ITTLRDSGTFTCIASNAAGEATAPVEVC--VVPLPLMAPPPAAPPPLTEPGSSD--IATPGRPGA 419

  Fly   558 LDAYLIRRTSQLRLTKPDVI---------------QKDQIHSMPDPHVLELILSNDDEYLV---- 603
            .|:...||.....||...|:               |.....|:.|..|..:|.|....:||
Human   420 NDSAAERRLVAAELTSNSVLIRWPAQRPVPGIRMYQVQYNSSVDDSLVYRMIPSTSQTFLVNDLA 484

  Fly   604 VGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAES--------------------- 647
            .|.|       .|.....:..:..:.|.|.|:|...|...|.:.
Human   485 AGRA-------YDLCVLAVYDDGATALPATRVVGCVQFTTAGDPAPCRPLRAHFLGGTMIIAIGG 542

  Fly   648 ---------LSVIVVRFRHLGTDVDHLIRELKQSVRKKPQPVSLPLSSGSVCKRTCCDRSNACRH 703
                     :.::::|::..| |.|.  |.:|.|       .|||..| .||.:|     |.
Human   543 VIVASVLVFIVLLMIRYKVYG-DGDS--RRVKGS-------RSLPRVS-HVCSQT-----NG--- 588

  Fly   704 RAIEQEPLAGRSSPSGQSDRDLLAKDKDDEFVLAHARVLQEEQQLEMLDETESVSESVLSEEQFK 768
                    ||..:                    |.|..|..:...|.|.|.||.:...::.|...
Human   589 --------AGTGA--------------------AQAPALPAQDHYEALREVESQAAPAVAVEAKA 625

  Fly   769 CWEYMLEQNTQLLFDKELNTISKSFTKQRTVPNAIMA-----ATVLPERNDFTSNLMRTVTNKFI 828
            ..........:::..:.|   ..|.|....:|:...:     |.|.|.|:  .|..:..
Human   626 MEAETASAEPEVVLGRSL---GGSATSLCLLPSEETSGEESRAAVGPRRS--RSGALEP------ 679

  Fly   829 STSTPQLPQPITTSVPLGS----YHQVKQAPPGHFGSALSFQQAHSY 871
            .||.|    |....||.|:    ..|.:.:..|.:|:..   |:|||
Human   680 PTSAP----PTLALVPGGAAARPRPQQRYSFDGDYGALF---QSHSY 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380
		leucine-rich repeat	184..209	CDD:275380
		LRR_8	205..266	CDD:290566	10/34 (29%)
		leucine-rich repeat	210..230	CDD:275380
		leucine-rich repeat	232..255	CDD:275380	4/22 (18%)
		LRR_RI	<256..410	CDD:238064	41/155 (26%)
		leucine-rich repeat	256..276	CDD:275380	5/19 (26%)
		LRR_8	279..359	CDD:290566	21/79 (27%)
		leucine-rich repeat	280..303	CDD:275380	8/22 (36%)
		leucine-rich repeat	304..348	CDD:275380	8/43 (19%)
		leucine-rich repeat	349..372	CDD:275380	7/22 (32%)
		PP2Cc	461..655	CDD:294085	45/267 (17%)
LRFN1	NP_065913.1	LRR_RI	<65..174	CDD:238064	31/127 (24%)
		LRR_8	65..125	CDD:290566	16/58 (28%)
		LRR 1	66..87		4/20 (20%)
		leucine-rich repeat	67..90	CDD:275380	4/22 (18%)
		LRR 2	90..111		5/20 (25%)
		leucine-rich repeat	91..114	CDD:275380	5/22 (23%)
		LRR_8	113..174	CDD:290566	21/80 (26%)
		LRR 3	114..135		7/20 (35%)
		leucine-rich repeat	115..138	CDD:275380	8/22 (36%)
		LRR 4	138..159		6/40 (15%)
		leucine-rich repeat	139..163	CDD:275380	8/43 (19%)
		LRR_8	162..222	CDD:290566	21/66 (32%)
		LRR 5	163..184		7/20 (35%)
		leucine-rich repeat	164..187	CDD:275380	7/22 (32%)
		LRR_4	165..203	CDD:289563	13/37 (35%)
		LRR 6	187..208		8/26 (31%)
		leucine-rich repeat	188..211	CDD:275380	9/29 (31%)
		LRR 7	211..232		6/21 (29%)
		leucine-rich repeat	212..230	CDD:275380	6/17 (35%)
		LRRCT	252..>284	CDD:214507	4/31 (13%)
		IG_like	310..385	CDD:214653	12/74 (16%)
		Ig	314..387	CDD:299845	12/74 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..422		4/26 (15%)
		fn3	426..500	CDD:278470	16/80 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..743		20/81 (25%)
		PDZ-binding	768..771
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910