DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and LRRC7

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001357714.1	Gene:	LRRC7 / 57554	HGNCID:	18531	Length:	1575	Species:	Homo sapiens

Alignment Length:	1087	Identity:	236/1087 - (21%)
Similarity:	363/1087 - (33%)	Gaps:	344/1087 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 EVTAA----EEEQAATFGQTSPQKLSLKGSQLGGSILIGNYNYLTQLEVC------ENEMEVLDL 85
            ||.||    .||:......|:.:|            :||      :|..|      |..:.|||.
Human    21 EVRAALRKRPEEELQCLEMTTKRK------------IIG------RLVPCRCFRGEEEIISVLDY 67

  Fly    86 S--SLAQ-----------LETLKCSRNKLMEL---IINGTNLQTLVADHNYLHNISTTNTHPVPL 134
            |  ||.|           ||.|....|::.||   :.|...|:.|....|.|.|:.||....|.|
Human    68 SHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNL 132

  Fly   135 KLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQ 199
            |  .:|||.|...|.|..:..|..||.|.||.|                            .:.:
Human   133 K--ELDISKNGVQEFPENIKCCKCLTIIEASVN----------------------------PISK 167

  Fly   200 FPEGFSSIRSL-QLQSNE--LPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSL 261
            .|:||:.:.:| ||..|:  |..||.||..:  .:|..|.:..|.|.|||: ..:..|.|..|.|
Human   168 LPDGFTQLLNLTQLYLNDAFLEFLPANFGRL--VKLRILELRENHLKTLPK-SMHKLAQLERLDL 229

  Fly   262 AGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAAC----------------------VRNWPEL 304
            ..|...: :.|.|.....||.|.:..|.:.|||.:.                      :.....|
Human   230 GNNEFGE-LPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEAL 293

  Fly   305 EILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQ-LAKLAMLKVLDLSHNHLDRV------ 362
            |.|:||.|||||||:.:..|.:|..|:..:|.|...|. :..|::|:..|.|.|.|:.:
Human   294 EDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGY 358

  Fly   363 -----------NLLALVP-----SRNLKYLDLSGN-LQLQVDEQQFKVCQSQSQRHWSLVDVSGN 410
                       |.|..:|     .:|:..:.|..| |:...:|    :.|.|..|   ::::|.|
Human   359 LHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEE----IGQMQKLR---VLNLSDN 416

  Fly   411 NRAALP--TTKIRQVSA---QRNQNKTSGP-WTMGFAETPGSGDCRKLSVYQLRAANYGGSD--- 466
            ....||  .||:::::|   ..||:|...| .|....||..    |.|:.|.......|..|
Human   417 RLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQ----RVLTNYMFPQQPRGDEDFQS 477

  Fly   467 ------------EALYGMFEALEGRGRAA-QEMSHLVPDLMKQ---------------------- 496
                        :....|..|.|...:.. .|.:..|.||..|
Human   478 DSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDENAGKVKDLSCQAPWERGQRGITLQPARLSGDCC 542

  Fly   497 ------EQMVKDSAVRD---YMKFTLLAAQQQCGSVRSAALFHLTRTRAPS---KVRPLKSKRY- 548
                  :|.::|..|..   .:.:..::..||..|:.:........|..||   :...:..|||
Human   543 TPWARCDQQIQDMPVPQNDPQLAWGCISGLQQERSMCTPLPVAAQSTTLPSLSGRQVEINLKRYP 607

  Fly   549 ----------VLRMASTGGLDAYLIR-RTSQLRLTKPDVIQKDQIHSMPDPHVLELILSNDDEYL 602
                      |..:.:..|..::.:| ..|.........:::...|..|   |....::.:|.::
Human   608 TPYPEDLKNMVKSVQNLVGKPSHGVRVENSNPTANTEQTVKEKYEHKWP---VAPKEITVEDSFV 669

  Fly   603 VVGNAQLWSVMDIDRAAREI-----------RKEE------------NSLLAAKRLVDIAQSFAA 644
            ...|......:....|...:           :||.            |:.:::....|.:.|.|:
Human   670 HPANEMRIGELHPSLAETPLYPPKLVLLGKDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQAS 734

  Fly   645 AESLS--VIVVRFRHLGTDVDH-------LIRELKQSVRKKP---------------QPVSLPLS 685
            :.|.:  |.|...:....|..|       :.....|.:..||               :|..||:|
Human   735 SGSSNTRVKVGSLQTTAKDAVHNSLWGNRIAPSFPQPLDSKPLLSQREAVPPGNIPQRPDRLPMS 799

  Fly   686 ---------------SGSVCKRTCCDRSNACRHRAIEQEPLAGRSSPSGQSD--RDLLAKDKDDE 733
                           :|.|.:.|..:.:|:        .||....|.|..|.  |.|:.:|
Human   800 DTFTDNWTDGSHYDNTGFVAEETTAENANS--------NPLLSSKSRSTSSHGRRPLIRQD---- 852

  Fly   734 FVLAHARVLQEEQQLEMLDETESVSESVLSEEQFKCWEYMLEQNTQLLFDKELNTISKSFTKQRT 798
                  |::....:||......:....|.....::.|     ..|...|:......||..|...|
Human   853 ------RIVGVPLELEQSTHRHTPETEVPPSNPWQNW-----TRTPSPFEDRTAFPSKLETTPTT 906

  Fly   799 VPNAIMAATVLPERNDFTSNLMRTVTNKFISTSTPQLPQPITTSVPLGSYHQVKQAPPGHFGSAL 863
            .|        ||||.:            .|..|| ::|.|.:..|| ..||   .:.|..   :|
Human   907 SP--------LPERKE------------HIKEST-EIPSPFSPGVP-WEYH---DSNPNR---SL 943

  Fly   864 S--FQQAHSYGYNLFDAKPRPKFHGGTVKRSAGPNSAYFGSLQRLMP 908
            |  |.|.|.          ||:...|.:..|.        |.:||.|
Human   944 SNVFSQIHC----------RPESSKGVISISK--------STERLSP 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	7/21 (33%)
		LRR_8	109..169	CDD:290566	23/59 (39%)
		leucine-rich repeat	111..135	CDD:275380	8/23 (35%)
		leucine-rich repeat	136..158	CDD:275380	7/21 (33%)
		leucine-rich repeat	159..183	CDD:275380	6/23 (26%)
		leucine-rich repeat	184..209	CDD:275380	3/24 (13%)
		LRR_8	205..266	CDD:290566	21/63 (33%)
		leucine-rich repeat	210..230	CDD:275380	9/22 (41%)
		leucine-rich repeat	232..255	CDD:275380	7/22 (32%)
		LRR_RI	<256..410	CDD:238064	49/199 (25%)
		leucine-rich repeat	256..276	CDD:275380	6/19 (32%)
		LRR_8	279..359	CDD:290566	30/102 (29%)
		leucine-rich repeat	280..303	CDD:275380	7/44 (16%)
		leucine-rich repeat	304..348	CDD:275380	19/44 (43%)
		leucine-rich repeat	349..372	CDD:275380	8/44 (18%)
		PP2Cc	461..655	CDD:294085	41/280 (15%)
LRRC7	NP_001357714.1	leucine-rich repeat	64..85	CDD:275380	7/20 (35%)
		LRR_8	85..140	CDD:338972	20/56 (36%)
		leucine-rich repeat	86..108	CDD:275380	7/21 (33%)
		leucine-rich repeat	109..131	CDD:275380	7/21 (33%)
		LRR	130..440	CDD:227223	91/350 (26%)
		leucine-rich repeat	132..177	CDD:275380	18/74 (24%)
		leucine-rich repeat	178..200	CDD:275380	9/23 (39%)
		leucine-rich repeat	201..223	CDD:275380	7/22 (32%)
		leucine-rich repeat	224..246	CDD:275380	6/22 (27%)
		leucine-rich repeat	247..269	CDD:275380	7/21 (33%)
		leucine-rich repeat	270..292	CDD:275380	0/21 (0%)
		leucine-rich repeat	316..336	CDD:275380	5/19 (26%)
		leucine-rich repeat	339..361	CDD:275380	5/21 (24%)
		leucine-rich repeat	362..384	CDD:275380	3/21 (14%)
		leucine-rich repeat	385..407	CDD:275380	5/25 (20%)
		leucine-rich repeat	408..430	CDD:275380	7/24 (29%)
		PDZ_signaling	1485..1570	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910