DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and LRRC7

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_001357714.1 Gene:LRRC7 / 57554 HGNCID:18531 Length:1575 Species:Homo sapiens


Alignment Length:1087 Identity:236/1087 - (21%)
Similarity:363/1087 - (33%) Gaps:344/1087 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 EVTAA----EEEQAATFGQTSPQKLSLKGSQLGGSILIGNYNYLTQLEVC------ENEMEVLDL 85
            ||.||    .||:......|:.:|            :||      :|..|      |..:.|||.
Human    21 EVRAALRKRPEEELQCLEMTTKRK------------IIG------RLVPCRCFRGEEEIISVLDY 67

  Fly    86 S--SLAQ-----------LETLKCSRNKLMEL---IINGTNLQTLVADHNYLHNISTTNTHPVPL 134
            |  ||.|           ||.|....|::.||   :.|...|:.|....|.|.|:.||....|.|
Human    68 SHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNL 132

  Fly   135 KLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQ 199
            |  .:|||.|...|.|..:..|..||.|.||.|                            .:.:
Human   133 K--ELDISKNGVQEFPENIKCCKCLTIIEASVN----------------------------PISK 167

  Fly   200 FPEGFSSIRSL-QLQSNE--LPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSL 261
            .|:||:.:.:| ||..|:  |..||.||..:  .:|..|.:..|.|.|||: ..:..|.|..|.|
Human   168 LPDGFTQLLNLTQLYLNDAFLEFLPANFGRL--VKLRILELRENHLKTLPK-SMHKLAQLERLDL 229

  Fly   262 AGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAAC----------------------VRNWPEL 304
            ..|...: :.|.|.....||.|.:..|.:.|||.:.                      :.....|
Human   230 GNNEFGE-LPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEAL 293

  Fly   305 EILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQ-LAKLAMLKVLDLSHNHLDRV------ 362
            |.|:||.|||||||:.:..|.:|..|:..:|.|...|. :..|::|:..|.|.|.|:.:      
Human   294 EDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGY 358

  Fly   363 -----------NLLALVP-----SRNLKYLDLSGN-LQLQVDEQQFKVCQSQSQRHWSLVDVSGN 410
                       |.|..:|     .:|:..:.|..| |:...:|    :.|.|..|   ::::|.|
Human   359 LHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEE----IGQMQKLR---VLNLSDN 416

  Fly   411 NRAALP--TTKIRQVSA---QRNQNKTSGP-WTMGFAETPGSGDCRKLSVYQLRAANYGGSD--- 466
            ....||  .||:::::|   ..||:|...| .|....||..    |.|:.|.......|..|   
Human   417 RLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQ----RVLTNYMFPQQPRGDEDFQS 477

  Fly   467 ------------EALYGMFEALEGRGRAA-QEMSHLVPDLMKQ---------------------- 496
                        :....|..|.|...:.. .|.:..|.||..|                      
Human   478 DSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDENAGKVKDLSCQAPWERGQRGITLQPARLSGDCC 542

  Fly   497 ------EQMVKDSAVRD---YMKFTLLAAQQQCGSVRSAALFHLTRTRAPS---KVRPLKSKRY- 548
                  :|.::|..|..   .:.:..::..||..|:.:........|..||   :...:..||| 
Human   543 TPWARCDQQIQDMPVPQNDPQLAWGCISGLQQERSMCTPLPVAAQSTTLPSLSGRQVEINLKRYP 607

  Fly   549 ----------VLRMASTGGLDAYLIR-RTSQLRLTKPDVIQKDQIHSMPDPHVLELILSNDDEYL 602
                      |..:.:..|..::.:| ..|.........:::...|..|   |....::.:|.::
Human   608 TPYPEDLKNMVKSVQNLVGKPSHGVRVENSNPTANTEQTVKEKYEHKWP---VAPKEITVEDSFV 669

  Fly   603 VVGNAQLWSVMDIDRAAREI-----------RKEE------------NSLLAAKRLVDIAQSFAA 644
            ...|......:....|...:           :||.            |:.:::....|.:.|.|:
Human   670 HPANEMRIGELHPSLAETPLYPPKLVLLGKDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQAS 734

  Fly   645 AESLS--VIVVRFRHLGTDVDH-------LIRELKQSVRKKP---------------QPVSLPLS 685
            :.|.:  |.|...:....|..|       :.....|.:..||               :|..||:|
Human   735 SGSSNTRVKVGSLQTTAKDAVHNSLWGNRIAPSFPQPLDSKPLLSQREAVPPGNIPQRPDRLPMS 799

  Fly   686 ---------------SGSVCKRTCCDRSNACRHRAIEQEPLAGRSSPSGQSD--RDLLAKDKDDE 733
                           :|.|.:.|..:.:|:        .||....|.|..|.  |.|:.:|    
Human   800 DTFTDNWTDGSHYDNTGFVAEETTAENANS--------NPLLSSKSRSTSSHGRRPLIRQD---- 852

  Fly   734 FVLAHARVLQEEQQLEMLDETESVSESVLSEEQFKCWEYMLEQNTQLLFDKELNTISKSFTKQRT 798
                  |::....:||......:....|.....::.|     ..|...|:......||..|...|
Human   853 ------RIVGVPLELEQSTHRHTPETEVPPSNPWQNW-----TRTPSPFEDRTAFPSKLETTPTT 906

  Fly   799 VPNAIMAATVLPERNDFTSNLMRTVTNKFISTSTPQLPQPITTSVPLGSYHQVKQAPPGHFGSAL 863
            .|        ||||.:            .|..|| ::|.|.:..|| ..||   .:.|..   :|
Human   907 SP--------LPERKE------------HIKEST-EIPSPFSPGVP-WEYH---DSNPNR---SL 943

  Fly   864 S--FQQAHSYGYNLFDAKPRPKFHGGTVKRSAGPNSAYFGSLQRLMP 908
            |  |.|.|.          ||:...|.:..|.        |.:||.|
Human   944 SNVFSQIHC----------RPESSKGVISISK--------STERLSP 972

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380 7/21 (33%)
LRR_8 109..169 CDD:290566 23/59 (39%)
leucine-rich repeat 111..135 CDD:275380 8/23 (35%)
leucine-rich repeat 136..158 CDD:275380 7/21 (33%)
leucine-rich repeat 159..183 CDD:275380 6/23 (26%)
leucine-rich repeat 184..209 CDD:275380 3/24 (13%)
LRR_8 205..266 CDD:290566 21/63 (33%)
leucine-rich repeat 210..230 CDD:275380 9/22 (41%)
leucine-rich repeat 232..255 CDD:275380 7/22 (32%)
LRR_RI <256..410 CDD:238064 49/199 (25%)
leucine-rich repeat 256..276 CDD:275380 6/19 (32%)
LRR_8 279..359 CDD:290566 30/102 (29%)
leucine-rich repeat 280..303 CDD:275380 7/44 (16%)
leucine-rich repeat 304..348 CDD:275380 19/44 (43%)
leucine-rich repeat 349..372 CDD:275380 8/44 (18%)
PP2Cc 461..655 CDD:294085 41/280 (15%)
LRRC7NP_001357714.1 leucine-rich repeat 64..85 CDD:275380 7/20 (35%)
LRR_8 85..140 CDD:338972 20/56 (36%)
leucine-rich repeat 86..108 CDD:275380 7/21 (33%)
leucine-rich repeat 109..131 CDD:275380 7/21 (33%)
LRR 130..440 CDD:227223 91/350 (26%)
leucine-rich repeat 132..177 CDD:275380 18/74 (24%)
leucine-rich repeat 178..200 CDD:275380 9/23 (39%)
leucine-rich repeat 201..223 CDD:275380 7/22 (32%)
leucine-rich repeat 224..246 CDD:275380 6/22 (27%)
leucine-rich repeat 247..269 CDD:275380 7/21 (33%)
leucine-rich repeat 270..292 CDD:275380 0/21 (0%)
leucine-rich repeat 316..336 CDD:275380 5/19 (26%)
leucine-rich repeat 339..361 CDD:275380 5/21 (24%)
leucine-rich repeat 362..384 CDD:275380 3/21 (14%)
leucine-rich repeat 385..407 CDD:275380 5/25 (20%)
leucine-rich repeat 408..430 CDD:275380 7/24 (29%)
PDZ_signaling 1485..1570 CDD:238492
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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