DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and LRFN2

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_065788.1	Gene:	LRFN2 / 57497	HGNCID:	21226	Length:	789	Species:	Homo sapiens

Alignment Length:	651	Identity:	131/651 - (20%)
Similarity:	219/651 - (33%)	Gaps:	201/651 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 QLGGSILI-------GNYNYLTQLEVCENEMEVLDLSSLAQLETLK---CSRNKLMEL---IING 108
            :|||:.:|       .|...|..|.:..|.:..:...|...||:|:   ...|:|..|   .:.|
Human    58 RLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRG 122

  Fly   109 -TNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNW--VGACASLTAINASHNRLN 170
             .|||.|:.::|.|..|:........|.|:.:|:|:||...|| |  |....:|..::..||.|:
Human   123 LVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLP-WDSVRRMVNLHQLSLDHNLLD 186

  Fly   171 NVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSL-PDNFFAVTHARLET 234
            ::|              :..:.||::|.:          |.|.||.|..| ||..||.:.|
Human   187 HIA--------------EGTFADLQKLAR----------LDLTSNRLQKLPPDPIFARSQA---- 223

  Fly   235 LNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLH-NAAKLRVLHLAYNRIGVLPAACV 298
                 :.|:..|      .|..::.|..||        ||| |...|.:..|..:
Human   224 -----SALTATP------FAPPLSFSFGGN--------PLHCNCELLWLRRLERD---------- 259

  Fly   299 RNWPELEIL----VLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHL 359
               .:||..    .|.|.....:.||.               .:|.|.|.         ..|.|
Human   260 ---DDLETCGSPGGLKGRYFWHVREEE---------------FVCEPPLI---------TQHTH- 296

  Fly   360 DRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQR-HWSLVD---VSGNNRAALPTTKI 420
                          |.|.|.|    |....:.|.....|.. ||...|   |..::|.|:.....
Human   297 --------------KLLVLEG----QAATLKCKAIGDPSPLIHWVAPDDRLVGNSSRTAVYDNGT 343

  Fly   421 RQVSAQRNQNKTSGPWTMGFAETPGSGDCR-KLSVYQL---------------RAANYGGSDEAL 469
            ..:....:|:  ||.:|...|...|..... ::|:.||               |.::..||.:..
Human   344 LDIFITTSQD--SGAFTCIAANAAGEATAMVEVSIVQLPHLSNSTSRTAPPKSRLSDITGSSKTS 406

  Fly   470 YGMFEALEGRG-------RAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAA 527
            .|      |.|       ::..|.:.||.::.....:||.|..:...:..:...|..|..  ...
Human   407 RG------GGGSGGGEPPKSPPERAVLVSEVTTTSALVKWSVSKSAPRVKMYQLQYNCSD--DEV 463

  Fly   528 LFHLTRTRAPSKVRPLKSKRYVL-RMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHVL 591
            |.:        ::.|..:|.:|: .:.|..|.|..::                    :|.|....
Human   464 LIY--------RMIPASNKAFVVNNLVSGTGYDLCVL--------------------AMWDDTAT 500

  Fly   592 ELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFR 656
            .|..:|     :||.||.::..|..    :.:...:.:|....::.|.....|...:.::::..|
Human   501 TLTATN-----IVGCAQFFTKADYP----QCQSMHSQILGGTMILVIGGIIVATLLVFIVILMVR 556

  Fly   657 H 657
            :
Human   557 Y 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	7/25 (28%)
		LRR_8	109..169	CDD:290566	20/61 (33%)
		leucine-rich repeat	111..135	CDD:275380	6/23 (26%)
		leucine-rich repeat	136..158	CDD:275380	9/23 (39%)
		leucine-rich repeat	159..183	CDD:275380	5/23 (22%)
		leucine-rich repeat	184..209	CDD:275380	3/24 (13%)
		LRR_8	205..266	CDD:290566	17/61 (28%)
		leucine-rich repeat	210..230	CDD:275380	10/20 (50%)
		leucine-rich repeat	232..255	CDD:275380	2/22 (9%)
		LRR_RI	<256..410	CDD:238064	31/162 (19%)
		leucine-rich repeat	256..276	CDD:275380	6/20 (30%)
		LRR_8	279..359	CDD:290566	12/83 (14%)
		leucine-rich repeat	280..303	CDD:275380	2/22 (9%)
		leucine-rich repeat	304..348	CDD:275380	9/47 (19%)
		leucine-rich repeat	349..372	CDD:275380	2/22 (9%)
		PP2Cc	461..655	CDD:294085	32/201 (16%)
LRFN2	NP_065788.1	LRR 1	53..74		4/15 (27%)
		leucine-rich repeat	54..77	CDD:275380	5/18 (28%)
		LRR_8	76..136	CDD:316378	16/59 (27%)
		LRR 2	77..98		4/20 (20%)
		leucine-rich repeat	78..101	CDD:275380	5/22 (23%)
		LRR 3	101..122		4/20 (20%)
		leucine-rich repeat	102..125	CDD:275380	5/22 (23%)
		LRR_8	125..185	CDD:316378	20/60 (33%)
		LRR 4	125..146		7/20 (35%)
		leucine-rich repeat	126..150	CDD:275380	6/23 (26%)
		LRR 5	150..171		9/21 (43%)
		leucine-rich repeat	151..174	CDD:275380	9/23 (39%)
		LRR_8	174..>215	CDD:316378	14/64 (22%)
		LRR 6	174..195		5/34 (15%)
		leucine-rich repeat	175..198	CDD:275380	7/36 (19%)
		LRR 7	198..219		9/30 (30%)
		LRRCT	242..286	CDD:214507	13/79 (16%)
		Ig	303..376	CDD:325142	16/78 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..424		6/46 (13%)
		fn3	420..493	CDD:306538	15/102 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..602
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	619..654
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	668..702
		PDZ-binding	786..789
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910