DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and CG34357

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001356914.1	Gene:	CG34357 / 5740349	FlyBaseID:	FBgn0085386	Length:	1689	Species:	Drosophila melanogaster

Alignment Length:	653	Identity:	112/653 - (17%)
Similarity:	198/653 - (30%)	Gaps:	216/653 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   446 SGDCRKLSVYQLRAANYGGSDEALYGMFEAL-EGRGRAAQEMSHLVPDLM--KQEQMVKDSAVRD 507
            :||     :.||:..|..||.|......:.| ...|...:.::.|:..|.  .:..||.|...|.
  Fly   786 NGD-----LVQLKEVNINGSAELRTKAMDLLVMAHGLRHENINPLIGWLSDPNRTAMVFDYCSRG 845

  Fly   508 YMKFTLLAAQQQCG-SVRSAALFHLTRTRAPSKVRPLK------------SKRYVLRMASTGGLD 559
            .::..|:..:.:.. |.|.:.|..|.|........||:            ..|:||::... ||:
  Fly   846 SLQDVLIMDEIKLDWSFRLSLLTDLVRGMRYLHTSPLRVHGALTSRNCVVDARWVLKITDY-GLN 909

  Fly   560 AYL--------IRRTSQLRLTKPDVIQKDQIHSMPDPH-----------------VLELILSNDD 599
            ::.        .|...:|..|.|::::..::|.....|                 :::.::...:
  Fly   910 SFYESQGLPPRTRSAKELLWTAPELLRNMKLHQHHHQHGRIQLGTQLGDVYSFGIIMQEVVVRGE 974

  Fly   600 EYLVVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAE-----SLSVIVVRFRHL- 658
            .|.::..:....::.|.:....||...:...|....::|.:...|.:     ..:.:..||:.|
  Fly   975 PYCMLSLSPEEIIVKIKKPPPLIRPSVSKGAAPPEAINIMRQCWAEQPDMRPDFNSVYERFKMLN 1039

  Fly   659 ------------------GTDVDHLIRELKQSV---RKKPQPV---SLPLSSGSVCKRTCCDRSN 699
                              ..:::.||||..:.:   |||.:.:   .||.|.....|...
  Fly  1040 HGRKVNFVDTMFQMLEKYSNNLEELIRERTEQLDIERKKTEQLLNRMLPSSVAEKLKMGL----- 1099

  Fly   700 ACRHRAIEQE----------------PLAGRSSPSGQSD--RDLL--------------AKDKDD 732
                 |::.|                .:|...||....|  .||.              .:...|
  Fly  1100 -----AVDPEEFSDVTIYFSDIVGFTTIAAHCSPVQVVDLLNDLYTIFDATINAYNVYKVETIGD 1159

  Fly   733 EFVLA---------HARVLQEEQQLEMLDET---------------------------------- 754
            .:::.         ||..: ....|::|.::
  Fly  1160 AYMVVSGLPVKIPDHAEQI-ATMALDLLHQSGRFNVKHLPGVPLQLRIGLHTGPCCAGVVGLTMP 1223

  Fly   755 ------ESVSESVLSEEQFKCWEYMLEQNTQLLFDKE------------------LNTI----SK 791
                  ::|:.:...|.....|...:.|.|:...|..                  :||.    .|
  Fly  1224 RYCLFGDTVNTASRMESTGSSWRIHMSQETRDRLDARGGYAIEPRGLIDIKGKGMMNTFWLLGKK 1288

  Fly   792 SFTKQRTVPNAIMAATVLPE---RNDFT----SNLMRTVTNKFISTSTPQLPQPITTSVPLGSYH 849
            .|.|....|..|..:..|.|   ||..|    :|..||.||...|.|:....:.:...|.:
  Fly  1289 GFDKPLPAPPPIGESHGLDESLIRNSITLKAQANKSRTSTNPSSSQSSSLAGESVEVKVEI---- 1349

  Fly   850 QVKQAPPGHFGSALSFQQAHSYGYNLF-------DAKPRPKFHGGTVKRSAGPNSAYFGSLQRLM 907
                .||.:...|......:||..:..       :|...|:|.|.|...|..|.|.   .|..|.
  Fly  1350 ----TPPTNADLASGTNLPNSYSLDSNSTNTISPNATLCPEFPGKTTPSSTSPQSR---KLSELT 1407

  Fly   908 PYN 910
            |.|
  Fly  1408 PEN 1410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380
		leucine-rich repeat	184..209	CDD:275380
		LRR_8	205..266	CDD:290566
		leucine-rich repeat	210..230	CDD:275380
		leucine-rich repeat	232..255	CDD:275380
		LRR_RI	<256..410	CDD:238064
		leucine-rich repeat	256..276	CDD:275380
		LRR_8	279..359	CDD:290566
		leucine-rich repeat	280..303	CDD:275380
		leucine-rich repeat	304..348	CDD:275380
		leucine-rich repeat	349..372	CDD:275380
		PP2Cc	461..655	CDD:294085	38/239 (16%)
CG34357	NP_001356914.1	PKc_like	763..1041	CDD:354810	45/260 (17%)
CG34357	NP_001356914.1	CYCc	1074..1266	CDD:214485	26/202 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900