DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and adcy3a

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_009290286.1	Gene:	adcy3a / 571825	ZFINID:	ZDB-GENE-111027-6	Length:	1119	Species:	Danio rerio

Alignment Length:	192	Identity:	37/192 - (19%)
Similarity:	69/192 - (35%)	Gaps:	50/192 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   638 IAQSFAAAESLSVIVVRFRHLGTDVDHLIREL---KQSVRKKPQPVSLPLSSGSVCKRTCCDRSN 699
            :...:..:..:.:::|.|.:....|:.|.|.|   |..|.::.:.|..            ..|.|
Zfish   811 VPSKYTMSVMIFIMMVSFYYFSRHVEKLARTLFLWKIEVHEQKEKVYE------------MRRWN 863

  Fly   700 ACRHRAIEQEPLAGRSSPSGQSDRDLLAKDKDDEFVL-----AHARVLQEE-------QQLEMLD 752
            ......:..|.:|.....|.:.|.:|.::..|:..|:     ..:....||       :.|..|:
Zfish   864 EALVTNMLPEHVARHFLGSKKRDEELYSQSYDEIGVMFASIPNFSDFYTEESINNGGIECLRFLN 928

  Fly   753 ETESVSESVLSEEQFKCWEYMLEQNTQLLFDKELNTISKSFTKQRTVPNAIMAATVLPERND 814
            |..|..:|:|.|.||:|                       .||.:|:.:..|||:.:...|:
Zfish   929 EIISDFDSLLDEPQFRC-----------------------ITKIKTIGSTYMAASGVTSDNN 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380
		leucine-rich repeat	184..209	CDD:275380
		LRR_8	205..266	CDD:290566
		leucine-rich repeat	210..230	CDD:275380
		leucine-rich repeat	232..255	CDD:275380
		LRR_RI	<256..410	CDD:238064
		leucine-rich repeat	256..276	CDD:275380
		LRR_8	279..359	CDD:290566
		leucine-rich repeat	280..303	CDD:275380
		leucine-rich repeat	304..348	CDD:275380
		leucine-rich repeat	349..372	CDD:275380
		PP2Cc	461..655	CDD:294085	1/16 (6%)
adcy3a	XP_009290286.1	AC_N	<37..304	CDD:292831
		CYCc	273..468	CDD:214485
		Guanylate_cyc	310..492	CDD:278633
		CYCc	858..1075	CDD:214485	28/145 (19%)
		Guanylate_cyc	889..1096	CDD:278633	22/102 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900