DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and adcy6a

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_017209219.1	Gene:	adcy6a / 570652	ZFINID:	ZDB-GENE-060221-1	Length:	1203	Species:	Danio rerio

Alignment Length:	722	Identity:	118/722 - (16%)
Similarity:	229/722 - (31%)	Gaps:	226/722 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 PDNFFA----VTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAK-- 279
            ||..:|    |..|....|.|.||:..    :.| ::..:|:..:.|..:...:|..|..|.:
Zfish   203 PDVVYASVLSVAMALFLALMVVCNRNG----FHQ-DYMWMVSYLVIGVLIIVQVFGVLMVAPRSA 262

  Fly   280 -------LRVLHLAYNRIGVLPAACVRNWPELEILVLSGNML-------------------QQLP 318
                   :..:::.|.   :||.       .:...||||.:|                   :||.
Zfish   263 SEGIWWSVFFIYIIYT---LLPV-------RMRAAVLSGGVLSAIHLLTTWRINQDDEFLWKQLS 317

  Fly   319 EEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHN------HLDRVN------LLALVPSR 371
            ..|.      :..|.|.:.:||...|:::..:....:..      ||.|.|      ||:::| |
Zfish   318 ANVL------IFLCTNIIGICTHYPAEVSQRQAFQETRGYIQARLHLQRENQQQERLLLSVLP-R 375

  Fly   372 NLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLV--DVSGNNRAALPTTKIRQVSAQRNQNKTSG 434
            ::. :::..::..:.::..|.....|...:.|::  |:.|.      |:...|.:|| ....|..
Zfish   376 HVA-MEMKADINAKKEDMMFHKIYIQKHDNVSILFADIEGF------TSLASQCTAQ-ELVMTLN 432

  Fly   435 PWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQM 499
            .....|.:......|.::.:       .|.....:.|:.|..........||.   .|:::...:
Zfish   433 ELFARFDKLASENHCLRIKI-------LGDCYYCVSGLPEPRADHAHCCVEMG---VDMIEAISL 487

  Fly   500 VKD-SAVRDYMKFTLLAAQQQCGSV-----------------------RSAALFHLTRT-----R 535
            |:: :.|...|:..:.:.:..||.:                       ..|...|:|:.     .
Zfish   488 VREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLQYLN 552

  Fly   536 APSKVRP---------LKSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHVL 591
            ...:|.|         ||.          ..::.:|:...||.|..:..::.|           :
Zfish   553 GDYEVEPGFGGERNAYLKE----------NSIETFLVLGCSQKRKDEKAMMAK-----------M 596

  Fly   592 ELILSNDDEYLV-----------VGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAA 645
            :...:|.:|.||           ..:::::..|.||..:.:..:.....|..:..||
Zfish   597 QRTRTNSNEALVPRWVPDRSFSRTKDSKVFRQMGIDETSSKDNRGAQEALNPEDEVD-------- 653

  Fly   646 ESLSVIVVRFRHLGTDVDHLIRELKQSVRKKPQPVSLPLSSGSVCKRTCCDRSNACRHRAIEQEP 710
                      ..||..:|  .|.:.|..:...:...|...:.|:.|:
Zfish   654 ----------EFLGRAID--ARSIDQLRKDHVKKFLLTFQTSSLEKK------------------ 688

  Fly   711 LAGRSSPSGQSDRDLLAKDKDDEF------------VLAHARVLQEEQQLEMLDETESVSESVLS 763
                           .||..||.|            .::..:::.....|.||....|:. .:|:
Zfish   689 ---------------YAKKVDDRFGGYVACTLLVFCFISFIQIVVFPHTLVMLGIYISIF-IILA 737

  Fly   764 EEQFKCWEYMLEQNTQLLFDKELNTISKSFTKQRTVPNAIMAATVLPERNDFTSNLMRTVTNKFI 828
            ...|.|..|...:    ||...:.|:||...:.||....:...|::........|:....|.|.:
Zfish   738 NILFICAIYSCVK----LFPAAMQTVSKKIVQSRTNSTLVGVFTIILVFISAFVNMFSCDTQKLV 798

  Fly   829 STSTPQL 835
            .....||
Zfish   799 DCVAKQL 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380
		leucine-rich repeat	184..209	CDD:275380
		LRR_8	205..266	CDD:290566	12/48 (25%)
		leucine-rich repeat	210..230	CDD:275380	4/12 (33%)
		leucine-rich repeat	232..255	CDD:275380	5/22 (23%)
		LRR_RI	<256..410	CDD:238064	33/195 (17%)
		leucine-rich repeat	256..276	CDD:275380	4/19 (21%)
		LRR_8	279..359	CDD:290566	16/113 (14%)
		leucine-rich repeat	280..303	CDD:275380	3/22 (14%)
		leucine-rich repeat	304..348	CDD:275380	13/62 (21%)
		leucine-rich repeat	349..372	CDD:275380	7/34 (21%)
		PP2Cc	461..655	CDD:294085	33/242 (14%)
adcy6a	XP_017209219.1	AC_N	<97..395	CDD:318454	39/214 (18%)
		Guanylate_cyc	397..570	CDD:306677	27/189 (14%)
		DUF1053	609..696	CDD:310728	17/139 (12%)
		Guanylate_cyc	1004..1197	CDD:306677
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900