DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and npr3

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_005165413.1	Gene:	npr3 / 569395	ZFINID:	ZDB-GENE-060531-91	Length:	503	Species:	Danio rerio

Alignment Length:	232	Identity:	43/232 - (18%)
Similarity:	82/232 - (35%)	Gaps:	61/232 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LIGNYNYLTQLEVCENEMEVLD----LSSLAQLE-TLKCSRNKLMELIINGTNLQTLVADHNYLH 122
            ::..|:..|...|..:..|.:|    ::|:...| .:.||:..::..::...:.:.|.:|.:...
Zfish   190 VLSEYHISTDFAVLNSNEERVDPDGIITSVYGSEVVIMCSKADIVRDLMLAAHRRKLTSDSHIFF 254

  Fly   123 NISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSL 187
            ||...|:.           |:.:.|    |...........|:::.||.|.:|    |.|:
Zfish   255 NIELFNSS-----------SYGDGS----WRRRDKYDDEARAAYSFLNTVTLL----RSTK---- 296

  Fly   188 DLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNN 252
                      .:| |.||......||.:.:|                   .|...|.:..:.:..
Zfish   297 ----------PEF-EDFSIEMKKSLQQSNIP-------------------ICEDCSAVNMFMEGF 331

  Fly   253 HAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNR 289
            |.||:..::|   |.:...:.|.....|.:.|..:||
Zfish   332 HDALLLYAIA---LREVKSKGLTKKNGLEITHSMWNR 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	3/19 (16%)
		LRR_8	109..169	CDD:290566	9/59 (15%)
		leucine-rich repeat	111..135	CDD:275380	5/23 (22%)
		leucine-rich repeat	136..158	CDD:275380	3/21 (14%)
		leucine-rich repeat	159..183	CDD:275380	6/23 (26%)
		leucine-rich repeat	184..209	CDD:275380	4/24 (17%)
		LRR_8	205..266	CDD:290566	10/60 (17%)
		leucine-rich repeat	210..230	CDD:275380	3/19 (16%)
		leucine-rich repeat	232..255	CDD:275380	3/22 (14%)
		LRR_RI	<256..410	CDD:238064	8/34 (24%)
		leucine-rich repeat	256..276	CDD:275380	4/19 (21%)
		LRR_8	279..359	CDD:290566	4/11 (36%)
		leucine-rich repeat	280..303	CDD:275380	4/10 (40%)
		leucine-rich repeat	304..348	CDD:275380
		leucine-rich repeat	349..372	CDD:275380
		PP2Cc	461..655	CDD:294085
npr3	XP_005165413.1	Periplasmic_Binding_Protein_Type_1	29..416	CDD:299141	43/232 (19%)
		ANF_receptor	46..389	CDD:279440	43/232 (19%)
		TM_EphA1	436..468	CDD:214014
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900