DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and si:dkey-1h4.4

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_021333533.1	Gene:	si:dkey-1h4.4 / 566734	ZFINID:	ZDB-GENE-160728-41	Length:	251	Species:	Danio rerio

Alignment Length:	256	Identity:	69/256 - (26%)
Similarity:	115/256 - (44%)	Gaps:	36/256 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 LEVCENEMEVLDLS---------SLAQLETLKCSRNKLMELIINGTNLQTLVADHNYLHNISTTN 128
            ||....:.|.|::|         .:::|.|||       :|.:|  |.|.::.....||
Zfish     8 LECFNKQQESLNMSHRGLVVLPPGVSRLVTLK-------KLFLN--NNQLILPPDEILH------ 57

  Fly   129 THPVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYND 193
                ..||:.:.:..|..:.||:.:|:...||.:..:||.|:.:...|.:  :|||..|......
Zfish    58 ----LEKLEELILDRNQLTMLPSNIGSLKHLTYLGINHNPLSVLPEALGD--LTELRELWAVGCG 116

  Fly   194 LKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNH-AALV 257
            |..|.......|.::.|.:.:|.:.:||..|.::::  |:.||::.|||..||  |..|| .:||
Zfish   117 LISLPSSIGKLSKLQKLGVHNNIITNLPSQFGSLSN--LQWLNLADNKLQDLP--EDINHLPSLV 177

  Fly   258 NLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLP 318
            .::|..|...| |...|.:.|.|::|.|.:|.|..|....:..:..|..|.:..|.|...|
Zfish   178 FINLDKNCFTD-IPTVLTDMANLQILSLKFNSIRTLEDYLIPGFSRLTKLDIRENPLMDRP 237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	6/18 (33%)
		LRR_8	109..169	CDD:290566	14/59 (24%)
		leucine-rich repeat	111..135	CDD:275380	3/23 (13%)
		leucine-rich repeat	136..158	CDD:275380	5/21 (24%)
		leucine-rich repeat	159..183	CDD:275380	6/23 (26%)
		leucine-rich repeat	184..209	CDD:275380	5/24 (21%)
		LRR_8	205..266	CDD:290566	21/61 (34%)
		leucine-rich repeat	210..230	CDD:275380	5/19 (26%)
		leucine-rich repeat	232..255	CDD:275380	11/23 (48%)
		LRR_RI	<256..410	CDD:238064	19/63 (30%)
		leucine-rich repeat	256..276	CDD:275380	7/19 (37%)
		LRR_8	279..359	CDD:290566	11/40 (28%)
		leucine-rich repeat	280..303	CDD:275380	6/22 (27%)
		leucine-rich repeat	304..348	CDD:275380	5/15 (33%)
		leucine-rich repeat	349..372	CDD:275380
		PP2Cc	461..655	CDD:294085
si:dkey-1h4.4	XP_021333533.1	leucine-rich repeat	16..34	CDD:275380	3/17 (18%)
		LRR	<32..>238	CDD:227223	64/232 (28%)
		leucine-rich repeat	38..60	CDD:275380	8/40 (20%)
		leucine-rich repeat	61..83	CDD:275380	5/21 (24%)
		leucine-rich repeat	84..106	CDD:275380	6/23 (26%)
		leucine-rich repeat	107..129	CDD:275380	4/21 (19%)
		leucine-rich repeat	130..152	CDD:275380	5/21 (24%)
		leucine-rich repeat	153..175	CDD:275380	11/23 (48%)
		leucine-rich repeat	176..198	CDD:275380	7/22 (32%)
		leucine-rich repeat	199..222	CDD:275380	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45752
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100