DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and lrrc7

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_005166019.1	Gene:	lrrc7 / 566023	ZFINID:	ZDB-GENE-130530-876	Length:	1556	Species:	Danio rerio

Alignment Length:	924	Identity:	215/924 - (23%)
Similarity:	332/924 - (35%)	Gaps:	255/924 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 ENEMEVLDLS--SLAQ-----------LETLKCSRNKLMEL---IINGTNLQTLVADHNYLHNIS 125
            |..:.|||.|  ||.|           ||.|....|::.||   :.|...|:.|....|.|.|:.
Zfish    34 EEVISVLDYSHCSLQQVPKEIFSFERTLEELYLDANQIEELPKQLFNCQALKKLSMPDNDLSNLP 98

  Fly   126 TTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLDLA 190
            ||....|.||  .:|||.|...|.|:.:..|..|:.:.||   :|.:|.|...:  |:|::|...
Zfish    99 TTIASLVNLK--ELDISKNGIQEFPDNIKCCKCLSVVEAS---VNPIAKLPEGF--TQLLNLTQL 156

  Fly   191 YNDLKQLDQFPEGF---SSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNN 252
            :.:...|:..|..|   |.:|.|:|:.|.|.::|.:...:  ::||.|::..|:.|.||...:..
Zfish   157 FLNDAFLEYLPANFGRLSKLRILELRENHLKTMPKSIHRL--SQLERLDLGSNEFSELPEVLEQI 219

  Fly   253 HAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQL 317
            | :|..|.|..|.| .:|...:....:||.|.||.|||..|.|. :.....||.|:||.||||||
Zfish   220 H-SLKELWLDNNSL-QTIPGSIGKLRQLRYLDLAKNRIESLDAD-ISGCESLEDLLLSANMLQQL 281

  Fly   318 PEEVATLGQLRVLRCCNNLLLCTPQLA-------KLAMLKVLDLSHNHLDRV------------- 362
            |:.:..|.:|..|:..:|.|...|...       .|::|:..|.|.|.|:.:
Zfish   282 PDSIGKLKKLTTLKVDDNQLTSLPNTIGSAHGKFGLSLLEEFDCSCNELESLPPTIGYLHSLRTF 346

  Fly   363 ----NLLALVP-----SRNLKYLDLSGN-LQLQVDE--QQFKVCQSQSQRHWSLVDVSGNNRAAL 415
                |.|:.:|     .||:..:.|..| |:...||  |..|:         .::::|.|....|
Zfish   347 AADENFLSDLPREIGNCRNVTVMSLRSNKLEFLPDEIGQMTKL---------RVLNLSDNRLKNL 402

  Fly   416 P--TTKIRQVSA---QRNQNKTSGP-WTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFE 474
            |  .||::.::|   ..||:|...| .|....||.           |....||         ||.
Zfish   403 PFTFTKLKDLAALWLSDNQSKALIPLQTEAHPETK-----------QRVLTNY---------MFP 447

  Fly   475 ALEGRGRAAQ-EMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAALFHLTRTRAPS 538
            .........| :.....|.|.::::..:.:...::..    ..:::..|.:.....:|.|...|
Zfish   448 QQPRHDEDYQSDTDSFNPTLWEEQRQQRMTVAFEFED----KKEEEDNSGKVKVEINLKRYPTP- 507

  Fly   539 KVRPLKSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHVLELILSNDDEYLV 603
              .|...|..|..:.:..|      :.|..|...|.......::||             .|:|
Zfish   508 --YPEDLKNMVKSVQNLVG------KTTHPLNTEKCSSGTNMELHS-------------QDKY-- 549

  Fly   604 VGNAQLWSVMDIDRAAREIRKEENSLLA------------AKRLVDIAQSFAAAESLSVIVVRFR 656
               ...|.:...:...|:::...|..::            .||..|:.:|  :..||..:|.:
Zfish   550 ---EPKWPIAPKEVTERDVKDYSNQPMSDQGVILNSAIDIPKRKEDLTES--SEISLHRVVPK-- 607

  Fly   657 HLGTDVDHLIRELKQSVRKKPQPVSLPLSSGSVCKRTCCDRSNACRHRAIEQEPLAGRSSPSGQS 721
                             .::|:..||.:||.| |  .|...|                   .|.|
Zfish   608 -----------------PQQPENTSLAVSSSS-C--FCLIDS-------------------MGGS 633

  Fly   722 DRDLLAKDKDDEFV----LAHARVLQEEQQLEMLDETESVSESVLSEEQFKCWEYMLEQNTQLLF 782
            ..|:...|.....|    .....||..:::.|..||:|        .::..|
Zfish   634 PNDIRISDMRPTLVEPPMYKPKVVLLGKEKKESTDESE--------PDKMHC------------- 677

  Fly   783 DKELNTISKSFTKQRTVPNAIMAATVLPERNDFTSNLMRTVTNKFISTST-------PQLPQPIT 840
               ||....|.|.....|:...:.:..|..|  ..||.  .:.|..|:.|       ...|:||.
Zfish   678 ---LNNSGSSATYSDYSPSQGSSGSSNPPGN--VGNLQ--TSGKEGSSQTHWTNRLAQSFPKPIE 735

  Fly   841 TSVPLGSYHQVKQAPPGHFGSAL--------------SFQQAHSYGYNLFDAKPRPKFHGGTVKR 891
            |. ||.|.   ::.||   .|.|              |:..|..|....|.|:..|.   .|...
Zfish   736 TK-PLLSQ---RETPP---SSTLQQRGERRPLSDTFDSWNDAPHYDNTGFVAEEMPL---DTPSS 790

  Fly   892 SAG-------PNSA 898
            |||       |.||
Zfish   791 SAGNPMLGSKPRSA 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	7/21 (33%)
		LRR_8	109..169	CDD:290566	20/59 (34%)
		leucine-rich repeat	111..135	CDD:275380	8/23 (35%)
		leucine-rich repeat	136..158	CDD:275380	7/21 (33%)
		leucine-rich repeat	159..183	CDD:275380	6/23 (26%)
		leucine-rich repeat	184..209	CDD:275380	6/27 (22%)
		LRR_8	205..266	CDD:290566	19/60 (32%)
		leucine-rich repeat	210..230	CDD:275380	5/19 (26%)
		leucine-rich repeat	232..255	CDD:275380	8/22 (36%)
		LRR_RI	<256..410	CDD:238064	53/185 (29%)
		leucine-rich repeat	256..276	CDD:275380	6/19 (32%)
		LRR_8	279..359	CDD:290566	33/86 (38%)
		leucine-rich repeat	280..303	CDD:275380	10/22 (45%)
		leucine-rich repeat	304..348	CDD:275380	19/50 (38%)
		leucine-rich repeat	349..372	CDD:275380	8/44 (18%)
		PP2Cc	461..655	CDD:294085	32/206 (16%)
lrrc7	XP_005166019.1	LRR_RI	<37..269	CDD:238064	74/243 (30%)
		leucine-rich repeat	39..60	CDD:275380	7/20 (35%)
		LRR_8	59..117	CDD:290566	21/59 (36%)
		leucine-rich repeat	61..83	CDD:275380	7/21 (33%)
		leucine-rich repeat	84..106	CDD:275380	7/21 (33%)
		leucine-rich repeat	107..152	CDD:275380	17/51 (33%)
		leucine-rich repeat	153..175	CDD:275380	4/21 (19%)
		LRR_8	174..232	CDD:290566	19/60 (32%)
		leucine-rich repeat	176..198	CDD:275380	6/23 (26%)
		leucine-rich repeat	199..221	CDD:275380	8/22 (36%)
		LRR_8	221..278	CDD:290566	22/58 (38%)
		leucine-rich repeat	222..244	CDD:275380	6/22 (27%)
		leucine-rich repeat	245..267	CDD:275380	10/22 (45%)
		LRR_4	266..306	CDD:289563	17/39 (44%)
		leucine-rich repeat	291..319	CDD:275380	6/27 (22%)
		leucine-rich repeat	343..365	CDD:275380	3/21 (14%)
		LRR_8	364..421	CDD:290566	16/65 (25%)
		LRR_4	365..403	CDD:289563	10/46 (22%)
		leucine-rich repeat	366..388	CDD:275380	6/21 (29%)
		LRR_4	387..429	CDD:289563	12/50 (24%)
		leucine-rich repeat	389..411	CDD:275380	6/30 (20%)
		PDZ_signaling	1468..1551	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910