DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and Shoc2

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001161977.1	Gene:	Shoc2 / 56392	MGIID:	1927197	Length:	582	Species:	Mus musculus

Alignment Length:	593	Identity:	136/593 - (22%)
Similarity:	214/593 - (36%)	Gaps:	182/593 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KQADPYKSKLKVSASHSG-----------PHPLP------------VEVTAAEEEQAATFGQTSP 48
            |..|....|.:.||:..|           |:|.|            .|:....||.:
Mouse    46 KGKDAKDGKKESSAAQPGVAFSVDNTIKRPNPAPGTRKKSSNAEVIKELNKCREENS-------- 102

  Fly    49 QKLSLKGSQLGGSIL---IGNYNYLTQLEVCENEMEVL--DLSSLAQLETLKCSRNKLMEL---I 105
            .:|.|  |:....||   :.....||:|.:..|:::.|  ::..|..|.||..|.|.|..|   :
Mouse   103 MRLDL--SKRSIHILPPSVKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSL 165

  Fly   106 INGTNLQTLVADHNYLHNI--------STTNTH--------------PVPLKLQRIDISHNNFSE 148
            .|...|:.|...||.|..|        |.|..:              .:| ||..:.|..|...:
Mouse   166 DNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLP-KLSMLSIRENKIKQ 229

  Fly   149 LPNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQ 213
            ||..:|...:|..::.:||:|.::...:.|  .|::.:|||.:|||..|.......||:..|.|:
Mouse   230 LPAEIGELCNLITLDVAHNQLEHLPKEIGN--CTQITNLDLQHNDLLDLPDTIGNLSSLNRLGLR 292

  Fly   214 SNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHL------NDSIFE 272
            .|.|.::|.:.  ...:.||.||:..|.:||||....::...|.:|:||.|..      ..|.|.
Mouse   293 YNRLSAIPRSL--AKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFS 355

  Fly   273 PLHNAAKLRVLHLAYNRIGVLPAACVR-----------------------NWPELEILVLSGNML 314
            .:::      |::.:|||..:|.....                       .|..:..|.|:.|.|
Mouse   356 TIYS------LNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQL 414

  Fly   315 QQLPEEVATLGQLRVLRCCNNLLLCTPQ-LAKLAMLKVLDLSHNHLDRV---------------- 362
            .::||:|:.|..|.||...||||...|. |..|..|:.|||..|.|:.:
Mouse   415 TKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLT 479

  Fly   363 -NLLALVPS-----RNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIR 421
             |.|:.:|.     .||.:|.|..||...:.|:               :....|         :.
Mouse   480 NNQLSTLPRGIGHLTNLTHLGLGENLLTHLPEE---------------IGTLEN---------LE 520

  Fly   422 QVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEM 486
            ::....|.|..|.|:.:..        |.|||:..:...                        .:
Mouse   521 ELYLNDNPNLHSLPFELAL--------CSKLSIMSIENC------------------------PL 553

  Fly   487 SHLVPDLM 494
            |||.|.::
Mouse   554 SHLPPQIV 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	8/21 (38%)
		LRR_8	109..169	CDD:290566	19/81 (23%)
		leucine-rich repeat	111..135	CDD:275380	9/45 (20%)
		leucine-rich repeat	136..158	CDD:275380	6/21 (29%)
		leucine-rich repeat	159..183	CDD:275380	5/23 (22%)
		leucine-rich repeat	184..209	CDD:275380	9/24 (38%)
		LRR_8	205..266	CDD:290566	21/60 (35%)
		leucine-rich repeat	210..230	CDD:275380	5/19 (26%)
		leucine-rich repeat	232..255	CDD:275380	9/22 (41%)
		LRR_RI	<256..410	CDD:238064	47/205 (23%)
		leucine-rich repeat	256..276	CDD:275380	7/25 (28%)
		LRR_8	279..359	CDD:290566	29/103 (28%)
		leucine-rich repeat	280..303	CDD:275380	6/45 (13%)
		leucine-rich repeat	304..348	CDD:275380	18/44 (41%)
		leucine-rich repeat	349..372	CDD:275380	9/44 (20%)
		PP2Cc	461..655	CDD:294085	4/34 (12%)
Shoc2	NP_001161977.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..88		9/41 (22%)
		LRR 1	101..122		5/30 (17%)
		leucine-rich repeat	104..124	CDD:275380	5/21 (24%)
		PLN00113	<115..>483	CDD:215061	98/378 (26%)
		LRR 2	124..145		5/20 (25%)
		leucine-rich repeat	125..147	CDD:275380	6/21 (29%)
		LRR 3	147..169		8/21 (38%)
		leucine-rich repeat	148..170	CDD:275380	8/21 (38%)
		LRR 4	170..191		6/20 (30%)
		leucine-rich repeat	171..193	CDD:275380	6/21 (29%)
		LRR 5	193..215		2/21 (10%)
		leucine-rich repeat	194..216	CDD:275380	2/22 (9%)
		LRR 6	216..237		7/20 (35%)
		leucine-rich repeat	217..239	CDD:275380	6/21 (29%)
		LRR 7	239..260		5/22 (23%)
		leucine-rich repeat	240..262	CDD:275380	5/23 (22%)
		LRR 8	262..283		7/20 (35%)
		leucine-rich repeat	263..285	CDD:275380	7/21 (33%)
		LRR 9	285..307		6/23 (26%)
		leucine-rich repeat	286..332	CDD:275380	14/47 (30%)
		LRR 10	308..329		9/20 (45%)
		LRR 11	332..353		5/20 (25%)
		leucine-rich repeat	333..380	CDD:275380	12/52 (23%)
		LRR 12	356..377		5/26 (19%)
		LRR 13	380..400		0/19 (0%)
		leucine-rich repeat	381..403	CDD:275380	1/21 (5%)
		LRR 14	403..424		7/20 (35%)
		leucine-rich repeat	404..426	CDD:275380	8/21 (38%)
		LRR 15	426..448		9/21 (43%)
		leucine-rich repeat	427..449	CDD:275380	10/21 (48%)
		LRR 16	449..470		6/20 (30%)
		leucine-rich repeat	450..472	CDD:275380	6/21 (29%)
		PLN03150	<453..527	CDD:178695	16/97 (16%)
		LRR 17	472..494		3/21 (14%)
		leucine-rich repeat	473..495	CDD:275380	3/21 (14%)
		LRR 18	495..516		7/35 (20%)
		leucine-rich repeat	496..519	CDD:275380	7/46 (15%)
		LRR 19	518..540		5/38 (13%)
		LRR 20	542..563		7/44 (16%)
		leucine-rich repeat	543..563	CDD:275380	6/43 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9772
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940