DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and adcy2a

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:XP_692173.5 Gene:adcy2a / 563724 ZFINID:ZDB-GENE-061109-1 Length:1155 Species:Danio rerio


Alignment Length:295 Identity:55/295 - (18%)
Similarity:101/295 - (34%) Gaps:98/295 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   101 LMELIINGTNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINAS 165
            |||.:.|.:|...|..|           ..|:|.      :..|.| .||.::.:|. |..|:.|
Zfish   766 LMETVYNTSNETLLQPD-----------GQPIPY------LDKNTF-YLPYFIYSCI-LGLISCS 811

  Fly   166 HNRLNNVAVLLR-NYRITELV--------SLDLAYNDLKQLDQFPEGFSSIRSLQLQS-----NE 216
                    |.|| ||.:..|:        |:.:.......||::.:.......::...     ..
Zfish   812 --------VFLRINYELKMLIMLTAVVLYSVIILQTHASLLDEYSKFLYKTEVIERPGVLKDLKT 868

  Fly   217 LPSLPDNFFAVT----------HARLETL-----NVSCNKLSTLPRYEQNNHAALVNL------- 259
            :.|:....|.:|          :.||:.|     ...|.::.|:   |..|...|.|:       
Zfish   869 MGSVSLFIFFITLLVLARQNEYYCRLDFLWKNKFKKECEEIETM---ENLNRVLLENVLPAHVAE 930

  Fly   260 -SLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVAT 323
             .||.|..|:.::            |.:|:.:.|:.|:.    |:.:......::.::       
Zfish   931 HFLARNWKNEDLY------------HQSYDLVCVMFASI----PDFKEFYTESDVNKE------- 972

  Fly   324 LGQLRVLRCCNNL------LLCTPQLAKLAMLKVL 352
              .|..||..|.:      ||..|:.:.:..:|.:
Zfish   973 --GLECLRLLNEIIADFDELLSKPKFSGVEKIKTI 1005

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380 4/8 (50%)
LRR_8 109..169 CDD:290566 13/59 (22%)
leucine-rich repeat 111..135 CDD:275380 4/23 (17%)
leucine-rich repeat 136..158 CDD:275380 5/21 (24%)
leucine-rich repeat 159..183 CDD:275380 8/24 (33%)
leucine-rich repeat 184..209 CDD:275380 4/32 (13%)
LRR_8 205..266 CDD:290566 15/88 (17%)
leucine-rich repeat 210..230 CDD:275380 3/34 (9%)
leucine-rich repeat 232..255 CDD:275380 6/27 (22%)
LRR_RI <256..410 CDD:238064 19/111 (17%)
leucine-rich repeat 256..276 CDD:275380 6/27 (22%)
LRR_8 279..359 CDD:290566 13/80 (16%)
leucine-rich repeat 280..303 CDD:275380 4/22 (18%)
leucine-rich repeat 304..348 CDD:275380 7/49 (14%)
leucine-rich repeat 349..372 CDD:275380 1/4 (25%)
PP2Cc 461..655 CDD:294085
adcy2aXP_692173.5 AC_N <92..319 CDD:292831
CYCc 295..498 CDD:214485
Guanylate_cyc 340..524 CDD:278633
DUF1053 554..658 CDD:283888
CYCc 912..1120 CDD:214485 21/122 (17%)
Guanylate_cyc 942..1141 CDD:278633 13/89 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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