DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and adcy6b

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:XP_002666536.2 Gene:adcy6b / 560807 ZFINID:ZDB-GENE-090127-2 Length:1174 Species:Danio rerio


Alignment Length:628 Identity:103/628 - (16%)
Similarity:200/628 - (31%) Gaps:211/628 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   329 VLRCCNNLLLCTPQLAKLAMLKVLDLSHN------HLDRVN------LLALVPSRNLKYLDLSGN 381
            :..|.|.:.:||...|:::..:....:..      ||.|.|      ||:::| |::. :::..:
Zfish   303 IFLCTNIIGICTHYPAEVSQRQAFKETRGYIQARIHLQRENQQQERLLLSVLP-RHVA-MEMKAD 365

  Fly   382 LQLQVDEQQFKVCQSQSQRHWSLV--DVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETP 444
            :..:.::..|.....|...:.|::  |:.|.      |:...|.:|| ....|.......|.:..
Zfish   366 INAKKEDMMFHKIYIQKHDNVSILFADIEGF------TSLASQCTAQ-ELVMTLNELFARFDKLA 423

  Fly   445 GSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKD-SAVRDY 508
            ....|.::.:       .|.....:.|:.|..........||.   .|:::...:|:: :.|...
Zfish   424 WENHCLRIKI-------LGDCYYCVSGLPEPRADHAHCCVEMG---VDMIEAISLVREVTGVNVN 478

  Fly   509 MKFTLLAAQQQCGSVRSAALFHLTRTRAPSKVRPLKSKRY--------VLRMASTGGLDAYLIRR 565
            |:..:.:.:..||                  |..|:..::        :......||       :
Zfish   479 MRVGIHSGRVHCG------------------VLGLRKWQFDVWSNDVTLANQMEAGG-------K 518

  Fly   566 TSQLRLTKPDVIQKDQIHSMPDPHVLELILSND-DEYLVVGNAQLWSVMDIDRAAREIRKEENSL 629
            ..::.:||.      .:..:...:.:|.....| :.||...|.:.:.|:    ...:.||||.::
Zfish   519 AGRIHITKA------TLQYLNGDYEVEAGFGGDRNAYLNNNNIETFFVL----GCSQKRKEEKAM 573

  Fly   630 LAAKR--------------LVDIAQSFAAAESLSVIVVRFRHLGTDVDHLIRELKQSVRKKPQPV 680
            :|..:              :.|  :||:..:...|    ||.:|.|                   
Zfish   574 MAKMQRARANSSEGLMPRWVPD--RSFSRTKDSKV----FRQMGID------------------- 613

  Fly   681 SLPLSSGSVCKRTCCDRSNACRHRAI----EQEPLAGRSSPSGQSDRDLLAKDKDDEFVLAHARV 741
                        ....:.|.|...|:    |.:...||:..:...|:  |.||...:|:|.....
Zfish   614 ------------EASSKDNRCAQEALNPEDEVDEFLGRAIDARSIDQ--LRKDHVKKFLLTFQTP 664

  Fly   742 LQEEQQLEMLDE-----------------------------------TESVSESVLSEEQFKCWE 771
            |.|::..:.:|:                                   |..:   :|:...|.|..
Zfish   665 LLEKKYSKKVDDRFGGYVACTLLVFCFIVFIQIVIFPHTPLMLGLFITIFI---ILAHVLFICAI 726

  Fly   772 YMLEQNTQLLFDKELNTISKSFTKQRTVPNAIMAATVL------------PERNDFTS------N 818
            |...:    ||...|.|:||...:.|.....:...|:|            .:|.|..:      |
Zfish   727 YSCVK----LFPVTLQTVSKRIVQSRINSTLVGVFTILLLFISAFVNMFTCDRTDMLACVAGHLN 787

  Fly   819 LMRTVT-------------NKFISTSTPQ---LPQPITTSVPL 845
            :..:||             ..|:....|.   ||:..|.||.|
Zfish   788 ISESVTLCLLYNLSGLAEDPFFLCLDQPSACPLPEYFTYSVLL 830

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380
LRR_8 109..169 CDD:290566
leucine-rich repeat 111..135 CDD:275380
leucine-rich repeat 136..158 CDD:275380
leucine-rich repeat 159..183 CDD:275380
leucine-rich repeat 184..209 CDD:275380
LRR_8 205..266 CDD:290566
leucine-rich repeat 210..230 CDD:275380
leucine-rich repeat 232..255 CDD:275380
LRR_RI <256..410 CDD:238064 17/94 (18%)
leucine-rich repeat 256..276 CDD:275380
LRR_8 279..359 CDD:290566 5/35 (14%)
leucine-rich repeat 280..303 CDD:275380
leucine-rich repeat 304..348 CDD:275380 5/18 (28%)
leucine-rich repeat 349..372 CDD:275380 7/34 (21%)
PP2Cc 461..655 CDD:294085 32/217 (15%)
adcy6bXP_002666536.2 AC_N 15..376 CDD:318454 13/74 (18%)
Guanylate_cyc 378..562 CDD:306677 34/235 (14%)
DUF1053 590..677 CDD:310728 23/125 (18%)
Guanylate_cyc 975..1169 CDD:306677
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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