DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and npr1a

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001038402.1	Gene:	npr1a / 560653	ZFINID:	ZDB-GENE-060503-539	Length:	1067	Species:	Danio rerio

Alignment Length:	800	Identity:	139/800 - (17%)
Similarity:	235/800 - (29%)	Gaps:	380/800 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 ENEM---------EVLDLSSLAQLETLKCSRNKLMELIINGTNLQTLVA-DHN---------YLH 122
            |||:         |.:.:|:..::....||:   :.:.:.|:|..:|:. |.|         |..
Zfish   506 ENELTAQLWRVHWEDIQMSNTEKVLRRACSK---LTISLRGSNYGSLLTMDGNFQIYAKTGYYKG 567

  Fly   123 NISTTN---------THPVPLKLQRI-DISHNNFSELPNWVGACASLTAINASHNRLNNVAVL-- 175
            ||:...         |..|..:|:.: |:.:.:   |..::|||....          |:.:|
Zfish   568 NITAIKYVNKKRIELTRKVLFELKHMRDVQNEH---LTRFIGACIDPP----------NICILTE 619

  Fly   176 ------LRNYRITELVSLDLAY-----NDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTH 229
                  |::...:|.::||..:     ||:            ::.:....|.:        .|:|
Zfish   620 YCPRGSLQDLMESEGITLDWMFRYSLINDI------------VKGMAFLHNSV--------IVSH 664

  Fly   230 ARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLP 294
            ..|::.|...:....|                   .:.|...|..|..:.|..:|..|.|
Zfish   665 GNLKSSNCVVDSRFVL-------------------KITDYGLESFHKDSNLDDVHAFYAR----- 705

  Fly   295 AACVRNWPELEIL--------------VLS-GNMLQQL---------------PEEV-------- 321
                :.|...|:|              |.| |.:||:|               |:|:
Zfish   706 ----QLWTAPELLRADNPPACGTQKGDVYSFGIILQELALLKGVFYLEGPCLSPKEIIERVVEGR 766

  Fly   322 --------------ATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRN 372
                          ..:||| :|||.:..:...|..::   :|||...:|.....|:|..:.||.
Zfish   767 WPYLRPLLCPQSHSEEMGQL-MLRCWSEDVNERPDFSQ---IKVLLRKNNCGYGSNILDNLLSRM 827

  Fly   373 LKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWT 437
            .:|   :.||:..|:|:                                               |
Zfish   828 EQY---ANNLEELVEER-----------------------------------------------T 842

  Fly   438 MGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKD 502
            ..:.|     :.||             ::..||             |.:.|.|.:.:|:.:||:.
Zfish   843 QAYHE-----EKRK-------------AEALLY-------------QILPHSVAEQLKRGEMVQA 876

  Fly   503 SA-------VRDYMKFTLLAAQQQCGSVRSAALFHLTRTRAPSKVRPLKSKRYVLRMASTGGLDA 560
            .|       ..|.:.||.|:|:.                 .|.:|..|.:..|....|.....|.
Zfish   877 EAFDSVTIYFSDIVGFTALSAES-----------------TPMEVVTLLNDLYTCFDAIIDNFDV 924

  Fly   561 YLIRRTSQLRLTKPDVIQKDQIHSMPDPHVLELILSNDDEYLVVG-----NAQLWSVMDIDRAAR 620
            |.:....                               |.|:||.     |.:|        .||
Zfish   925 YKVETIG-------------------------------DAYMVVSGLPVRNGKL--------HAR 950

  Fly   621 EIRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFRHLGTDVDHLIRELKQSVRKKPQ---PVSL 682
            ||.:...:||.|      ..||           |.||                  :|.   .:.:
Zfish   951 EIARMSLALLEA------VHSF-----------RIRH------------------RPNLQLRLRI 980

  Fly   683 PLSSGSVC--------KRTCC--DRSNACRHRAIEQEPLAGRSSPSGQSDRDLLAKDKDDEFVLA 737
            .:.||.||        .|.|.  |..|.           |.|...:|::.:..:::        |
Zfish   981 GIHSGPVCAGVVGLKMPRYCLFGDTVNT-----------ASRMESNGEALKIHVSE--------A 1026

  Fly   738 HARVLQEEQ--QLEMLDETE 755
            ...||||..  |||:..:.|
Zfish  1027 TRAVLQEFNCFQLELRGDVE 1046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	3/18 (17%)
		LRR_8	109..169	CDD:290566	15/79 (19%)
		leucine-rich repeat	111..135	CDD:275380	8/42 (19%)
		leucine-rich repeat	136..158	CDD:275380	6/22 (27%)
		leucine-rich repeat	159..183	CDD:275380	3/31 (10%)
		leucine-rich repeat	184..209	CDD:275380	4/29 (14%)
		LRR_8	205..266	CDD:290566	6/60 (10%)
		leucine-rich repeat	210..230	CDD:275380	2/19 (11%)
		leucine-rich repeat	232..255	CDD:275380	3/22 (14%)
		LRR_RI	<256..410	CDD:238064	38/205 (19%)
		leucine-rich repeat	256..276	CDD:275380	2/19 (11%)
		LRR_8	279..359	CDD:290566	26/131 (20%)
		leucine-rich repeat	280..303	CDD:275380	5/22 (23%)
		leucine-rich repeat	304..348	CDD:275380	17/95 (18%)
		leucine-rich repeat	349..372	CDD:275380	7/22 (32%)
		PP2Cc	461..655	CDD:294085	36/205 (18%)
npr1a	NP_001038402.1	PBP1_NPR_A	48..449	CDD:107380
		ANF_receptor	66..421	CDD:279440
		PK_GC-A_B	540..814	CDD:270944	59/338 (17%)
		TyrKc	554..808	CDD:197581	53/318 (17%)
		HNOBA	<823..868	CDD:285003	16/125 (13%)
		CYCc	847..1032	CDD:214485	56/325 (17%)
		Guanylate_cyc	874..1060	CDD:278633	52/282 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900