DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and lrig1

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_688817.4	Gene:	lrig1 / 560325	ZFINID:	ZDB-GENE-031113-23	Length:	1022	Species:	Danio rerio

Alignment Length:	945	Identity:	186/945 - (19%)
Similarity:	299/945 - (31%)	Gaps:	373/945 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 GSILIGNYNYLTQLEVCENEMEVLDLSSLAQLETLKCSRNKLME---------LIINGTNLQTLV 115
            ||:....:.:|..||:..|.......:....|:|..|||..:.:         :.:|.::.:...
Zfish     9 GSLSYHVFYWLLTLELLINYGAPCPQNCTCTLDTTDCSRLDMTDVPQDLPKSTVHLNLSHNKLTA 73

  Fly   116 ADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNV-AVLLRNY 179
            .|.:.|.|:.         .|:.:.:.||..:.:|::..|.||:..:...|||:..: ..||:|:
Zfish    74 VDMDILSNLP---------HLREVRLDHNELTSIPSFGDAAASVVTLLLHHNRIRRLEGSLLQNF 129

  Fly   180 RITELVSLDLAYNDLKQLDQ--FPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKL 242
              :.|.:|||:.||:.:|.:  ||.|. .|:.|.|.||::..|....|......|:.|.:|.|:|
Zfish   130 --SALETLDLSNNDITELREHCFPLGL-QIKDLHLSSNKIVHLEFGAFKNLAGSLQILRLSRNRL 191

  Fly   243 STLP------------RYEQNNHAALVNLSLAG--------------NHLNDSIFEPLHNAAKLR 281
            :.||            ...:|....:..|:..|              :.|.|..|..|   |::|
Zfish   192 THLPVKGLELPKLTQLELSRNRLRLIEGLTFQGLSSLEVLKLQRNNISKLTDGAFWGL---ARMR 253

  Fly   282 VLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQL-PEEVATLGQLRVLRCC-NNLL-LCTPQL 343
            ||||.||.:..:.:..:.....|..|.|:.|.:... ||......:||.|... |||. |.....
Zfish   254 VLHLDYNSLREVNSGSLYGLESLLQLYLANNSISNFNPEGWGFCERLRELNLSYNNLTKLSEGSF 318

  Fly   344 AKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVS 408
            |||..|..|.|.||.:..:...|.....:|:.|:|..|                        |:|
Zfish   319 AKLVNLISLRLGHNSISHITEGAFRGLSSLRTLELDHN------------------------DIS 359

  Fly   409 GNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMF 473
            |                  ....|||.:|       |..:..||:::..:..:.  :.:|..|:
Zfish   360 G------------------TIEDTSGAFT-------GLENLNKLTLFGNKIKSV--AKKAFSGL- 396

  Fly   474 EALEGRGRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAALFHLTRTRAPS 538
            ||||          ||         .:.::|:|...                           |.
Zfish   397 EALE----------HL---------NLGENAIRSIQ---------------------------PE 415

  Fly   539 KVRPLKSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHVLELILSNDDEYLV 603
            ....:|:.||                    |.:.....:...|:|..||
Zfish   416 AFSKMKNLRY--------------------LHIQSDSFLCDCQLHWFPD---------------- 444

  Fly   604 VGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFRHLGTDV------ 662
                  |                  ||.......:..:.|..|||.         ||.:
Zfish   445 ------W------------------LLTRGLNPGVQATCAHPESLK---------GTSIYQAPPQ 476

  Fly   663 ----DHLIRELKQSVRKKPQ----PVSLPLSSGSVCKRTCCDRSNACRHRAIEQEPLAGRSSP-- 717
                |.|         .|||    ||:.....|...:.||...|::              |||
Zfish   477 SFVCDDL---------PKPQITVHPVTTAAVLGKDVRLTCTAASSS--------------SSPMT 518

  Fly   718 -SGQSDRDLLAKDKDDEFVLAHAR-----VLQEEQQLEMLDETESVSESVLSEEQFKCWEYMLEQ 776
             :...|::.|.:.:.:.|  ||.|     |::....|.:...|.:      .|.:::|
Zfish   519 FTWLKDQETLRQAEVENF--AHVRASDGGVMEYTTILHLRHVTFN------HEGRYQC------- 568

  Fly   777 NTQLLFDKELNTISKSF-----TKQRTVPNAIMAATVLPERNDFTSNLMRTVTNKFISTSTPQLP 836
                       .||..|     .|.|...|      |||               .|:.|     |
Zfish   569 -----------IISNHFGSSYSNKARVTVN------VLP---------------SFVKT-----P 596

  Fly   837 QPITTSVPLGSYHQVKQAPPGHFGSALSFQQAHSYGYNLFDAKPRPKFHGGTVKRSAGPNSAYFG 901
            :.||  :..|:..:::.|..||....:::|:                 .|||
Zfish   597 RDIT--IRTGTKARLECAAEGHPTPQVAWQK-----------------DGGT------------- 629

  Fly   902 SLQRLMPYNFEYDFAVTQERERNILDEEEHDDDDF 936
                        ||...:||...::.    |||.|
Zfish   630 ------------DFPAARERRMRVMP----DDDVF 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	6/27 (22%)
		LRR_8	109..169	CDD:290566	12/59 (20%)
		leucine-rich repeat	111..135	CDD:275380	3/23 (13%)
		leucine-rich repeat	136..158	CDD:275380	5/21 (24%)
		leucine-rich repeat	159..183	CDD:275380	6/24 (25%)
		leucine-rich repeat	184..209	CDD:275380	11/26 (42%)
		LRR_8	205..266	CDD:290566	17/86 (20%)
		leucine-rich repeat	210..230	CDD:275380	6/19 (32%)
		leucine-rich repeat	232..255	CDD:275380	8/34 (24%)
		LRR_RI	<256..410	CDD:238064	42/170 (25%)
		leucine-rich repeat	256..276	CDD:275380	6/33 (18%)
		LRR_8	279..359	CDD:290566	28/82 (34%)
		leucine-rich repeat	280..303	CDD:275380	7/22 (32%)
		leucine-rich repeat	304..348	CDD:275380	16/46 (35%)
		leucine-rich repeat	349..372	CDD:275380	6/22 (27%)
		PP2Cc	461..655	CDD:294085	26/193 (13%)
lrig1	XP_688817.4	LRRNT	31..63	CDD:214470	5/31 (16%)
		leucine-rich repeat	63..84	CDD:275380	4/29 (14%)
		LRR_RI	77..334	CDD:238064	75/271 (28%)
		LRR_8	83..142	CDD:290566	18/69 (26%)
		leucine-rich repeat	85..107	CDD:275380	5/21 (24%)
		leucine-rich repeat	108..131	CDD:275380	6/24 (25%)
		LRR_8	132..191	CDD:290566	21/59 (36%)
		leucine-rich repeat	132..155	CDD:275380	10/23 (43%)
		leucine-rich repeat	156..180	CDD:275380	7/23 (30%)
		leucine-rich repeat	181..203	CDD:275380	7/21 (33%)
		LRR_8	202..262	CDD:290566	15/62 (24%)
		leucine-rich repeat	204..227	CDD:275380	3/22 (14%)
		leucine-rich repeat	228..251	CDD:275380	4/25 (16%)
		LRR_8	251..310	CDD:290566	17/58 (29%)
		leucine-rich repeat	252..275	CDD:275380	7/22 (32%)
		leucine-rich repeat	276..299	CDD:275380	6/22 (27%)
		LRR_8	299..358	CDD:290566	20/82 (24%)
		leucine-rich repeat	300..323	CDD:275380	10/22 (45%)
		leucine-rich repeat	324..347	CDD:275380	6/22 (27%)
		leucine-rich repeat	348..372	CDD:275380	11/72 (15%)
		LRR_4	373..414	CDD:289563	12/89 (13%)
		LRR_8	374..433	CDD:290566	17/127 (13%)
		leucine-rich repeat	375..398	CDD:275380	4/25 (16%)
		leucine-rich repeat	399..420	CDD:275380	7/66 (11%)
		LRRCT	433..481	CDD:214507	13/96 (14%)
		Ig_3	485..572	CDD:290638	24/126 (19%)
		IG_like	492..586	CDD:214653	25/133 (19%)
		I-set	590..680	CDD:254352	22/127 (17%)
		Ig_1	607..681	CDD:143240	15/88 (17%)
		I-set	684..771	CDD:254352
		IGc2	698..761	CDD:197706
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910