DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and ADCY10

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_060887.2 Gene:ADCY10 / 55811 HGNCID:21285 Length:1610 Species:Homo sapiens


Alignment Length:343 Identity:71/343 - (20%)
Similarity:125/343 - (36%) Gaps:90/343 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    81 EVLDLSSLAQLETLKCSRNKLMELIINGTNLQTLVADHNYLHNIS------TTNTHPVPLKLQRI 139
            |:..:|:|.:.:.|:....|:::||:....:..::.:..::.:.|      ...|.|:     .|
Human   609 EISRMSTLKKQKQLEILFMKILKLIVKEERIIFIIDEAQFVDSTSWRFMEKLIRTLPI-----FI 668

  Fly   140 DISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDL-KQLDQF-PE 202
            .:|...|..:|     ||:..|:..:.|....|...::...|:..:.|||..:.: |:||.: .|
Human   669 IMSLCPFVNIP-----CAAARAVIKNRNTTYIVIGAVQPNDISNKICLDLNVSCISKELDSYLGE 728

  Fly   203 GFSSI--------RSL---------QLQSNELPSLP-DNFFAVTHARLETLNV-----------S 238
            |...|        ::|         |.:|.|..:.. :|.|..:....|.||:           .
Human   729 GSCGIPFYCEELLKNLEHHEVLVFQQTESEEKTNRTWNNLFKYSIKLTEKLNMVTLHSDKESEEV 793

  Fly   239 CN-----KLSTLPRYEQNNHAALVNL-SLAGNH--------------LNDSIFE--PLHNAAKLR 281
            |:     :|..|.........:|:.| |:..:|              ..:.:||  |..| .|:.
Human   794 CHLTSGVRLKNLSPPTSLKEISLIQLDSMRLSHQMLVRCAAIIGLTFTTELLFEILPCWN-MKMM 857

  Fly   282 VLHLA----------YNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLG---QLRVLRC- 332
            :..||          :.....|..|..:|.|..|:...|   |...|.|....|   |||.|.. 
Human   858 IKTLATLVESNIFYCFRNGKELQKALKQNDPSFEVHYRS---LSLKPSEGMDHGEEEQLRELENE 919

  Fly   333 ---CNNLLLCTPQLAKLA 347
               |:.:..|.|.:.|.|
Human   920 VIECHRIRFCNPMMQKTA 937

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380 4/18 (22%)
LRR_8 109..169 CDD:290566 11/65 (17%)
leucine-rich repeat 111..135 CDD:275380 3/29 (10%)
leucine-rich repeat 136..158 CDD:275380 5/21 (24%)
leucine-rich repeat 159..183 CDD:275380 4/23 (17%)
leucine-rich repeat 184..209 CDD:275380 9/34 (26%)
LRR_8 205..266 CDD:290566 17/109 (16%)
leucine-rich repeat 210..230 CDD:275380 6/29 (21%)
leucine-rich repeat 232..255 CDD:275380 6/38 (16%)
LRR_RI <256..410 CDD:238064 30/126 (24%)
leucine-rich repeat 256..276 CDD:275380 7/36 (19%)
LRR_8 279..359 CDD:290566 22/86 (26%)
leucine-rich repeat 280..303 CDD:275380 5/32 (16%)
leucine-rich repeat 304..348 CDD:275380 15/51 (29%)
leucine-rich repeat 349..372 CDD:275380
PP2Cc 461..655 CDD:294085
ADCY10NP_060887.2 CHD 40..214 CDD:143636
AcyC <42..197 CDD:225025
CHD 292..461 CDD:143636
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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