DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and adcy1a

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_001161821.1 Gene:adcy1a / 557026 ZFINID:ZDB-GENE-070705-302 Length:1114 Species:Danio rerio


Alignment Length:314 Identity:63/314 - (20%)
Similarity:108/314 - (34%) Gaps:103/314 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   203 GFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKL---------STLPRYEQNNHAALVN 258
            |:..:.::.|.|..|         |.|.|...|.:..:.|         ..:.|.:.:|...|.|
Zfish   777 GYDPVLAMLLFSGAL---------VLHCRQLDLKLRLDYLWATQAEEERDDMERVKLDNKRILFN 832

  Fly   259 LSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNM----LQQLPE 319
            |..|  |:.....  |.|...:.:.:.:|:::||| .|.:.|:.:..|.:...||    |:.|.|
Zfish   833 LLPA--HVAQHFL--LSNPRNMDLYYQSYSQVGVL-FASIPNFNDFYIELDGNNMGVECLRLLNE 892

  Fly   320 EVATLGQLRVLRCCNNL------------------------------LLCTPQLAKLAMLKVLDL 354
            .:|....|....|..::                              .|||.....:.|..|||.
Zfish   893 IIADFDALMDKECYRDIEKIKTIGSTYMAAVGLVPTEGSKVKKSISAHLCTVADYAIEMFDVLDA 957

  Fly   355 ----SHN-HLDRVNL------LALVPSRNLKYLDLSGNL--------------QLQVDEQQFKV- 393
                |:| .:.||.:      ..::.:|..:| |:.||.              ::||.|..|:: 
Zfish   958 INYQSYNDFVLRVGINVGPVVAGVIGARRPQY-DIWGNTVNVASRMDSTGVQGKIQVTEDVFRLL 1021

  Fly   394 -------CQSQSQRHWSLVDVSGNNRAAL-----PTTKIRQVSAQRNQNKTSGP 435
                   |:.|       |.|.|..:...     .|.:..|.|..::.::.|.|
Zfish  1022 SGYYDFNCRGQ-------VSVKGKGQMLTYFLEGRTPQGAQHSRSKSPDQDSSP 1068

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380
LRR_8 109..169 CDD:290566
leucine-rich repeat 111..135 CDD:275380
leucine-rich repeat 136..158 CDD:275380
leucine-rich repeat 159..183 CDD:275380
leucine-rich repeat 184..209 CDD:275380 1/5 (20%)
LRR_8 205..266 CDD:290566 14/69 (20%)
leucine-rich repeat 210..230 CDD:275380 4/19 (21%)
leucine-rich repeat 232..255 CDD:275380 4/31 (13%)
LRR_RI <256..410 CDD:238064 46/220 (21%)
leucine-rich repeat 256..276 CDD:275380 6/19 (32%)
LRR_8 279..359 CDD:290566 24/118 (20%)
leucine-rich repeat 280..303 CDD:275380 6/22 (27%)
leucine-rich repeat 304..348 CDD:275380 12/77 (16%)
leucine-rich repeat 349..372 CDD:275380 7/33 (21%)
PP2Cc 461..655 CDD:294085
adcy1aNP_001161821.1 AC_N <154..285 CDD:292831
CYCc 251..446 CDD:214485
Guanylate_cyc 287..469 CDD:278633
DUF1053 513..601 CDD:283888
CYCc 819..1029 CDD:214485 44/215 (20%)
Guanylate_cyc 852..1048 CDD:278633 40/204 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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