DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and LRRC40

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_060238.3	Gene:	LRRC40 / 55631	HGNCID:	26004	Length:	602	Species:	Homo sapiens

Alignment Length:	621	Identity:	140/621 - (22%)
Similarity:	229/621 - (36%)	Gaps:	150/621 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 GQTSPQKLSLKGSQLGGSILIGNYNYLTQLEVCENEMEVLDLSSLAQLETLK-------CSRNKL 101
            |.:.||.| ||.::..|.:.:...| |:::..|...:.| |:...|. :.|.       ..:..|
Human    24 GTSVPQGL-LKAARKSGQLNLSGRN-LSEVPQCVWRINV-DIPEEAN-QNLSFGATERWWEQTDL 84

  Fly   102 MELIINGTNLQTLVADHNYLHNISTTNTHPVPL-----------KLQRIDISHNNFSELPNWVGA 155
            .:|||:...||:|..|...|..::..:.|...|           .||::::|||....||..:..
Human    85 TKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITN 149

  Fly   156 CASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRS---LQLQSNEL 217
            ..:|..:...||.|..::....  :::.|..|||:.|.|..:   |..|||:.|   |.|.||||
Human   150 LRNLKCLYLQHNELTCISEGFE--QLSNLEDLDLSNNHLTTV---PASFSSLSSLVRLNLSSNEL 209

  Fly   218 PSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEP-LHNAAKLR 281
            .|||.....:  .||:.|:.:.|.|.|:|    ...|.:.:|.|.....|...|.| ..:.:.|:
Human   210 KSLPAEINRM--KRLKHLDCNSNLLETIP----PELAGMESLELLYLRRNKLRFLPEFPSCSLLK 268

  Fly   282 VLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKL 346
            .||:..|:|.:|.|..:::...:.:|.|..|.|:.:|:|:..|..|..|...||.:...|.....
Human   269 ELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGN 333

  Fly   347 AMLKVLDLSHNHL--------------------------------------------DRVNLLAL 367
            ..||.|.|..|.|                                            .|||:.|:
Human   334 LHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAI 398

  Fly   368 VPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPT--------------- 417
            :   .||.||.|......:.::.|...:|...   :.::.|.|....:|.
Human   399 I---TLKILDYSDKQATLIPDEVFDAVKSNIV---TSINFSKNQLCEIPKRMVELKEMVSDVDLS 457

  Fly   418 -TKIRQVSAQ------------RNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGS---- 465
             .|:..:|.:            ||....|.|..|.             |:.:|:..|...:
Human   458 FNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEME-------------SLVRLQTINLSFNRFKM 509

  Fly   466 -DEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQ---CGSVRSA 526
             .|.||.:| .||....:..::..:.|..||   |:::....|.....||....:   |.::|:.
Human   510 LPEVLYRIF-TLETILISNNQVGSVDPQKMK---MMENLTTLDLQNNDLLQIPPELGNCVNLRTL 570

  Fly   527 ALFHLTRTRAPSKVRPLKSKRYVLRMASTGGLDAYL 562
            .|          ...|.:..|..:.|..|..:..||
Human   571 LL----------DGNPFRVPRAAILMKGTAAILEYL 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	5/25 (20%)
		LRR_8	109..169	CDD:290566	17/70 (24%)
		leucine-rich repeat	111..135	CDD:275380	7/34 (21%)
		leucine-rich repeat	136..158	CDD:275380	7/21 (33%)
		leucine-rich repeat	159..183	CDD:275380	4/23 (17%)
		leucine-rich repeat	184..209	CDD:275380	10/24 (42%)
		LRR_8	205..266	CDD:290566	22/63 (35%)
		leucine-rich repeat	210..230	CDD:275380	9/19 (47%)
		leucine-rich repeat	232..255	CDD:275380	6/22 (27%)
		LRR_RI	<256..410	CDD:238064	42/198 (21%)
		leucine-rich repeat	256..276	CDD:275380	5/20 (25%)
		LRR_8	279..359	CDD:290566	24/79 (30%)
		leucine-rich repeat	280..303	CDD:275380	7/22 (32%)
		leucine-rich repeat	304..348	CDD:275380	12/43 (28%)
		leucine-rich repeat	349..372	CDD:275380	10/66 (15%)
		PP2Cc	461..655	CDD:294085	23/110 (21%)
LRRC40	NP_060238.3	leucine-rich repeat	41..83	CDD:275380	7/44 (16%)
		LRR 1	83..104		8/20 (40%)
		LRR_8	84..140	CDD:316378	16/55 (29%)
		leucine-rich repeat	84..106	CDD:275380	9/21 (43%)
		LRR 2	106..127		2/20 (10%)
		leucine-rich repeat	107..129	CDD:275380	2/21 (10%)
		PLN00113	120..>577	CDD:331614	109/500 (22%)
		LRR 3	129..150		7/20 (35%)
		leucine-rich repeat	130..152	CDD:275380	7/21 (33%)
		LRR 4	152..173		4/22 (18%)
		leucine-rich repeat	153..175	CDD:275380	4/23 (17%)
		LRR 5	175..196		9/23 (39%)
		leucine-rich repeat	176..198	CDD:275380	10/24 (42%)
		LRR 6	198..219		10/20 (50%)
		leucine-rich repeat	199..221	CDD:275380	9/23 (39%)
		LRR 7	221..242		8/24 (33%)
		leucine-rich repeat	222..244	CDD:275380	7/25 (28%)
		LRR 8	244..265		5/20 (25%)
		leucine-rich repeat	245..266	CDD:275380	5/20 (25%)
		LRR 9	266..286		7/19 (37%)
		leucine-rich repeat	267..290	CDD:275380	7/22 (32%)
		LRR 10	290..311		6/20 (30%)
		leucine-rich repeat	291..313	CDD:275380	7/21 (33%)
		LRR 11	313..335		5/21 (24%)
		LRR 12	336..356		6/19 (32%)
		LRR 13	400..421		6/20 (30%)
		LRR 14	426..447		3/23 (13%)
		leucine-rich repeat	447..473	CDD:275380	2/25 (8%)
		LRR 15	450..472		2/21 (10%)
		LRR 16	473..494		5/33 (15%)
		leucine-rich repeat	474..496	CDD:275380	6/34 (18%)
		LRR 17	496..517		5/20 (25%)
		leucine-rich repeat	497..543	CDD:275380	12/49 (24%)
		LRR 18	519..540		5/23 (22%)
		LRR 19	543..564		3/20 (15%)
		leucine-rich repeat	544..566	CDD:275380	4/21 (19%)
		LRR 20	566..586		4/29 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45752
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010