DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and Gucy1b1

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_059497.1	Gene:	Gucy1b1 / 54195	MGIID:	1860604	Length:	620	Species:	Mus musculus

Alignment Length:	280	Identity:	58/280 - (20%)
Similarity:	96/280 - (34%)	Gaps:	77/280 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 LPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAAC--VRNWPELEIL 307
            ||:.:..|.:.|...||...|::.|....|.:...:.||......:.|....|  .....|:..|
Mouse   240 LPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGAEISCL 304

  Fly   308 VLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHL--------DRVNL 364
            .|.|.|: .|||..:.            |.||:|.:..|.     ||:...|        |....
Mouse   305 RLKGQMI-YLPEADSI------------LFLCSPSVMNLD-----DLTRRGLYLSDIPLHDATRD 351

  Fly   365 LALVPSRNLKYLDLSGNLQLQVDEQQ--FKVCQSQSQRHWSLVDVSGNNRAALPTTKI------R 421
            |.|:..:..:...|:..|::..|..|  .:..:.:.::..:|:      .:.||.:..      |
Mouse   352 LVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLL------YSVLPPSVANELRHKR 410

  Fly   422 QVSAQRNQNKT---SGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAA 483
            .|.|:|..|.|   ||  .:||     :..|.|                         ...|..|
Mouse   411 PVPAKRYDNVTILFSG--IVGF-----NAFCSK-------------------------HASGEGA 443

  Fly   484 QEMSHLVPDLMKQEQMVKDS 503
            .::.:|:.||..:...:.||
Mouse   444 MKIVNLLNDLYTRFDTLTDS 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380
		leucine-rich repeat	184..209	CDD:275380
		LRR_8	205..266	CDD:290566	6/20 (30%)
		leucine-rich repeat	210..230	CDD:275380
		leucine-rich repeat	232..255	CDD:275380	3/9 (33%)
		LRR_RI	<256..410	CDD:238064	34/165 (21%)
		leucine-rich repeat	256..276	CDD:275380	6/19 (32%)
		LRR_8	279..359	CDD:290566	19/81 (23%)
		leucine-rich repeat	280..303	CDD:275380	4/24 (17%)
		leucine-rich repeat	304..348	CDD:275380	12/43 (28%)
		leucine-rich repeat	349..372	CDD:275380	6/30 (20%)
		PP2Cc	461..655	CDD:294085	7/43 (16%)
Gucy1b1	NP_059497.1	HNOB	2..166	CDD:311572
		HNOBA	207..406	CDD:311573	39/189 (21%)
		Guanylate_cyc	412..605	CDD:306677	18/84 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900