DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and ACXE

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_652601.3	Gene:	ACXE / 53426	FlyBaseID:	FBgn0040506	Length:	1123	Species:	Drosophila melanogaster

Alignment Length:	279	Identity:	58/279 - (20%)
Similarity:	103/279 - (36%)	Gaps:	56/279 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 NEMEVLDLSSLAQLETLKCSRNKLMEL-IINGTNLQTLVADHNYLHNISTTNTHPVPLKLQRIDI 141
            |...:|.||.:          |.:||: .|:|.::...:..|:............:...:..:|:
  Fly   365 NNCVILGLSMI----------NHIMEVRDIHGLDINMRIGVHSGNLFAGVIGEAKLQFDIWGLDV 419

  Fly   142 SHNNFSELPNWVGACASLTAINASHNRLNNVAV----------------LLRNYRI-TELVSLDL 189
            :..|..| ...|..|     ::.|...|||:.|                ||:.||| :.::..||
  Fly   420 TIANVLE-STGVPGC-----VHISGATLNNLDVNRFDIEDGPEEARDHPLLKKYRIRSYIIRQDL 478

  Fly   190 AYNDLKQLDQFPEGFSSIRSLQLQSNELPSLPD----NFFAVTHARL----ETLNVSC---NKLS 243
            ..:| :..|:|.....||....:.:.  |.:.|    :..|:.|..|    ..:.||.   .:|.
  Fly   479 HMDD-EDSDEFLGDLHSISLCNMGAQ--PRISDSANQSLRALFHEELREEFRKMPVSAFSPKRLL 540

  Fly   244 TLPRYEQNNHA-ALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAA--CVRNWPELE 305
            .:.|:...... |..||::.     .:..:|:...|.|:.....|....:|.|:  |...:.||.
  Fly   541 GICRFNTGKEVPAHQNLNIC-----LTFTDPILERAYLKQTDYMYKYSIILSASVGCSLVYIELM 600

  Fly   306 ILVLSGNMLQQLPEEVATL 324
            ...:..:....||..|||:
  Fly   601 DTQMICSSCFVLPASVATI 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	5/19 (26%)
		LRR_8	109..169	CDD:290566	7/59 (12%)
		leucine-rich repeat	111..135	CDD:275380	1/23 (4%)
		leucine-rich repeat	136..158	CDD:275380	5/21 (24%)
		leucine-rich repeat	159..183	CDD:275380	10/40 (25%)
		leucine-rich repeat	184..209	CDD:275380	7/24 (29%)
		LRR_8	205..266	CDD:290566	14/72 (19%)
		leucine-rich repeat	210..230	CDD:275380	3/23 (13%)
		leucine-rich repeat	232..255	CDD:275380	5/30 (17%)
		LRR_RI	<256..410	CDD:238064	16/71 (23%)
		leucine-rich repeat	256..276	CDD:275380	3/19 (16%)
		LRR_8	279..359	CDD:290566	12/48 (25%)
		leucine-rich repeat	280..303	CDD:275380	5/24 (21%)
		leucine-rich repeat	304..348	CDD:275380	6/21 (29%)
		leucine-rich repeat	349..372	CDD:275380
		PP2Cc	461..655	CDD:294085
ACXE	NP_652601.3	AC_N	<31..272	CDD:318454
		Nucleotidyl_cyc_III	290..459	CDD:325147	20/109 (18%)
		Nucleotidyl_cyc_III	851..1071	CDD:325147
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900