DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and Phlpp2

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001102601.2	Gene:	Phlpp2 / 498949	RGDID:	1562857	Length:	1359	Species:	Rattus norvegicus

Alignment Length:	978	Identity:	242/978 - (24%)
Similarity:	397/978 - (40%)	Gaps:	202/978 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LIGNYNYLTQLEVCENEMEVLDLSSLAQLETLKCSRNKLMELIINGTNLQTLVADHNYLHNISTT 127
            |.|| .::|.:::.:|::..||||||..||.|.|.||:|.||.::|.:|:.|.|:.|   .::..
  Rat   471 LEGN-KHITHMDLRDNQLTDLDLSSLCSLEQLHCERNQLRELTLSGFSLRNLYANWN---KLTAV 531

  Fly   128 NTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAV-LLRNYRITELVSLDLAY 191
            |.:|||..|..:::|.|....:|:|......|..::.|:|.|..|.: :|.:..:.:|:   :.:
  Rat   532 NVYPVPSLLTSLELSRNLLECIPDWACEAKKLEILDISYNLLTEVPMRILSSLSLRKLM---VGH 593

  Fly   192 NDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPR--YEQNNHA 254
            |.:..|....|.. .:..|.:|.|.|..|||..|:.. ..|..||.|.|.|.:||.  ..:.:.:
  Rat   594 NHIHVLPALVEHI-PLEVLDVQHNTLSRLPDTLFSKA-LNLRYLNASANSLESLPSACAGEESLS 656

  Fly   255 ALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPE 319
            .|..|.|..|.|.|.....|.....|||||||.|::...||:.:....:||.|.||||.|:.:|.
  Rat   657 VLQLLYLTNNLLTDQCIPVLVGHPHLRVLHLANNQLQTFPASKLNKLEQLEELNLSGNKLKAIPT 721

  Fly   320 EVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQL 384
            .:|...:|..|....|.:...|::.:|..::.:|||.|.|..:.:...:|: .|:.|||:||..|
  Rat   722 TIANCKRLHTLVAHANNISIFPEILQLPQIQFVDLSCNDLTEILIPETLPA-TLQDLDLTGNTNL 785

  Fly   385 QVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDC 449
            .::.:...:        :|.:.....::..||||         :...||..|:.|.||.  :|..
  Rat   786 VLEHKTLDM--------FSHITTLKIDQKPLPTT---------DSTVTSTFWSHGLAEM--AGQR 831

  Fly   450 RKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQ---EQMVKDSAVRDYMKF 511
            .||.|..|...|:.....|:||||:     |...:|:..|:...|..   |::...::...:|..
  Rat   832 NKLCVSALAMDNFAEGVGAVYGMFD-----GDRNEELPRLLQCTMADVLLEEVQHSTSDTVFMAN 891

  Fly   512 TLLAAQQQCG----SVRSAALFHLTRTRAPSKVRPLKSKRYVLRMASTGGLDAYLIRRTSQLRLT 572
            |.|.:.::.|    .:.|:||....|   |....|..|  :.|.:|:.|...|.|.|....:.|:
  Rat   892 TFLVSHRKLGMAGQKLGSSALLCYIR---PDTADPTSS--FSLTVANVGTCQAVLCRGGKPVPLS 951

  Fly   573 K-------PDVIQ--KDQ---------IHS-----------------MPDPHVLELILSNDDEYL 602
            |       |:..|  |||         ::.                 :|.||:....|:..||.|
  Rat   952 KVFSLEHDPEEAQRVKDQKAIITEDNKVNGVTCCTRMLGCTYLYPWILPKPHISSTPLTIQDELL 1016

  Fly   603 VVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFRHLGTDVDHLIR 667
            ::||..||..:....|...:|..::.|.|||:|..:|||:...:::..:||   :|....:....
  Rat  1017 ILGNKALWEHLSYLEAVSAVRHVQDPLAAAKKLCTLAQSYGCQDNVGAMVV---YLNIGEEGCTC 1078

  Fly   668 EL-------------KQSVRKKPQPVSLPLSSG---------------SVCKRTCCDRSNAC--- 701
            |:             ..:::..|:|.:...|||               |....|..|..|..
  Rat  1079 EMHGLALPGPVGFASTATIKDAPKPTTPSSSSGIASELSSEVSTSEVSSEVGSTASDEHNTVGLE 1143

  Fly   702 --------RHRAIEQEPLAG--RSSP------SGQSDRDLLAKDKDD----EFVLAHARVLQEEQ 746
                    |..::...|.||  :..|      |.|||..|   |.||    |.|:.:...::.|.
  Rat  1144 TSLLPRPERRCSLHPVPSAGTFQRQPSCATFSSNQSDNGL---DSDDDQPVEGVITNGSRVEVEV 1205

  Fly   747 QLEMLDETESVSESVL-SEEQFKCWEYMLEQNTQLLFDKELNTISKSFTKQRTVPNAIMAATVLP 810
            .:......||.:...| ....:.|.|            :....:.....:|.:|.:.|:    ||
  Rat  1206 DIHCCRGRESENSPTLPKNSSYPCSE------------EHARGLGFGIRRQNSVNSGIL----LP 1254

  Fly   811 ERNDFTSNLMRTVTNKFISTSTPQLPQPITTSVPLGSYHQVKQAPPGHFGSALSFQQAHSYGYNL 875
            ...|                 ..:|.:..:||...|     |:...   ||.:..:.:    .||
  Rat  1255 VNKD-----------------KMELQKSPSTSCLYG-----KKLSN---GSIVPLEDS----LNL 1290

  Fly   876 FD-AKPRPKFHGGTVKRSAGPNSAYFGSLQRLMPYNFEYDFAVTQERERNILDEEEHDDDDFNEH 939
            .: |...|       ||..|    ||.:..:|.|   |..|.|.::.|..:.::.:...:...|.
  Rat  1291 IEVATEAP-------KRKTG----YFAAPTQLEP---EDQFVVPRDLEDEVKEQMKQHQESRPEP 1341

  Fly   940 ESR 942
            |.|
  Rat  1342 EPR 1344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	10/18 (56%)
		LRR_8	109..169	CDD:290566	16/59 (27%)
		leucine-rich repeat	111..135	CDD:275380	8/23 (35%)
		leucine-rich repeat	136..158	CDD:275380	5/21 (24%)
		leucine-rich repeat	159..183	CDD:275380	6/24 (25%)
		leucine-rich repeat	184..209	CDD:275380	4/24 (17%)
		LRR_8	205..266	CDD:290566	20/62 (32%)
		leucine-rich repeat	210..230	CDD:275380	8/19 (42%)
		leucine-rich repeat	232..255	CDD:275380	8/24 (33%)
		LRR_RI	<256..410	CDD:238064	46/153 (30%)
		leucine-rich repeat	256..276	CDD:275380	7/19 (37%)
		LRR_8	279..359	CDD:290566	29/79 (37%)
		leucine-rich repeat	280..303	CDD:275380	10/22 (45%)
		leucine-rich repeat	304..348	CDD:275380	15/43 (35%)
		leucine-rich repeat	349..372	CDD:275380	6/22 (27%)
		PP2Cc	461..655	CDD:294085	58/235 (25%)
Phlpp2	NP_001102601.2	RA_PHLPP2	66..178	CDD:340761
		PH_PHLPP-like	185..279	CDD:270131
		PLN00113	284..>762	CDD:215061	96/299 (32%)
		leucine-rich repeat	289..309	CDD:275380
		leucine-rich repeat	310..336	CDD:275380
		leucine-rich repeat	337..359	CDD:275380
		leucine-rich repeat	360..382	CDD:275380
		leucine-rich repeat	383..405	CDD:275380
		leucine-rich repeat	406..428	CDD:275380
		leucine-rich repeat	429..452	CDD:275380
		leucine-rich repeat	453..476	CDD:275380	3/5 (60%)
		leucine-rich repeat	477..497	CDD:275380	8/19 (42%)
		leucine-rich repeat	498..517	CDD:275380	10/18 (56%)
		leucine-rich repeat	518..539	CDD:275380	8/23 (35%)
		leucine-rich repeat	540..562	CDD:275380	5/21 (24%)
		leucine-rich repeat	563..584	CDD:275380	6/20 (30%)
		leucine-rich repeat	586..607	CDD:275380	4/24 (17%)
		leucine-rich repeat	608..631	CDD:275380	8/23 (35%)
		leucine-rich repeat	632..681	CDD:275380	15/48 (31%)
		leucine-rich repeat	682..705	CDD:275380	10/22 (45%)
		leucine-rich repeat	706..728	CDD:275380	10/21 (48%)
		leucine-rich repeat	751..772	CDD:275380	5/20 (25%)
		PP2Cc	820..1069	CDD:238083	67/263 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	194	1.000	Inparanoid score	I3757
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172467at2759
OrthoFinder	1	1.000	-	-		FOG0003647
OrthoInspector	1	1.000	-	-		otm45597
orthoMCL	1	0.900	-	-		OOG6_102913
Panther	1	1.100	-	-	O	PTHR45752
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.830