DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Phlpp and NPR2

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:XP_024303324.1 Gene:NPR2 / 4882 HGNCID:7944 Length:1103 Species:Homo sapiens


Alignment Length:271 Identity:50/271 - (18%)
Similarity:96/271 - (35%) Gaps:92/271 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 AAEEEQAATFGQTSPQKLSLKG-----SQLGGSILIGNYNYLTQLEVCENEME-VLDLSSLAQLE 92
            |.:..:...|||       :||     ::.||:.::.  |.|.::|...|.:| :::..:.|.||
Human   826 AQDPAERPDFGQ-------IKGFIRRFNKEGGTSILD--NLLLRMEQYANNLEKLVEERTQAYLE 881

  Fly    93 TLKCSRNKLMELIINGTNLQTLVADHNYLHNISTTNTHPVPLKLQRID-ISHNNFSELPNWVGAC 156
            ..:.:...|.:::                       .|.|..:|:|.: :....|..:..:....
Human   882 EKRKAEALLYQIL-----------------------PHSVAEQLKRGETVQAEAFDSVTIYFSDI 923

  Fly   157 ASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSLP 221
            ...||::|....:..|.:|                |||...                   ..::.
Human   924 VGFTALSAESTPMQVVTLL----------------NDLYTC-------------------FDAII 953

  Fly   222 DNFFAVTHARLETLNVSCNKLSTLPRYEQNNHA-ALVNLSLAGNHLNDSIFEPLHNAAKLRVLHL 285
            |||...   ::||:..:...:|.||......|| .:..::||   |.|::       :..|:.|.
Human   954 DNFDVY---KVETIGDAYMVVSGLPGRNGQRHAPEIARMALA---LLDAV-------SSFRIRHR 1005

  Fly   286 AYN----RIGV 292
            .::    ||||
Human  1006 PHDQLRLRIGV 1016

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380 3/18 (17%)
LRR_8 109..169 CDD:290566 8/60 (13%)
leucine-rich repeat 111..135 CDD:275380 2/23 (9%)
leucine-rich repeat 136..158 CDD:275380 3/22 (14%)
leucine-rich repeat 159..183 CDD:275380 5/23 (22%)
leucine-rich repeat 184..209 CDD:275380 3/24 (13%)
LRR_8 205..266 CDD:290566 12/61 (20%)
leucine-rich repeat 210..230 CDD:275380 3/19 (16%)
leucine-rich repeat 232..255 CDD:275380 7/23 (30%)
LRR_RI <256..410 CDD:238064 10/41 (24%)
leucine-rich repeat 256..276 CDD:275380 4/19 (21%)
LRR_8 279..359 CDD:290566 6/18 (33%)
leucine-rich repeat 280..303 CDD:275380 6/17 (35%)
leucine-rich repeat 304..348 CDD:275380
leucine-rich repeat 349..372 CDD:275380
PP2Cc 461..655 CDD:294085
NPR2XP_024303324.1 Periplasmic_Binding_Protein_Type_1 26..421 CDD:324556
PK_GC-A_B 521..848 CDD:270944 6/28 (21%)
HNOBA <857..902 CDD:311573 10/67 (15%)
CYCc 881..1065 CDD:214485 35/207 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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