DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and NPR1

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_000897.3 Gene:NPR1 / 4881 HGNCID:7943 Length:1061 Species:Homo sapiens


Alignment Length:627 Identity:106/627 - (16%)
Similarity:192/627 - (30%) Gaps:229/627 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   300 NWPELEILVLSGNMLQ----QLPEEVATLGQLRVLRCCNNLLLCTPQ----LAKLAMLKVLDLSH 356
            |....|::.:||..|.    ..|.::...|.......||...|.|.:    :..|::|.:|.:|.
Human   427 NGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSF 491

  Fly   357 -------------NHLDRVNLLALVPS---RNLK----YLDLSGN----LQLQVDEQQFKVCQSQ 397
                         :.|.||....:.||   |:|:    .|.|||.    ..|...|.||:|....
Human   492 FIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKT 556

  Fly   398 SQRHWSLVDVSGNNRAALPTTK-----IRQVSAQRNQNKT------SGP---------------- 435
            :....:||.|...||..:..|:     ::.:...:|::.|      :.|                
Human   557 AYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQ 621

  Fly   436 -----------WTMGFAETPG--------------------SGDCRKLSVYQLRAANYGGSDEAL 469
                       |...::.|..                    |.:|.....:.|:..:||      
Human   622 DILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYG------ 680

  Fly   470 YGMFEALEGRGRAAQEMSHLV--------PDLMKQ-EQMVKDSAVRDYMKFTLLAAQQQCGSVRS 525
                  ||.......|..|.|        |:|::. ...|:.|...|...|.::..:.   ::||
Human   681 ------LESFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEI---ALRS 736

  Fly   526 AALFHLTRTRAPSKVRPLKSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHV 590
             .:||:.                        |||           |:..::|::......| |..
Human   737 -GVFHVE------------------------GLD-----------LSPKEIIERVTRGEQP-PFR 764

  Fly   591 LELILSNDDEYLVVGNAQLWS--------VMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAES 647
            ..|.|.:..|.|.:...:.|:        ...|....|:..:|.:|.:                 
Human   765 PSLALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRENSSNI----------------- 812

  Fly   648 LSVIVVRFRHLGTDVDHLIRELKQSVRKKPQPVS------LPLSSGSVCKRTCCDRSNACRHRAI 706
            |..::.|......:::.|:.|..|:..::.:...      ||.|.....||....::.|.....|
Human   813 LDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTI 877

  Fly   707 EQEPLAGRSSPSGQSDRDLLAKDKDDEFVLAHARVLQEEQQLEMLDETESVSESVLSEEQFKCWE 771
            ....:.|.::.|.:|                     ...|.:.:|::.            :.|::
Human   878 YFSDIVGFTALSAES---------------------TPMQVVTLLNDL------------YTCFD 909

  Fly   772 YMLEQNTQLLFDKELNTISKSFTKQRTVPNAIMAATVLPERN 813
            .:::.     ||         ..|..|:.:|.|..:.||.||
Human   910 AVIDN-----FD---------VYKVETIGDAYMVVSGLPVRN 937

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380
LRR_8 109..169 CDD:290566
leucine-rich repeat 111..135 CDD:275380
leucine-rich repeat 136..158 CDD:275380
leucine-rich repeat 159..183 CDD:275380
leucine-rich repeat 184..209 CDD:275380
LRR_8 205..266 CDD:290566
leucine-rich repeat 210..230 CDD:275380
leucine-rich repeat 232..255 CDD:275380
LRR_RI <256..410 CDD:238064 34/141 (24%)
leucine-rich repeat 256..276 CDD:275380
LRR_8 279..359 CDD:290566 15/79 (19%)
leucine-rich repeat 280..303 CDD:275380 1/2 (50%)
leucine-rich repeat 304..348 CDD:275380 11/51 (22%)
leucine-rich repeat 349..372 CDD:275380 8/38 (21%)
PP2Cc 461..655 CDD:294085 34/210 (16%)
NPR1NP_000897.3 PBP1_NPR_A 36..443 CDD:107380 5/15 (33%)
ANF_receptor 54..414 CDD:279440
PK_GC-A_B 534..807 CDD:270944 52/324 (16%)
TyrKc 547..801 CDD:197581 48/305 (16%)
HNOBA <816..861 CDD:285003 7/44 (16%)
CYCc 840..1032 CDD:214485 23/145 (16%)
Guanylate_cyc 867..1053 CDD:278633 18/118 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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